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Effects of α1-Adrenoceptor Antagonists on Male Sexual Function

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Abstract

α1-Adrenoceptor antagonists such as alfuzosin, doxazosin, tamsulosin and terazosin are first-line agents for the treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH), but are only second-line agents (doxazosin and terazosin only) for the treatment of arterial hypertension. Sexual function is complex and includes multiple domains such as sexual desire (libido), erectile function and ejaculatory function. Erectile and ejaculatory functions are frequently reduced in patients with BPH and can impact on their quality of life. Therefore, the treatment of BPH should aim to maintain or even restore sexual function.

α1-Adrenoceptor antagonists lack major effects on sexual desire in placebo-controlled studies. Reports on erectile function are inconsistent, with both beneficial and adverse effects being reported, but impotence can occur in some patients without clear differences between drugs. Ejaculatory dysfunction during treatment may represent (relative) anejaculation. It occurs more frequently with tamsulosin than with other drugs of this class, but the differences are not big enough to be consistently detectable in directly comparative studies. We propose that such differences between drugs should be weighed against differences in cardiovascular tolerability when choosing the optimal treatment for each patient.

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Acknowledgements

Within the last 5 years, the authors have received research support, consultancy and/or speakers’ honoraria from the following companies marketing α-blockers: Astellas, Boehringer Ingelheim, Pfizer and Sanofi-Aventis.

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  1. Department of Urology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Marleen M. van Dijk & Jean J. M. C. H. de la Rosette

  2. Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Martin C. Michel

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  1. Marleen M. van Dijk
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van Dijk, M.M., de la Rosette, J.J.M.C.H. & Michel, M.C. Effects of α1-Adrenoceptor Antagonists on Male Sexual Function. Drugs 66, 287–301 (2006). https://doi.org/10.2165/00003495-200666030-00002

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