Clinical Investigations: Acute Ischemic Heart DiseasePrevalence and clinical correlates of peripheral arterial disease in the Framingham Offspring Study☆,☆☆
Section snippets
Methods
Children of the original cohort of the Framingham Heart Study and their spouses were recruited in 1971 to form the Framingham Offspring Study cohort. The 5124 Offspring participants have been examined approximately every 4 years since the study's inception. All participants aged ≥40 years who attended the 6th Offspring cycle examination from 1995 to 1998 were eligible for inclusion in this study. Informed consent was obtained from study participants at the time of their examination. The
Results
Among the 1554 males and 1759 females included in this sample, 3.6% had an abnormal ABI of <0.9, 7.1% had a borderline ABI of 0.9 to 1.0, and 89.3% had a normal ABI of >1.0. The prevalence of current intermittent claudication was 1.9% in males and 0.8% in females (Table I).Manifestation Males (n = 1554) Females (n = 1759) Ankle-brachial index < 0.9 (%) 3.9 3.3 Current intermittent claudication (%) 1.9 0.8 Lower extremity bruit (%) 2.4 2.3
Discussion
In our unselected sample of middle-aged Framingham males and females, the prevalence of PAD, as determined by ABI, was 3% to 4%. The Atherosclerosis Risk In Communities (ARIC) study and 2 reports of middle-aged population samples derived from countries outside the United States found the prevalence of PAD to be similar to that observed in our sample.19, 20, 21 The prevalence of PAD was lower in our sample than some other population-based reports; in part a result of differences in the age
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Reprint requests: Joanne M. Murabito, MD, MSc, The Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702-5827.
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E-mail: [email protected]