Review Article
A diagnostic approach to mild bleeding disorders

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Summary

Mild inherited bleeding disorders are relatively common in the general population. Despite recent advances in diagnostic approaches, mild inherited bleeding disorders still pose a significant diagnostic challenge. Hemorrhagic diathesis can be caused by disorders in primary hemostasis (von Willebrand disease, inherited platelet function disorders), secondary hemostasis (hemophilia A and B, other (rare) coagulant factor deficiencies) and fibrinolysis, and in connective tissue or vascular formation. This review summarizes the currently available diagnostic methods for mild bleeding disorders and their pitfalls, from structured patient history to highly specialized laboratory diagnosis. A comprehensive framework for a diagnostic approach to mild inherited bleeding disorders is proposed.

Keywords

bleeding disorder
bleeding score
blood coagulation disorders
diagnosis
DNA sequencing
hemostasis

Cited by (0)

Manuscript handled by: D. DiMichele

Final decision: F. R. Rosendaal, 8 May 2016