Clinical InvestigationBODE Index and GOLD Staging as Predictors of 1-Year Exacerbation Risk in Chronic Obstructive Pulmonary Disease
Section snippets
Patients
One hundred twenty consecutive patients with COPD with a wide range of disease severity were recruited from the outpatient clinic of a single institution between July 2004 and August 2006. Major inclusion criteria were clinical diagnosis of COPD according to the criteria set out in GOLD 2003 and the Brazilian Thoracic Society (BTS)17., 18.: age ≥ 40 years, smoking history ≥ 10 pack-years, and a postbronchodilator FEV1/forced vital capacity ratio < 70%. Disease severity was categorized according to
RESULTS
Baseline characteristics of COPD according to the presence or absence of exacerbation during follow-up are presented in Table 1. Patients with COPD (71% men) with a mean age of 65 ± 9.5 years were evaluated. A total of 20% were in GOLD stage I, 38% in GOLD stage II, 17% in GOLD stage III, and 25% in GOLD stage IV. A total of 62.5% were in BODE class 1, 22.5% in BODE class 2, and 15% in BODE classes 3 and 4. Sixty patients (50%) presented with at least 1 exacerbation during follow-up; median
DISCUSSION
This prospective study compared the GOLD staging system and the BODE index as predictors of exacerbation in a cohort of stable ambulatory patients with COPD with a wide range of airway obstruction during the 1-year period. Results of the logistic regression and ROC analysis showed that the influences of the BODE index and the GOLD stage on exacerbation risk during the first year of follow-up was similar. In an adjusted analysis, we identified that more advanced age and lower SpO2 were
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Cited by (0)
This study was supported by a Research Grant from FAPESP (Fundação de Amparo á Pesquisa do Estado de São Paulo, São Paulo, Brazil) 04/00517-4.