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The metabolism of high intakes of tryptophan, nicotinamide and nicotinic acid in the rat

Published online by Cambridge University Press:  09 March 2007

Gwyn M. McCreanor  and
David A. Bender
Gwyn M. McCreanor
Affiliation:
Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London WIP 7PN
David A. Bender
Affiliation:
Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, London WIP 7PN
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Abstract

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1. The metabolic fate of high dietary intakes of nicotinamide, nicotinic acid and tryptophan, and of acute doses of nicotinamide and nicotinic acid, has been studied in the rat. A new high-pressure liquid chromatography method for measurement of the principal urinary metabolites of niacin is described.

2. Administration to rats of a single oral dose of nicotinamide or nicotinic acid (up to 100 mg/kg body-weight), or maintenance for 3 weeks on diets providing 150 mg nicotinamide or nicotinic acid/kg diet, resulted in only a small increase in the liver content of nicotinamide nucleotide coenzymes (NAD and NADP). The quantitative metabolism of nicotinamide and nicotinic acid differed, suggesting that intestinal bacterial deamidation is not the major fate of nicotinamide.

3. A high dietary intake of tryptophan (5.9 g/kg diet) led to a considerable increase in liver NAD(P) and also in urinary excretion of niacin metabolites. The results suggest that, as indicated by enzyme kinetic studies (Bender et al. 1982), the utilization of nicotinamide and nicotinic acid for nucleotide synthesis is limited, while there is little or no limitation of NAD(P) synthesis from the tryptophan metabolite quinolinic acid.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 56 , Issue 3 , November 1986 , pp. 577 - 586
Copyright
Copyright © The Nutrition Society 1986

References

REFERENCES

Baggenstoss, A. H., Christenson, N. A., Berge, K. G., Baldus, W. P., Spiekerman, R. E. & Ellefson, R. D. (1967). Mayo Clinic Proceedings 42, 385–399.Google Scholar
Ban, T. A. (1974). International Pharmacopsychiatry 9, 172–187.CrossRefGoogle Scholar
Baron, D. N., Dent, C. E., Harris, H., Hart, E. W. & Jepson, J. B. (1956). Lancet ii, 421–428.CrossRefGoogle Scholar
Bartlett, P. C., Morris, J. G. & Spengler, J. (1982). US Public Health Reports 97, 258–260.Google Scholar
Bender, D. A. (1980). Biochemical Pharmacology 29, 2099–2104.CrossRefGoogle Scholar
Bender, D. A., Clifford, E., McCreanor, G. M. & Smith, A. D. (1987). Proceedings of the Nutrition Society (In the Press).Google Scholar
Bender, D. A., Magboul, B. I. & Wynick, D. (1982). British Journal of Nutrition 48, 119–127.CrossRefGoogle Scholar
Berger, N. A., Weber, G. & Kaicha, A. (1978). Biochimica et Biophysica Acta 519, 87–104.CrossRefGoogle Scholar
Biehl, J. P. & Vilter, R. W. (1954). Proceedings of the Society for Experimental Biology and Medicine 85, 389–395.CrossRefGoogle Scholar
Blom, W., van den Berg, G. B., Huijmans, J. G. M. & Sanders-Woudstra, J. A. R. (1985). Journal of Inherited Metabolic Diseases 8, Suppl. 2, 107–108.CrossRefGoogle Scholar
Carpenter, K. J. & Kodicek, E. (1950). Biochemical Journal 46, 421–426.CrossRefGoogle Scholar
Carpenter, K. J. & Lewin, W. J. (1985). Journal of Nutrition 115, 543–552.CrossRefGoogle Scholar
Carter, E. G., Hurrell, R. F. & Carpenter, K. J. (1977). Proceedings of the Nutrition Society 36, 107A.Google Scholar
Castiello, R. J. & Lynch, P. J. (1972). Archives of Dermatology 105, 574–577.CrossRefGoogle Scholar
Corr, P. B. & May, D. G. (1975). Journal of Pharmacology and Experimental Therapeutics 192, 195–200.Google Scholar
Gadd, R. E. A. & Johnson, W. J. (1974). International Journal of Biochemistry 5, 397–407.CrossRefGoogle Scholar
Hankes, L. V., Henderson, L. M., Brickson, W. L. & Elvehjem, C. A. (1948). Journal of Biological Chemistry 174, 873–881.CrossRefGoogle Scholar
Harrison, R. J. & Feiwel, M. (1956). British Medical Journal ii, 852–854.CrossRefGoogle Scholar
Hoffer, A. (1971). Canadian Psychiatric Association Journal 16, 499–504.CrossRefGoogle Scholar
Hoffer, A., Osmond, H., Callbeck, M. J. & Kahan, I. (1957). Journal of Clinical and Experimental Psychoparhology 18, 131–158.Google Scholar
Holman, W. I. M. & Wiegand, C. (1948). Biochemical Journal 43, 423–426.CrossRefGoogle Scholar
Johnson, W. J. & Gadd, R. E. A. (1974). International Journal of Biochemistry 5, 633–641.CrossRefGoogle Scholar
Kang-Lee, Y. A. E., McKee, R. W., Wright, S. M., Swendseid, M. E., Jenden, D. J. & Jope, R. S. (1983). Journal of Nutrition 113, 215–221.CrossRefGoogle Scholar
Kaplan, N. O., Colowick, S. P. & Barnes, C. C. (1951). Journal of Biological Chemistry 191, 461–472.CrossRefGoogle Scholar
Krehl, W. A., Sarma, P. S., Teply, L. J. & Elvehjem, C. A. (1946). Journal of Nutrition 31, 85–106.CrossRefGoogle Scholar
Lehman, J. (1972). Acta Physiologica Scandinavica Suppl.237.Google Scholar
Levi, V., Jacobson, E. & Jacobson, M. (1978). FEBS Letters 88, 144–146.CrossRefGoogle Scholar
Lowry, O. H., Passoneau, J. V. & Rock, M. K. (1961). Journal of Biological Chemistry 236, 2756–2759.CrossRefGoogle Scholar
McCreanor, G. M. & Bender, D. A. (1983). Biochimica et Biophysica Acta 759, 222–228.CrossRefGoogle Scholar
Magboul, B. I. & Bender, D. A. (1983). British Journal of Nutrition 49, 321–324.CrossRefGoogle Scholar
National Research Council (1962). Nutrient Requirements of Laboratory Animals, Washington DC: US Government Printing Office.Google Scholar
Osmond, H. & Hoffer, A. (1962). Lancet i, 316–320.CrossRefGoogle Scholar
Parsons, W. B. (1961 a). Archives of Internal Medicine 107, 639–652.CrossRefGoogle Scholar
Parsons, W. B. (1961 b). Archives of Internal Medicine 107, 653–667.CrossRefGoogle Scholar
Pollin, W., Cardon, P. V. & Kety, S. S. (1961). Science 133, 104–105.CrossRefGoogle Scholar
Purnell, M. R. & Whish, W. J. D. (1980). Biochemical Journal 185, 775–777.CrossRefGoogle Scholar
Salih, M. A. M., Bender, D. A. & McCreanor, G. M. (1985). Pediatrics 76, 787–793.CrossRefGoogle Scholar
Swain, C. P., Tavill, A. S. & Neale, G. (1976). Gastroenterology 71, 484–487.CrossRefGoogle Scholar
Winter, S. L. & Boyer, J. L. (1973). New England Journal of Medicine 289, 1180–1182.CrossRefGoogle Scholar