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Abstract

Background

Antibiotic resistance, either intrinsic or acquired, is a major obstacle for treating bacterial infections.

Aim

Our objective was to compare the country-specific species distribution of the four Gram-negative species , and species and the proportions of selected acquired resistance traits within these species.

Method

We used data reported for 2016 to the European Antimicrobial Resistance Surveillance Network (EARS-Net) by 30 countries in the European Union and European Economic Area.

Results

The country-specific species distribution varied considerably. While accounted for 31.9% to 81.0% (median: 69.0%) of all reported isolates, the two most common intrinsically resistant species and spp. combined (PSEACI) accounted for 5.5% to 39.2% of isolates (median: 10.1%). Similarly, large national differences were noted for the percentages of acquired non-susceptibility to third-generation cephalosporins, carbapenems and fluoroquinolones. There was a strong positive rank correlation between the country-specific percentages of PSEACI and the percentages of non-susceptibility to the above antibiotics in all four species (rho > 0.75 for 10 of the 11 pairs of variables tested).

Conclusion

Countries with the highest proportion of and spp. were also those where the rates of acquired non-susceptibility in all four studied species were highest. The differences are probably related to national differences in antibiotic consumption and infection prevention and control routines.

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2019-08-15
2024-04-16
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2019.24.33.1800538
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Strong correlation between the rates of intrinsically antibiotic-resistant species and the rates of acquired resistance in Gram-negative species causing bacteraemia, EU/EEA, 2016
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Vincent+Jarlier&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jarlier Vincent</a>, <a href="/search?value1=Liselotte+Diaz+H%C3%B6gberg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Diaz Högberg Liselotte</a>, <a href="/search?value1=Ole+E+Heuer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Heuer Ole E</a>, <a href="/search?value1=Jos%C3%A9+Campos&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Campos José</a>, <a href="/search?value1=Tim+Eckmanns&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Eckmanns Tim</a>, <a href="/search?value1=Christian+G+Giske&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Giske Christian G</a>, <a href="/search?value1=Hajo+Grundmann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Grundmann Hajo</a>, <a href="/search?value1=Alan+P+Johnson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Johnson Alan P</a>, <a href="/search?value1=Gunnar+Kahlmeter&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kahlmeter Gunnar</a>, <a href="/search?value1=Jos+Monen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Monen Jos</a>, <a href="/search?value1=Annalisa+Pantosti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pantosti Annalisa</a>, <a href="/search?value1=Gian+Maria+Rossolini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rossolini Gian Maria</a>, <a href="/search?value1=Nienke+van+de+Sande-Bruinsma&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van de Sande-Bruinsma Nienke</a>, <a href="/search?value1=Alkiviadis+Vatopoulos&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vatopoulos Alkiviadis</a>, <a href="/search?value1=Dorota+%C5%BBabicka&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Żabicka Dorota</a>, <a href="/search?value1=Helena+%C5%BDemli%C4%8Dkov%C3%A1&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Žemličková Helena</a>, <a href="/search?value1=Dominique+L+Monnet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Monnet Dominique L</a>, <a href="/search?value1=Gunnar+Skov+Simonsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Simonsen Gunnar Skov</a>, <a href="/search?value1=EARS-Net+participants&option1=author&noRedirect=true" class="nonDisambigAuthorLink">EARS-Net participants</a></span>. Strong correlation between the rates of intrinsically antibiotic-resistant species and the rates of acquired resistance in Gram-negative species causing bacteraemia, EU/EEA, 2016. <a href="/content/ecdc">Euro Surveill.</a> 2019;24(33):pii=1800538. <a href="https://doi.org/10.2807/1560-7917.ES.2019.24.33.1800538" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2019.24.33.1800538</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 03 Oct 2018;&nbsp;&nbsp; <span class="generated">Accepted</span>: 01 Apr 2019 </span> </p>
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