Human Parainfluenza Virus Type 3 Infections in Patients with Hematopoietic Stem Cell Transplants: the Mode of Nosocomial Infections and Prognosis

Satsuki Kakiuchi; Masanori Tsuji; Hidekazu Nishimura; Lixing Wang; Mutsuyo Takayama-Ito; Hitomi Kinoshita; Chang-Kweng Lim; Shuichi Taniguchi; Akira Oka; Masashi Mizuguchi; Masayuki Saijo

doi:10.7883/yoken.JJID.2017.424

Original Articles

Human Parainfluenza Virus Type 3 Infections in Patients with Hematopoietic Stem Cell Transplants: the Mode of Nosocomial Infections and Prognosis

Satsuki Kakiuchi, Masanori Tsuji, Hidekazu Nishimura, Lixing Wang, Mutsuyo Takayama-Ito, Hitomi Kinoshita, Chang-Kweng Lim, Shuichi Taniguchi, Akira Oka, Masashi Mizuguchi, Masayuki Saijo

Author information

Satsuki Kakiuchi
Department of Virology 1, National Institute of Infectious Diseases
Department of Developmental Medical Sciences, The University of Tokyo
Masanori Tsuji
Department of Hematology, Toranomon Hospital
Hidekazu Nishimura
Virus Research Center, Sendai Medical Center
Lixing Wang
Department of Virology 1, National Institute of Infectious Diseases
Mutsuyo Takayama-Ito
Department of Virology 1, National Institute of Infectious Diseases
Hitomi Kinoshita
Department of Virology 1, National Institute of Infectious Diseases
Chang-Kweng Lim
Department of Virology 1, National Institute of Infectious Diseases
Shuichi Taniguchi
Department of Hematology, Toranomon Hospital
Akira Oka
Department of Developmental Medical Sciences, The University of Tokyo
Masashi Mizuguchi
Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
Masayuki Saijo
Department of Virology 1, National Institute of Infectious Diseases
Department of Pediatrics, Graduate School of Medicine, The University of Tokyo

Keywords: hematopoietic stem cell transplantation, respiratory virus infection, immunocompromised patients, human parainfluenza virus type 3

JOURNAL FREE ACCESS

2018 Volume 71 Issue 2 Pages 109-115

DOI https://doi.org/10.7883/yoken.JJID.2017.424

Browse “Advance online publication” version

Details

Abstract

There have been a few prospective and comprehensive surveillance studies on the respiratory viral infections (RVIs) among patients undergoing hematopoietic stem cell transplantation (HSCT). A 2-year prospective cohort surveillance study of symptomatic and asymptomatic RVIs was performed in hospitalized HSCT patients. Oropharyngeal (OP) swab samples were serially collected each week from 1 week before and up to 100 days after HSCT and were tested for virus isolation with cell culture-based viral isolation (CC-based VI) and a multiplex PCR (MPCR). A total of 2,747 OP swab samples were collected from 250 HSCT patients (268 HSCT procedures). Among these patients, 79 had RVIs (CC-based VI, n = 63; MPCR, n = 17). The parainfluenza virus type 3 (PIV3) accounted for 71% (57/80) of the cases of RVIs. Some PIV3 infections were asymptomatic and involved a longer virus-shedding period. The PIV3 was often cultured from samples taken before the onset of a respiratory disease. The PIV3 infections were attributed to the transmission of nosocomial infections. PIV3 infections before engraftment will more likely result in the development of lower respiratory tract infections and worse outcomes. A real-time monitoring of respiratory viral infections in the HSCT ward among patients with or without respiratory symptoms is required for the prevention of nosocomial RVIs, especially of PIV3 infections.

Corresponding author

Register with J-STAGE for free!