Chest
Clinical InvestigationsLung Cancer ScreeningLung Cancer Screening Using Low-Dose Spiral CT: Results of Baseline and 1-Year Follow-up Studies
Section snippets
Subjects
All participants gave informed consent at presentation for CT screening, and filled out questionnaires about respiratory symptoms and smoking history. From April 1998 to August 2000, A total of 13,524 CT screening procedures were performed, consisting of 7,956 procedures as baseline screening and 5,568 procedures as repeat screening 1 year later. The characteristics of the participants are summarized in Table 1. The majority of participants were men, with ages ranging from 50 to 59 years. The
Prevalence of SPNs at Baseline Screening
During the baseline screening, a total of 2,865 noncalcified SPNs (in 2,099 patients) were detected in 7,956 patients (26.3%). The prevalence of SPNs by age and sex is shown in Figure 2. The prevalence of SPNs seemed to be high among the elderly participants. There was no significant difference by smoking history at any age.
Results of the Baseline Screening
Of the 7,956 participants, 541 patients (6.8%) were encouraged to undergo a detailed CT scan (Table 2). In total, 64 patients underwent additional examinations consisting of
Discussion
Henschke et al8 reported that low-dose CT identified 233 individuals as having from one to six noncalcified nodules, among 1,000 participants. Our data were similar to those of their report, and we found these nodules in 26.3% of participants. Although the prevalence of CT-detected SPNs has not yet been reported in Japan, it seems to be high in view of the age of participants in this study (approximately 70% were 50 to 59 years old). The high prevalence of granulomatous disease, especially old
ACKNOWLEDGMENT
We thank Katsuyuki Endo, MD; Noboru Yanai, MD; Masataka Irokawa, MD; and Shimao Fukai, MD for thorough examination and treatment of screened cases, and also all related staff who took part in this screening program.
References (14)
- et al.
Early Lung Cancer Action Project: overall design and findings from baseline screening
Lancet
(1999) - et al.
Early lung cancer detection: results of the initial (prevalence) radiologic and cytologic screening in the Memorial-Sloan Kettering study
Am Rev Respir Dis
(1984) - et al.
Early lung cancer detection; results of the initial (prevalence) radiologic and cytologic screening in the Mayo clinic study
Am Rev Respir Dis
(1984) - et al.
Lung cancer screening: the Mayo program
J Occup Med
(1986) Survival and mortality from lung cancer in a screened population: the Johns Hopkins study
Chest
(1986)- et al.
Peripheral lung cancer: screening and detection with low-dose spiral CT versus radiography
Radiology
(1996)
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2022, Respiratory InvestigationCitation Excerpt :Lung cancer was detected in never smokers as well as current or former smokers. Although no conclusions have been reached regarding the effectiveness of CT screening in never smokers, lung cancer detection rates are reportedly high in female never smokers in Japan [15,16]. The effectiveness of CT screening in never smokers was also reported by some cohort studies [10,11].
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