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Predictive Factors for Hypertrophy of the Future Remnant Liver After Selective Portal Vein Embolization

  • Hepatobiliary Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

To analyze predictive factors of hypertrophy of the nonembolized future remnant liver (FRL) after transhepatic preoperative portal vein embolization (PVE) of the liver to be resected.

Materials and Methods

Age, gender, indocyanin green clearance test, chemotherapy before PVE, type of chemotherapy, operators, extent of PVE, radiofrequency ablation (RFA) associated with PVE, time delay between PVE and surgery, and platelet count were retrospectively evaluated as predictive factors for hypertrophy of FRL in 107 patients with malignant disease in noncirrhotic liver. PVE targeted the right liver lobe [n = 70] or the right liver lobe and segment IV [n = 37] when FRL/total liver volume ratio was below 25% in healthy liver or 40% in altered liver.

Results

After PVE, FRL volume significantly increased by 69%, from 344 ± 156 cm3 to 543 ± 192 cm3 (P < .0001). The degree of hypertrophy was negatively correlated with FRL volume (correlation coefficient = −0.55, P < .0001) and FRL/TFL ratio (correlation coefficient = −0.52, P < .0001) before PVE. Patients, who have undergone chemotherapy with platin agents prior to PVE, demonstrated lower hypertrophy (P = .048).

Conclusion

Hypertrophy after PVE is inversely correlated to initial FRL volume. Hypertrophy of the liver might be influenced by the systemic chemotherapeutic received before PVE.

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Acknowledgment

The authors thank Joey Marie Robinson for editing the manuscript.

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Authors and Affiliations

  1. Department of Interventional Radiology, Institut Gustave Roussy, Villejuif, France

    Thierry de Baere MD, Christophe Teriitehau MD, Frederic Deschamps MD, Laurence Catherine MD, Pramod Rao MD, Antoine Hakime MD & Lukas Hechelhammer MD

  2. Department of Biostatistics, Institut Gustave Roussy, Villejuif, France

    Anne Auperin MD

  3. Department of Surgical Oncology, Institut Gustave Roussy, Villejuif, France

    Diane Goere MD & Dominique Elias MD

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  1. Thierry de Baere MD
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  2. Christophe Teriitehau MD
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Correspondence to Thierry de Baere MD.

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de Baere, T., Teriitehau, C., Deschamps, F. et al. Predictive Factors for Hypertrophy of the Future Remnant Liver After Selective Portal Vein Embolization. Ann Surg Oncol 17, 2081–2089 (2010). https://doi.org/10.1245/s10434-010-0979-2

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  • DOI: https://doi.org/10.1245/s10434-010-0979-2

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