Clinical Investigations: ElectrophysiologyAssociation of the human minK gene 38G allele with atrial fibrillation: Evidence of possible genetic control on the pathogenesis of atrial fibrillation☆,☆☆,★
Section snippets
Study population
Case patients were 108 consecutive patients who were admitted to our adult cardiology ward and had a history of atrial fibrillation. Patients with hyperthyroidism were excluded. For every case patient, a matched control subject without a history of atrial fibrillation was selected from the same ward. The case patients and control subjects were matched regarding sex, age, presence of left ventricular dysfunction (ejection fraction, <55%), and presence of significant valvular heart disease (at
Characteristics of study patients
The characteristics of the study patients are shown in Table I. No significant differences were seen between the case patients and control subjects with regard to demographic data, body weight, body height, body mass index, and common cardiovascular risk factors, such as hypertension, diabetes, and smoking. Of the control subjects, 17 had aortic valve disease, 22 had mitral valve disease, and 8 had double valve disease, and of the case patients, 13 had aortic valve disease, 25 had mitral valve
Discussion
We reported the association between the minK 38G allele and the risk of atrial fibrillation. Our findings suggest possible genetic control on the pathogenesis of atrial fibrillation.
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Cited by (0)
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Supported by the National Taiwan University Hospital Research grant number 90N023.
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Reprint requests: Jiunn-Lee Lin, MD, Department of Internal Medicine, National Taiwan University Hospital, No 7, Chung-Shan South Rd, Taipei, Taiwan.
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E-mail: [email protected]