Journal of Biological Chemistry
Volume 294, Issue 14, 5 April 2019, Pages 5430-5437
Accelerated CommunicationsGranulocyte–macrophage colony-stimulating factor inactivation in CAR T-cells prevents monocyte-dependent release of key cytokine release syndrome mediators
Under a Creative Commons license
open access
immunotherapy
cancer therapy
gene knockout
gene transfer
T-cell
CAR T-cell therapy
cytokine release syndrome (CRS)
granulocyte–macrophage colony-stimulating factor (GMCSF)
interleukin signaling
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The authors declare that they have no conflicts of interest with the contents of this article.
This article contains Figs. S1–S6.
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The abbreviations used are:
- CAR T-cell
chimeric antigen receptor T-cell
- CRS
cytokine release syndrome
- GMCSF
granulocyte macrophage–colony-stimulating factor
- ANOVA
analysis of variance
- IFNγ
interferon γ
- TNFα
tumor necrosis factor α
- IL
interleukin
- Ab
antibody
- PBMC
peripheral blood mononuclear cell
- ALL
acute lymphoblastic leukemia
- TCR
T-cell receptor
- AAV6
adeno-associated virus type 6
- vg
viral genome.
© 2019 Sachdeva et al.