Chest
Original ResearchSarcoidosisResults of 188 Whole-Body Fluorodeoxyglucose Positron Emission Tomography Scans in 137 Patients With Sarcoidosis
Section snippets
Materials and Methods
All patients attended the sarcoidosis service at Mount Sinai Medical Center (New York, NY). A total of 88 patients underwent whole-body scans as part of a study of perfusion (82Rb) and metabolic FDG PET scan imaging for the diagnosis and treatment of cardiac sarcoidosis. In addition, 49 patients underwent only whole-body FDG PET scans for one of the following indications: (1) seeking a diagnostic biopsy site not identified by standard techniques; and (2) identifying reversible granulomatous
Results
There were 72 men and 65 women in the study; 68 were white, 63 were African American, and 6 were other. The mean age was 50.4 years (age range, 19 to 81 years).
A total of 139 of the 188 FDG PET scans revealed hypermetabolism in the 137 patients. Table 1shows the results of the 139 extracardiac positive FDG PET scan findings in 137 patients. Forty-nine scans exhibited no extracardiac uptake of FDG. Mediastinal and extrathoracic lymph nodes and lungs were the most common sites of extracardiac PET
Discussion
In the vast majority of patients with sarcoidosis, the diagnosis is available by biopsy of a wide variety of organs. Twenty-six diagnostic biopsy sites were reported in A Case Controlled Etiologic Study of Sarcoidosis.9 Rarely, the clinical presentation suggests the diagnosis of sarcoidosis, but no readily available biopsy site is identified or only a single organ system is involved (eg, the patient who presents with anterior uveitis, normal chest radiograph findings, and no other imaging or
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All authors listed have no actual or potential conflicts of interest.