Open Access

MRI features of growth hormone deficiency in children with short stature caused by pituitary lesions

  • Authors:
    • Chao Xu
    • Xinxian Zhang
    • Lina Dong
    • Bin Zhu
    • Tao Xin
  • View Affiliations

  • Published online on: April 24, 2017     https://doi.org/10.3892/etm.2017.4377
  • Pages: 3474-3478
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

We verified the advantages of using magnetic resonance imaging (MRI) for improving the diagnostic quality of growth hormone deficiency (GHD) in children with short stature caused by pituitary lesions. Clinical data obtained from 577 GHD patients with short stature caused by pituitary lesions were retrospectively analyzed. There were 354 cases (61.3%) with anterior pituitary dysplasia; 45 cases (7.8%) of pituitary stalk interruption syndrome (PSIS); 15 cases (2.6%) of pituitary hyperplasia due to primary hypothyroidism; 38 cases (6.6%) of Rathke cleft cyst; 68 cases (11.8%) of empty sella syndrome; 16 cases (2.8%) of pituitary invasion from Langerhans cell histiocytosis; 2 cases (0.3%) of sellar regional arachnoid cyst and 39 cases (6.8%) of craniopharyngioma. MRI results showed that the height of anterior pituitary in patients was less than normal. Location, size and signals of posterior pituitary and pituitary stalk were normal in anterior pituitary dysplasia. In all cases pituitary hyperplasia was caused by hypothyroidism. MRI results showed that anterior pituitary was enlarged, and we detected upward apophysis and obvious homogeneous enhancement. There were no pituitary stalk interruption and abnormal signal. We also observed that after hormone replacement therapy the size of pituitary gland was reduced. Anterior pituitary atrophy was observed in Rathke cleft cyst, empty sella syndrome, sellar regional arachnoid cyst and craniopharyngioma. The microstructure of hypophysis and sellar region was studied with MRI. We detected pituitary lesions, and the characteristics of various pituitary diseases of GHD in children with short stature. It was concluded that in children with GHD caused by pituitary lesions, MRI was an excellent method for early diagnosis. This method offers clinical practicability and we believe it can be used for differential diagnosis and to monitor the therapeutic effects.

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June-2017
Volume 13 Issue 6

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Copy and paste a formatted citation
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Spandidos Publications style
Xu C, Zhang X, Dong L, Zhu B and Xin T: MRI features of growth hormone deficiency in children with short stature caused by pituitary lesions. Exp Ther Med 13: 3474-3478, 2017
APA
Xu, C., Zhang, X., Dong, L., Zhu, B., & Xin, T. (2017). MRI features of growth hormone deficiency in children with short stature caused by pituitary lesions. Experimental and Therapeutic Medicine, 13, 3474-3478. https://doi.org/10.3892/etm.2017.4377
MLA
Xu, C., Zhang, X., Dong, L., Zhu, B., Xin, T."MRI features of growth hormone deficiency in children with short stature caused by pituitary lesions". Experimental and Therapeutic Medicine 13.6 (2017): 3474-3478.
Chicago
Xu, C., Zhang, X., Dong, L., Zhu, B., Xin, T."MRI features of growth hormone deficiency in children with short stature caused by pituitary lesions". Experimental and Therapeutic Medicine 13, no. 6 (2017): 3474-3478. https://doi.org/10.3892/etm.2017.4377