Journal of Lipid Research
Volume 58, Issue 3, March 2017, Pages 504-511
Research ArticlesHepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice
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open access
cholesterol
cholesterol 7-alpha hydroxylase
liver
gene expression
endoplasmic reticulum
unfolded protein response
serum 7α-hydroxy-4-cholesten-3-one
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This work was supported by National Institute of Diabetes and Digestive and Kidney Diseases Grant R01 DK093807, the George Lockerbie Liver Cancer Foundation, and the Max Goldenberg Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
- C4
7α-hydroxy-4-cholesten-3-one
- CYP7A1
cholesterol 7α-hydroxylase
- ER
endoplasmic reticulum
- GO
Gene Ontology
- IRE1α
inositol-requiring enzyme 1α KEGG, Kyoto Encyclopedia of Genes and Genomes
- LS-Xbp1−/−
liver-specific X-box binding protein 1 knockout
- LXR
liver X receptor
- TC
taurocholic acid
- TMCA
tauromuricholic acid
- UPR
unfolded protein response
- XBP1
X-box binding protein 1
Abbreviations:
© 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.