Thromb Haemost 2013; 109(06): 1170-1179
DOI: 10.1160/TH12-11-0874
New Technologies, Diagnostic Tools and Drugs
Schattauer GmbH

Development and definition of a simplified scanning procedure and scoring method for Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US)

Carlo Martinoli
1   Radiologia – DISSAL, Università di Genova, Italy
,
Ornella Della Casa Alberighi
3   Direzione Scientifica – Unità di Farmacologia Clinica e Sperimentazioni Cliniche, IRCCS Istituto „G. Gaslini”, Genova, Italy
,
Giovanni Di Minno
5   Dipartimento di Medicina Clinica e Sperimentale. Università di Napoli, Italy
,
Ermelinda Graziano
6   Dipartimento di Medicina – Scienze dell’Invecchiamento. Università di Chieti-Pescara, Italy
,
Angelo Claudio Molinari
4   Unità di Trombosi ed Emostasi – IRCCS Istituto „G. Gaslini”, Genova, Italy
,
Gianluigi Pasta
7   Dipartimento di Ortopedia, Policlinico Universitario di Milano, Italy
,
Giuseppe Russo
1   Radiologia – DISSAL, Università di Genova, Italy
,
Elena Santagostino
8   Centro di Emofila e Trombosi „AB Bonomi”, Policlinico Universitario di Milano, Italy
,
Annarita Tagliaferri
9   Dipartimento di Medicina Interna – AOU Parma, Italy
,
Alberto Tagliafico
2   Istituto di Anatomia Umana – DIMES, Università di Genova, Italy
,
Massimo Morfini
10   Centro Emofilia – AOU “Careggi” Firenze, Italy
› Author Affiliations
Further Information

Publication History

Received: 29 November 2012

Accepted after minor revision: 28 February 2013

Publication Date:
22 November 2017 (online)

Summary

The aim of this study was to develop a simplified ultrasound scanning procedure and scoring method, named Haemophilia Early Arthropathy Detection with UltraSound [HEAD-US], to evaluate joints of patients with haemophilic arthropathy. After an initial consensus-based process involving a multidisciplinary panel of experts, three comprehensive and evidence-based US scanning procedures to image the elbow, knee and ankle were established with the aim to increase sensitivity in detection of early signs of joint involvement while keeping the technique easy and quick to perform. Each procedure included systematic evaluation of synovial recesses and selection of a single osteochondral surface for damage analysis. Based on expert consensus, a simplified scoring system based on an additive scale was created to define the joint status and, in perspective, to offer a tool to evaluate disease progression and monitor the result of treatment in follow-up studies.

 
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