Journal of Biological Chemistry
Volume 295, Issue 15, 10 April 2020, Pages 4773-4779
Editors' PicksThe antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus
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plus-stranded RNA virus
viral polymerase
drug development
enzyme inhibitor
nucleoside/nucleotide analog
coronavirus
positive-sense RNA virus
Ebola virus (EBOV)
Middle East respiratory syndrome coronavirus (MERS–CoV)
SARS–CoV-2
remdesivir
antiviral drug
RNA chain termination
RNA-dependent RNA polymerase (RdRp)
viral replicase
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This study was supported by Canadian Institutes of Health Research Grant 159507 (to M. G.) and a grant from the Alberta Ministry of Economic Development, Trade and Tourism by the Major Innovation Fund Program for the AMR–One Health Consortium (to M. G.). M. G. has previously received funding from Gilead Sciences in support for the study of EBOV RdRp inhibition by RDV.
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These authors contributed equally to this work.
© 2020 Gordon et al.