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Erschienen in: memo - Magazine of European Medical Oncology 4/2019

14.11.2019 | short review

Management of nonmetastatic muscle invasive bladder cancer in the elderly

verfasst von: MD, FEBU Prof. Stephan Madersbacher

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 4/2019

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Summary

A substantial increase in the number of elderly patients with muscle invasive bladder cancer (MIBC) is expected in upcoming years due to demographic changes and the peak incidence of bladder cancer in the 8th decade of life. The management of these patients is mainly driven by chronological age, comorbidities, tumor characteristics (unifocality, multifocality, concomitant carcinoma in situ, depth of invasion) and the presence of tumor-related symptoms (hematuria, pain, bladder dysfunction). A potential algorithm for the treatment of elderly patients with MIBC is presented. Ideally these patients are managed by a multidisciplinary team that includes an in-depth geriatric assessment and in centers experienced with MIBC to avoid any delay for—potentially—curative treatment.
Literatur
2.
Zurück zum Zitat Schultzel M, Saltzstein SL, Downs TM, et al. Late age (85 years or older) peak incidence of bladder cancer. J Urol. 2008;179:1302–5. CrossRef Schultzel M, Saltzstein SL, Downs TM, et al. Late age (85 years or older) peak incidence of bladder cancer. J Urol. 2008;179:1302–5. CrossRef
4.
Zurück zum Zitat Berger I, Martini T, Wehrberger C, et al. Perioperative complications and 90-day mortality of radical cystectomy in the elderly (75+): a retrospective, multicentre study. Urol Int. 2014;93:296–302. CrossRef Berger I, Martini T, Wehrberger C, et al. Perioperative complications and 90-day mortality of radical cystectomy in the elderly (75+): a retrospective, multicentre study. Urol Int. 2014;93:296–302. CrossRef
5.
Zurück zum Zitat Koppie TM, Serio AM, Vickers AJ, et al. Age-adjusted Charlson comorbidity score is associated with treatment decisions and clinical outcomes for patients undergoing radical cystectomy for bladder cancer. Cancer. 2008;112:2384–92. CrossRef Koppie TM, Serio AM, Vickers AJ, et al. Age-adjusted Charlson comorbidity score is associated with treatment decisions and clinical outcomes for patients undergoing radical cystectomy for bladder cancer. Cancer. 2008;112:2384–92. CrossRef
6.
Zurück zum Zitat Froehner M, Brausi MA, Herr HW, et al. Complications following radical cystectomy for bladder cancer in the elderly. Eur Urol. 2009;56:443–54. CrossRef Froehner M, Brausi MA, Herr HW, et al. Complications following radical cystectomy for bladder cancer in the elderly. Eur Urol. 2009;56:443–54. CrossRef
7.
Zurück zum Zitat Fonteyne V, Ost P, Bellmunt J, et al. Curative treatment for muscle invasive bladder cancer in elderly patients: a systematic review. Eur Urol. 2018;73:40–50. CrossRef Fonteyne V, Ost P, Bellmunt J, et al. Curative treatment for muscle invasive bladder cancer in elderly patients: a systematic review. Eur Urol. 2018;73:40–50. CrossRef
8.
Zurück zum Zitat Comploj E, West J, Mian M, et al. Comparison of complications from radical cystectomy between old-old versus oldest-old patients. Urol Int. 2015;94:25–30. CrossRef Comploj E, West J, Mian M, et al. Comparison of complications from radical cystectomy between old-old versus oldest-old patients. Urol Int. 2015;94:25–30. CrossRef
9.
Zurück zum Zitat Liberman D, Lughezzani G, Sun M, et al. Perioperative mortality is significantly greater in septuagenarian and octogenarian patients treated with radical cystectomy for urothelial carcinoma of the bladder. Urology. 2011;77:660–6. CrossRef Liberman D, Lughezzani G, Sun M, et al. Perioperative mortality is significantly greater in septuagenarian and octogenarian patients treated with radical cystectomy for urothelial carcinoma of the bladder. Urology. 2011;77:660–6. CrossRef
10.
Zurück zum Zitat Berger I, Wehrberger C, Ponholzer A, et al. Impact of the use of bowel for urinary diversion on perioperative complications and 90-day mortality in patients aged 75 years or older. Urol Int. 2015;94:394–400. CrossRef Berger I, Wehrberger C, Ponholzer A, et al. Impact of the use of bowel for urinary diversion on perioperative complications and 90-day mortality in patients aged 75 years or older. Urol Int. 2015;94:394–400. CrossRef
11.
Zurück zum Zitat Gschwend JE, Hautmann RE, Volkmer BG, et al. Radical cystectomy and urinary diversion in elderly patients with increased comorbidity. Urologe A. 2004;43:930–4. PubMed Gschwend JE, Hautmann RE, Volkmer BG, et al. Radical cystectomy and urinary diversion in elderly patients with increased comorbidity. Urologe A. 2004;43:930–4. PubMed
12.
Zurück zum Zitat Herr HW. Transurethral resection of muscle-invasive bladder cancer:10-year outcome. J Clin Oncol. 2001;19:89–93. CrossRef Herr HW. Transurethral resection of muscle-invasive bladder cancer:10-year outcome. J Clin Oncol. 2001;19:89–93. CrossRef
13.
Zurück zum Zitat Solsona E, Iborra I, Collado A, et al. Feasibility of radical transurethral resection as monotherapy for selected patients with muscle invasive bladder cancer. J Urol. 2010;184:475–80. CrossRef Solsona E, Iborra I, Collado A, et al. Feasibility of radical transurethral resection as monotherapy for selected patients with muscle invasive bladder cancer. J Urol. 2010;184:475–80. CrossRef
14.
Zurück zum Zitat Goossens-Laan CA, Leliveld AM, Verhoeven RHA, et al. Effects of age and comorbidity on treatment and survival of patients with muscle-invasive bladder cancer. Int J Cancer. 2014;135:905–12. CrossRef Goossens-Laan CA, Leliveld AM, Verhoeven RHA, et al. Effects of age and comorbidity on treatment and survival of patients with muscle-invasive bladder cancer. Int J Cancer. 2014;135:905–12. CrossRef
15.
Zurück zum Zitat Martini T, Mayr R, Wehrbeger C, et al. Comparison of radical cystectomy with conservative treatment in geriatric (≥80) patients with muscle-invasive bladder cancer. Int Braz J Urol. 2013;39:622–30. CrossRef Martini T, Mayr R, Wehrbeger C, et al. Comparison of radical cystectomy with conservative treatment in geriatric (≥80) patients with muscle-invasive bladder cancer. Int Braz J Urol. 2013;39:622–30. CrossRef
16.
Zurück zum Zitat Williams SB, Kamat AM, Chamie K et al. Systematic review of comorbidity and competing-risks assessments for bladder cancer patients. Eur Urol Oncol. 2018;1:91–100. CrossRef Williams SB, Kamat AM, Chamie K et al. Systematic review of comorbidity and competing-risks assessments for bladder cancer patients. Eur Urol Oncol. 2018;1:91–100. CrossRef
17.
Zurück zum Zitat Martin C, West JM, Palermo S, et al. Elderly patients undergoing cystectomy, comparing preoperative American Society of Anaesthesiology and Eastern Cooperative Oncology Group score and operative approaches. Urologia. Epub Ahead Print]. 2019 Martin C, West JM, Palermo S, et al. Elderly patients undergoing cystectomy, comparing preoperative American Society of Anaesthesiology and Eastern Cooperative Oncology Group score and operative approaches. Urologia. Epub Ahead Print]. 2019
18.
Zurück zum Zitat Advanced Bladder Cancer (ABC) Meta-analysis Collaboration. Neoadjuvant chemotherapy in invasive bladder cancer: update of a systematic review and meta-analysis of individual patient data advanced bladder cancer (ABC) meta-analysis collaboration. Eur Urol. 2005 Aug;48(2):202–5; discussion 205–6. Epub 2005 Apr 21. Advanced Bladder Cancer (ABC) Meta-analysis Collaboration. Neoadjuvant chemotherapy in invasive bladder cancer: update of a systematic review and meta-analysis of individual patient data advanced bladder cancer (ABC) meta-analysis collaboration. Eur Urol. 2005 Aug;48(2):202–5; discussion 205–6. Epub 2005 Apr 21.
19.
Zurück zum Zitat Leone AR, Zargar-Shoshtari K, Diorio GJ, et al. Neoadjuvant Chemotherapy in Elderly Patients With Bladder Cancer: Oncologic Outcomes From a Single Institution Experience. Clin Genitourin Cancer. 2017;15:583–9. CrossRef Leone AR, Zargar-Shoshtari K, Diorio GJ, et al. Neoadjuvant Chemotherapy in Elderly Patients With Bladder Cancer: Oncologic Outcomes From a Single Institution Experience. Clin Genitourin Cancer. 2017;15:583–9. CrossRef
20.
Zurück zum Zitat Noon AP, Albertsen PC, Thomas F, et al. Competing mortality in patients diagnosed with bladder cancer: evidence of undertreatment in the elderly and female patients. Br J Cancer. 2013;108:1534–40. CrossRef Noon AP, Albertsen PC, Thomas F, et al. Competing mortality in patients diagnosed with bladder cancer: evidence of undertreatment in the elderly and female patients. Br J Cancer. 2013;108:1534–40. CrossRef
Metadaten
Titel
Management of nonmetastatic muscle invasive bladder cancer in the elderly
verfasst von
MD, FEBU Prof. Stephan Madersbacher
Publikationsdatum
14.11.2019
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 4/2019
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-019-00547-2

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