Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015, 159(2):242-245 | DOI: 10.5507/bp.2014.036

The effect of Helicobacter pylori eradication on insulin resistance and HbA1c level in people with normal glucose levels: a prospective study

Zeynal Dogan, Murat Sarikaya, Bilal Ergul, Levent Filik
Ankara Education and Research Hospital, Gastroenterology, Turkey

Background and Aim. Helicobacter pylori (H. pylori) infection is reported to be associated with various extragastrointestinal conditions such as insulin resistance, diabetes mellitus and metabolic syndrome. These conditions are attributed to systemic inflammation, leptin or ghrelin changes due to H. pylori infection. Therefore, increasing trends in the management of H. pylori infection are ordered to maintain glycemic control. In this study, we evaluated the effect of H. pylori eradication on insulin resistance in patients with normal blood glucose concentrations.

Method: A total of 370 patients with successful eradication were included in the study. Patients with H. pylori were given triple eradication treatment. All patients with H. pylori infection were tested for fasting glucose, fasting insulin, glicated hemoglobin (HbA1c) at baseline and 6 months after eradication treatment. Also, insulin resistance was calculated using the homeostatic model assessment of insulin resistance (HOMA-IR). Body mass index was also determined as a metabolic syndrome criteria effecting insulin resistance.

Results: There were significant differences in fasting glucose, fasting insulin, HbA1c, and HOMA-IR values between before treatment and after treatment(P <0.04, <0.01, <0.01, <0.01). The favorable effect of eradication was more significant in patients with BMI≥25 mg/m2(P<0.05).

Conclusion: Eradication treatment has beneficial effects on insulin resistance in patients with normal glucose concentrations.

Keywords: Helicobacter pylori, insulin resistance, body mass index

Received: October 14, 2013; Accepted: June 10, 2014; Prepublished online: June 19, 2014; Published: June 28, 2015  Show citation

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Dogan, Z., Sarikaya, M., Ergul, B., & Filik, L. (2015). The effect of Helicobacter pylori eradication on insulin resistance and HbA1c level in people with normal glucose levels: a prospective study. Biomedical papers, 159(2), 242-245. doi: 10.5507/bp.2014.036
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    References

    1. Rothenbacker D, Brenner H. Burden of Helicobacter pylori and H. pylori related dideases in devoloped countries: recent developments and future implications. Microbes Infect 2003;5:693-703. Go to original source... Go to PubMed...
    2. Naito Y, Yoshikawa T. Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress. Free Radic Biol Med 2002;33:323-36. Go to original source... Go to PubMed...
    3. Ernst P. Review article: the role of inflammation in the pathogenesis of gastric cancer. Aliment Pharmacol Ther 1999;1:13-8. Go to original source... Go to PubMed...
    4. Kowalski M. Helicobacter pylori infection in coronary artery disease: influence of H. pylori eradication on coronary artery lümen after percutaneous transluminal coronary angioplasty. The detection of H. pylori spesific DNA in human coronary atherosclerotic plaque. J Physiol Pharmacol 2001;52:3-31. Go to original source...
    5. Gasbarrini A, Franceschi F, Tartaglione R, Landolfi R, Pola P, Gasbarrini G. Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori. Lancet 1998;352:878. Go to original source... Go to PubMed...
    6. Dufour C, Brisigotti M, Fabretti G, Luxardo P, Mori PG, Barabino A. Helicobacter pylori gastric infection and sideropenic refractory anemia. J Pediatr Gastroenterol Nutr 1993;17:225-7. Go to original source... Go to PubMed...
    7. Jeon CY, Haan MN, Cheng C, Clayton ER, Mayeda ER, Miller JW, Aiello AE. Helicobacter pylori infection is associated with an increased rate of diabetes. Diabetes Care 2012;35:520-5. Go to original source... Go to PubMed...
    8. Gunji T, Matsuhashi N, Sato H, Fujibayashi K, Okumura M, Sasabe N, Urabe A. Helicobacter pylori infection significantly increases insulin resistance in the asymptomatic Japanese population. Helicobacter 2009;14:144-50. Go to original source... Go to PubMed...
    9. Malfertheiner P, Megraud F, O'Morain CA, Atherton J, Axon AT, Bazzoli F, et al. Europen Helicobacter Study Group. Management of Helicobacter pylori infection- the Maastricht IV/Florence Consensus Report. Gut 2012;61:646-64. Go to original source... Go to PubMed...
    10. Polyzos SA, Kountouras J, Zavos C, Deretzi G. The association between Helicobacter pylori infection and insulin resistance: a systemic review. Helicobacter 2011;16:79-88. Go to original source... Go to PubMed...
    11. Gen R, Demir M, Ataseven H. Effect of Helicobacter pylori eradication on insulin resistance, serum lipids and low-grade inflammation. South Med J 2010;103:190-6. Go to original source... Go to PubMed...
    12. Park SH, Jeon WK, Kim SH, Kim HJ, Park DI, Cho YK, Sung IK, Sohn CI, Kim BI, Keum DK. Helicobacter Pylori eradication has no effect on metabolic and inflammatory parameters. J. Natl Med Assoc 2005;97:508-13. Go to PubMed...
    13. Rogge JD, Wagner DR, Carrico RJ, Glowinski EA, Mahoney SJ, Boguslaski RC, Genta RM. Evaluation of a new urease reagent strip for detection of Helicobacter pylori in gastric biopsy specimens. Am J Gastroenterol 1995;90:1965-8.
    14. Howden CW, Hunt RH. Guidelines for the management of Helicobacter pylori infection. Ad Hoc Committee on practice Parameters of the American College of gastroenterology. Am J Gastroenterol 1998;93:2330-8. Go to original source... Go to PubMed...
    15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia;28:412-9. Go to PubMed...
    16. Bardhan PK. Epidemiological features of Helicobacter pylori infection in developing countries. Clin Infect Dis 1997;25:973-8. Go to original source... Go to PubMed...
    17. Longo-Mbenza B, Nkondi Nsenga J, Vangu Ngoma D. Prevention of the metabolic syndrome insulin resistance and the atherosclerotic diseases in Africans infected by Helicobacter pylori infection and treated by antibiotics. Int J Cardiol 2007;18:229-38. Go to original source... Go to PubMed...
    18. Naja F, Nasreddine L, Hwalla N, Moghames P, Shoaib H, Fatfat M, Sibai A, Gali- Muhtasib H. association of H. pylori infection with insulin resistance and metabolic syndrome among Lebanese adults. Helicobacter 2012;17:444-51. Go to original source... Go to PubMed...
    19. Siddique NR, Garvey WT, Khaled MA. H. pylori-induced C-Reactive Protein in Obese African Americans. Artery Res 2009;3:39-42. Go to original source... Go to PubMed...
    20. Eshraghian A, Eshraghian H, Ranjbar Omrani G. Insulin resistance and metabolic syndrome: is Helicobacter pylori criminal? Minerva Gastroenterol Dietol 2011;57:379-85. Go to PubMed...
    21. Fernandez-Real JM, Ricart W. Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/phenotype to thriftiness. Diabetologia 1999;42:1367-74. Go to original source... Go to PubMed...
    22. Gulcelik NE, Kaya E, Demirbaº B, Culha C, Koc G, Ozkaya M, Cakal E, Serter R, Aral Y. Helicobacter pylori prevalance in diabetic patients and its relationship with dyspepsia and autonomic neuropathy. J Endocrinol Invest 2005;28:214-7. Go to original source... Go to PubMed...
    23. MC Gowan CC, Cover TL, Blaser MJ. Helicobacter pylori and gastric acid: biological and therapeutic implications. Gastroenterology 1996;110:926-38. Go to original source... Go to PubMed...
    24. Mendall MA, Patel P, Asante M, Ballam L, Morris J, Strachan DP, Camm AJ. Relation of serum cytokine cocentrations to cardiovascular risk factors and coronary heart disease. Heart 1997;78:273-7. Go to original source... Go to PubMed...
    25. Huhtinen HT, Grönroos JM, Haapamaki MM, Nevalainen TJ. Phospholipase A2 in gastric juice of Helicobacter pylori-positive and negative individuals. Clin Chem Lab Med 1999;37:61-4. Go to original source... Go to PubMed...
    26. Khaled MA, Mahalanabis D. Higher Serum Tumor Necrosis factor in H. pylori infected humans with higher body mass index. The FASEB J 2000;14:A248.
    27. Mizuno T, Ando T, Nobata K, Tsuzuki T, Maeda O, Watanabe O, Minami M, Ina K, Kusugami K, Peek RM, Goto H. Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization. World J Gastroenterol 2005;11:6305-11. Go to original source... Go to PubMed...
    28. Luzza F, Parrello T, Monteleone G, Sebkova L, Romano M, Zarrilli R, Imeneo M, Pallone F. Upregualtion of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa. J Immunol 2000;165:5332-7. Go to original source... Go to PubMed...
    29. Sebkova L, Pellicano A, Monteleone G, Grazioli B, Guarnieri G, Imeneo M, Pallone F, Luzza F. Extracellular signal-regulated protein kinase mediates interleukin 17(IL-17)-induced IL-8 secretion in Helicobacter pylori-infected human gastric epithelial cells. Infect Immun 2004;72:5019-26. Go to original source... Go to PubMed...
    30. Rahman MA, Cope MB, Sarker SA, Garvey WT, Chaudhury HS, Khaled MA. Helicobacter pylori infection and inflammation: Implication fort he pathophysiology of diabetes and coronary heart disease in asian indians. J Life Sci 2009;1:45-50. Go to original source... Go to PubMed...
    31. Hart AR, Kennedy H, Harvey I, Pancreatic cancer: a review of the evidence on causation. Clin Gastroenterol Hepatol 2008;6:275-82. Go to original source... Go to PubMed...
    32. Fosslien E. Mitochondral medicine-molecular pathology of defective oxidative phosphorilation. Ann Clin Lab Sci 2001;31:25-67.
    33. Hennige AM, Stefan N, Kapp K, Lehmann R, Weigert C, Beck A, Moeschel K, Mushack J, Schleicher E, Haring HU. Leptin down-regulates insulin action through phosphorilation of serine-318 in insulin receptor substrate 1. FASEB J 2006;20:1206-8. Go to original source... Go to PubMed...
    34. Pöykkö SM, Kellokoski E, Hörkkö S, Kauma H, Kesaniemi YA, Ukkola O. Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes 2003;52:46-53. Go to original source... Go to PubMed...
    35. Shiotani A, Miyanishi T, Uedo N, Lishi H. Helicobacter pylori infection is associated with reduced circulating ghrelin levels independent of body mass index. Helicobacter 2005;10:373-8. Go to original source... Go to PubMed...

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