Endoscopy 2005; 37(11): 1073-1078
DOI: 10.1055/s-2005-870416
DDW Highlights
© Georg Thieme Verlag KG Stuttgart · New York

Capsule Endoscopy

M.  Pennazio1
  • 1Dept. of Gastroenterology and Clinical Nutrition, S. Giovanni A.S. Hospital, Turin, Italy
Further Information

Publication History

Publication Date:
10 November 2005 (online)

Introduction

This year’s Digestive Disease Week saw the presentation of more than 80 studies focusing on capsule endoscopy (CE); this review discusses in detail the 20 most significant of these. Alongside various reports concerning technical aspects of the procedure, possible new applications have been studied, including in celiac disease. Obscure bleeding is now a consolidated indication to CE; however, prospective data on the impact of CE on clinical outcomes are still scarce. Opinions diverge on the effective role of CE in Crohn’s disease, and further research is needed to define this role. Research is also underway to develop capsules with propulsive and therapeutic capabilities. The strong interest in small-bowel endoscopy is also shown by the numerous studies concerning double-balloon enteroscopy, a complementary procedure to CE (Figure [1]).

Figure 1 The numbers of abstracts devoted to capsule endoscopy and double-balloon enteroscopy at Digestive Disease Week 2005.

References

  • 1 Fernández-Urién Sainz I, Espinet E, Pérez N. et al . Capsule endoscopy (CE) interpretation: the role of physician extenders [abstract].  Gastrointest Endosc. 2005;  61 (5) AB164
  • 2 Niv Y, Niv G. Capsule endoscopy examination: preliminary review by a nurse [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A82
  • 3 De Leusse A, Vahedi K, Edery J. et al . Efficiency of capsule endoscopy and push enteroscopy as the first line exploration of obscure gastrointestinal bleeding: a prospective randomized pragmatic study [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A81
  • 4 Tartaro P, Gregor J, Ponich T. A cost-effectiveness model to determine the sequence of capsule endoscopy and/or push enteroscopy in the investigation of obscure gastrointestinal bleeding [abstract].  Gastrointest Endosc. 2005;  61 (5) AB156
  • 5 Haghighi D, Zuccaio G, Vargo J. et al . Comparison of capsule endoscopy (CE) findings of healthy subjects (HS) to an obscure gastrointestinal bleeding (OGIB) patient population [abstract].  Gastrointest Endosc. 2005;  61 (5) AB104
  • 6 De la Mora J G, Rajan E, Knipschield M A. et al . Diagnostic yield of intraoperative enteroscopy when guided by capsule enteroscopy [abstract].  Gastrointest Endosc. 2005;  61 (5) AB105
  • 7 Hadithi M, Heine D G, Jacobs M A. et al . A prospective study comparing video capsule endoscopy followed by double balloon enteroscopy for suspected small bowel disease [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A82
  • 8 Nakamura M, Niwa Y, Ohmiya N. et al . A preliminary comparison of capsule endoscopy and double-balloon enteroscopy in patients with suspected small bowel bleeding [abstract].  Gastrointest Endosc. 2005;  61 (5) AB176
  • 9 Esrailian E, Targownik L E, Spiegel B M. et al . Is wireless capsule endoscopy (WCE) appropriate for the diagnosis and management of Crohn’s disease (CD)? A survey of North American inflammatory bowel disease (IBD) experts [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A73
  • 10 Solem C A, Loftus E V Jr, Fletcher J G. et al . Small bowel (SB) imaging in Crohn’s disease (CD): a prospective, blinded, 4-way comparison trial [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A74
  • 11 Bourreille A, Jarry M, d’Halluin P. et al . Small bowel recurrence following ileocolectomy for Crohn’s disease: a prospective evaluation using the wireless capsule enteroscopy (WCE) [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A305
  • 12 de Franchis R, Riccioni M E, Cave D. et al . Video capsule endoscopy for the diagnosis of celiac disease: preliminary results from a multicenter international study [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A82
  • 13 Dubcenco E, Jeejeebhoy K N, Petroniene R. et al . Capsule endoscopy (CE) in evaluation of patients with celiac disease (CD) [abstract].  Gastrointest Endosc. 2005;  61 (5) AB163
  • 14 Krauss N G, Cellier C, Collin P. et al . Evaluation of capsule endoscopy in celiac disease patients with ongoing symptoms on a gluten-free diet: a prospective, blinded European multicenter trial [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A81
  • 15 Neumann S, Schoppmeyer K, Wiedmann M. et al . Wireless capsule endoscopy in comparison to esophagogastroduodenoscopy for the diagnosis of acute intestinal graft versus host disease: first results of a prospective trial [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A82
  • 16 Moy L, Levine J. Wireless capsule endoscopy in the pediatric age group: experience and complications [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A73
  • 17 Spada C, Riccioni M, Spera G. et al . Is it possible to perform a safe video capsule endoscopy in patients with known intestinal stricture? [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A649
  • 18 Ramirez F C, Akins R, Shaukat M. String capsule endoscopy for the screening of Barrett’s esophagus in patients with chronic GERD: a prospective, blinded study [abstract].  Gastrointest Endosc. 2005;  61 (5) AB141
  • 19 Swain P, Mills T, Kelleher B. et al . Radiocontrolled movement of a robot endoscope in the human gastrointestinal tract [abstract].  Gastrointest Endosc. 2005;  61 (5) AB101
  • 20 Swain P, Mosse S, Mills T. et al . Development of wireless capsule endoscope mechanisms for brush cytology, tissue fluid aspiration and biopsy [abstract].  Gastrointest Endosc. 2005;  61 (5) AB106
  • 21 Andrews A H, Napierkowski J, Lake K. et al . Efficacy of bowel preparation in capsule endoscopy: a prospective, randomized, single-blinded controlled study [abstract].  Gastrointest Endosc. 2005;  61 (5) AB159
  • 22 Barnert J R, Messmann H. Can the measurement of the gastric emptying time of a solid test meal predict the residence time of a video capsule in the stomach? [abstract].  Gastrointest Endosc. 2005;  61 (5) AB160
  • 23 Ben Soussan E, Antonietti M, Ramirez S. et al . Modalities in performing capsule endoscopy: does it influence gastric retention? [abstract].  Gastrointest Endosc. 2005;  61 (5) AB160
  • 24 Chun H J, Kim Y S, Kim K J. et al . Factors that affect complete small bowel transit of capsule endoscope [abstract].  Gastrointest Endosc. 2005;  61 (5) AB171
  • 25 Dubner S, Dubner Y, Zagalsky D H. et al . Electromagnetic interference from wireless video-capsule endoscopy on implantable pacemakers [abstract].  Gastrointest Endosc. 2005;  61 (5) AB186
  • 26 Harvey A M, Nath S K, Raju G S. Capsule endoscopic imaging of the colon is not ready for prime time: lookout for a better prep [abstract].  Gastrointest Endosc. 2005;  61 (5) AB179
  • 27 Kim K J, Kim S H, Rho E J. Tegaserod increase colonic entry rate in patients undergoing capsule endoscopy [abstract].  Gastrointest Endosc. 2005;  61 (5) AB170
  • 28 Lai L H, Wong G L, Lau J Y. et al . Inter-observer variations on interpretation of capsule endoscopy [abstract].  Gastrointest Endosc. 2005;  61 (5) AB173
  • 29 Ponferrada A, Anton S, Gonzalez-Asanza C. et al . Interobserver agreement between experienced endoscopist and endoscopy nurse in the detection of lesions in the capsule endoscopy examination [abstract].  Gastrointest Endosc. 2005;  61 (5) AB178
  • 30 Ponferrada A, Gonzalez-Asanza C, Menchen L. et al . Predictive factors of incomplete capsule endoscopy examination [abstract].  Gastrointest Endosc. 2005;  61 (5) AB178
  • 31 Shiotani A, Opekun A R, Graham D Y. Improved visualization of the small intestine using capsule endoscopy [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A649
  • 32 Souquet J C, Bellecoste-Martin M, Belbouab S. et al . Prospective evaluation of the automatic location system during capsule endoscopy examination of the small intestine [abstract].  Gastrointest Endosc. 2005;  61 (5) AB182
  • 33 Urma D, Keroack M D, Kuo B. Single medical center report of complications following ingestion of video capsule endoscopy (VCE) with a new classification scheme [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A649
  • 34 Bergwerk A, Shapiro R, Reif S. et al . Capsule endoscopy in a series of preschool age children with obscure gastrointestinal bleeding [abstract].  Gastrointest Endosc. 2005;  61 (5) AB306
  • 35 Choi M G, Lee I S, Kim K J. et al . Multicenter retrospective evaluation of capsule endoscopy in obscure overt gastrointestinal bleeding in Korea [abstract].  Gastrointest Endosc. 2005;  61 (5) AB161
  • 36 De la Mora J G, Harewood G C, Gostout C J. Capsule endoscopy or push enteroscopy, which comes first for a patient with obscure gastrointestinal bleeding? A cost minimization analysis [abstract].  Gastrointest Endosc. 2005;  61 (5) AB150
  • 37 Dobozi B, Lin S, Patel K. et al . The clinical utility of wireless capsule endoscopy in patients with cirrhosis, varices and anemia [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A733
  • 38 Elijah D, Daas A, Brady P. Capsule endoscopy for obscure GI bleeding yields a high incidence of significant treatable lesions within reach of standard upper endoscopy [abstract].  Gastrointest Endosc. 2005;  61 (5) AB163
  • 39 Favre O, Daudet J, Jacob P. Clinical outcome of 41 patients with angiodysplasias of the small intestine visualized by capsule endoscopy: 11 months follow up [abstract].  Gastrointest Endosc. 2005;  61 (5) AB164
  • 40 Iwamoto M, Yamamoto H, Kita H. et al . Diagnostic and therapeutic strategy: combination of capsule endoscopy (CE) and double-balloon endoscopy (DBE) [abstract].  Gastrointest Endosc. 2005;  61 (5) AB167
  • 41 Iyngkaran G, Schoeman M, Nguyen N. et al . Impact of capsule endoscopy on demand and diagnostic yield of push enteroscopy [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A648
  • 42 Krauss N G, Hochberger J, Hahn E G. Prospective comparison of wireless capsule endoscopy (CE) with radionuclide dynamic scintiscan (RDS) or selective angiography (SA) in patients with acute gastrointestinal bleeding [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A648
  • 43 Langelier J, Cave D R. Diagnostic yield of video capsule endoscopy for obscure gastrointestinal bleeding: an evaluation of sequential cohorts [abstract].  Gastrointest Endosc. 2005;  61 (5) AB161
  • 44 Nath S K, Raju G S. Capsule endoscopic diagnosis of extra-intestinal bleeding [abstract].  Gastrointest Endosc. 2005;  61 (5) AB179
  • 45 Repici A, Pennazio M, Ottobrelli A. et al . Capsule endoscopy in cirrhotic patients: prevalence and spectrum of small bowel lesions [abstract].  Gastrointest Endosc. 2005;  61 (5) AB158
  • 46 Schmidt H, Hartmann D, Kinzel F. et al . Capsule endoscopy followed by intraoperative enteroscopy and therapy in patients with chronic gastrointestinal bleeding: long-term results of a prospective controlled multicentric trial [abstract].  Gastrointest Endosc. 2005;  61 AB 181
  • 47 Shapira S, Enns R, Yu E. Earlier implementation of capsule endoscopy for obscure gastrointestinal bleeding decreases resource utilization [abstract].  Gastrointest Endosc. 2005;  61 (5) AB181
  • 48 Shapira S, Yu E, Enns R. Capsule endoscopy: is there value of a negative study? [abstract].  Gastrointest Endosc. 2005;  61 (5) AB181
  • 49 Shiba M, Higuchi K, Kameda N. et al . Wireless capsule endoscopy and double-balloon enteroscopy in Japanese patients with obscure gastrointestinal bleeding [abstract].  Gastrointest Endosc. 2005;  61 (5) AB182
  • 50 Taller J, Lee C M, Feng J J. et al . Minimally invasive surgery as treatment of obscure GI bleeding and abdominal complaints can be effectively guided by video capsule endoscopy: a review of 28 patients [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A816
  • 51 Viazis N, Papaxoinis K, Theodoropoulos I. et al . Impact of capsule endoscopy in obscure gastrointestinal bleeding: defining strict diagnostic criteria for a favorable outcome [abstract].  Gastrointest Endosc. 2005;  61 (5) AB185
  • 52 Wong V, Law J, Enns R. et al . Predictors for positive outcomes in capsule endoscopy for the indication of obscure gastrointestinal bleeding [abstract].  Gastrointest Endosc. 2005;  61 (5) AB185
  • 53 Boivin M L, Voderholzer W, Ortner M. et al . Interobserver agreement of wireless capsule endoscopy in patients with Crohn’s disease [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A647
  • 54 Calabrese E, Bozzi R, Petruzziello C. et al . Videocapsule endoscopy (VCE) versus small intestine contrast ultrasound sonography (SICUS) for assessing Crohn’s disease postoperative recurrence: a prospective longitudinal study [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A646
  • 55 Fisher L, Takami M S. Correlation between capsule endoscopy findings and serologic markers in the diagnosis of small intestinal Crohn’s disease [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A647
  • 56 Mehdizadeh S, Chen G C, Enayati P J. et al . The diagnostic yield of wireless capsule enteroscopy (WCE) in patients with ulcerative colitis (UC) [abstract].  Gastrointest Endosc. 2005;  61 (5) AB175
  • 57 Mehdizadeh S, Chen G C, Enayati P J. et al . Utility of wireless capsule enteroscopy (WCE) in evaluating Crohn’s disease patients with abdominal symptoms [abstract].  Gastrointest Endosc. 2005;  61 (5) AB175
  • 58 Park C H, Kim K J, Kim Y H. et al . Utility of capsule endoscopy for the diagnosis and classification of Crohn’s disease: a multicenter study in a low incidence country, South Korea [abstract].  Gastrointest Endosc. 2005;  61 (5) AB178
  • 59 Pittman R H, Legnani P, Kornbluth A. et al . The value of capsule endoscopy (CE) in the evaluation of obscure GI bleeding (OGIB) in patients with Crohn’s disease (CD) [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A648
  • 60 Pons V, Nos P, Bastida G. et al . Videocapsule endoscopy versus colonoscopy for the diagnosis of postsurgical recurrence in Crohn’s disease (CD): a pilot study [abstract].  Gastrointest Endosc. 2005;  61 (5) AB159
  • 61 Voderholzer W A, Büning C, Boivin M. et al . Do Card15 mutations influence small-bowel lesions in Crohn’s disease? Analysis by wireless capsule enteroscopy [abstract].  Gastrointest Endosc. 2005;  61 (5) AB157
  • 62 Jarry M, Ben Soussan E, Bourreille A. et al . The value of wireless capsule enteroscopy (WCE) in indeterminate colitis [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A306
  • 63 Biagi F, Campanella J, Bianchi P I. et al . Wireless capsule endoscopy in the evaluation of small bowel mucosa trophism [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A646
  • 64 De Vitis I, Spada C, Ennas S. et al . Duodenoscopy and capsule endoscopy: a new method to “staging” coeliac disease [abstract].  Gastrointest Endosc. 2005;  61 (5) AB162
  • 65 Bailey A A, Debinski H, Appleyard M. et al . Diagnosis and outcome of small bowel tumors found by capsule endoscopy: a three centre Australian experience [abstract].  Gastrointest Endosc. 2005;  61 (5) AB159
  • 66 Delvaux M, Laurent V, Klopp I. et al . Intestinal tumors: frequently revealed by an obscure digestive bleeding (ODB) and more easily diagnosed by capsule endoscopy (VCE) [abstract].  Gastrointest Endosc. 2005;  61 (5) AB162
  • 67 Eliakim A, Karban A, Nahir M. et al . Capsule endoscopy (CE) is superior to ileocolonoscopy (IC) in detecting small bowel lesions in patients with seronegative spondyloarthropathies (SPA) [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A647
  • 68 Hartmann D, Erben P, Schilling D. et al . Frequency of small bowel polyps in patients with duodenal adenoma but without familial adenomatous polyposis [abstract].  Gastrointest Endosc. 2005;  61 (5) AB165
  • 69 Hewett D G, O’Neil J M, Gibbons J C. et al . A prospective comparison of capsule endoscopy, enteroclysis and enteroscopy in Peutz-Jeghers syndrome [abstract].  Gastrointest Endosc. 2005;  61 (5) AB166
  • 70 Maiden L, Thjodleifsson B, Theodors A. et al . NSAID enteropathy as seen by capsule endoscopy may resemble Crohn’s disease [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A242
  • 71 Mata A, Llach J, Castells A. et al . A prospective trial comparing wireless capsule endoscopy and barium contrast series for small bowel surveillance in hereditary polyposis syndromes [abstract].  Gastrointest Endosc. 2005;  61 (5) AB174
  • 72 Rodriguez S, Faigel D. Yield of capsule endoscopy compared to push enteroscopy for small bowel tumors [abstract].  Gastrointest Endosc. 2005;  61 (5) AB180
  • 73 Spada C, Dirozzi G, Iacopini F. et al . Diagnostic yield of capsule endoscopy in patients with chronic abdominal pain [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A649
  • 74 Tuyl S V, Stolk M, van Noorden J T. et al . Diagnostic value of video capsule endoscopy in carcinoid tumors [abstract].  Gastrointest Endosc. 2005;  61 (5) AB184
  • 75 Urbain D, De Looze D, Demets I. et al . Multicentric Belgian experience in the detection of small bowel malignancy by using video capsule endoscopy [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A649
  • 76 Villalona J, Kooros K, Rossi T. et al . Small bowel polyps and angiodysplasia discovered by video-capsule endoscopy in a ten-year-old with Peutz-Jeghers syndrome [abstract].  Gastrointest Endosc. 2005;  61 (5) AB309
  • 77 Boivin M L, Voderholzer W, Lochs H. Clinical relevance of the patency capsule in diagnosing strictures of the small bowel: results of a one year prospective follow-up study [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A646
  • 78 de Franchis R, Signorelli C, Villa E. et al . Evaluation of the M2A patency capsule in patients at high risk for capsule retention [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A647
  • 79 Delvaux M, Ben Soussan E, Laurent V. et al . Clinical evaluation of the “M2A Patency Capsule” system before a capsule endoscopy procedure (VCE), in patients with suspected intestinal stenosis [abstract].  Gastrointest Endosc. 2005;  61 (5) AB162
  • 80 Kitahara F, Enomoto N, Jutabha R. Evaluation of gastroesophageal reflux disease by capsule endoscopy [abstract].  Gastrointest Endosc. 2005;  61 (5) AB134
  • 81 Kozarek R, Schembre D, Lin O. et al . Sensitivity and accuracy of esophageal capsule endoscopy (ECE), versus conventional esophageal endoscopy (EG), in the identification of esophageal abnormalities in suspected chronic gastroesophageal reflux disease (GERD) [abstract].  Gastrointest Endosc. 2005;  61 (5) AB232
  • 82 Fritscher-Ravens A, Swain P, Mosse S. et al . Dumb-bell wireless capsule endoscopy [abstract].  Gastrointest Endosc. 2005;  61 (5) AB164
  • 83 Ogata H, Kumai K, Imaeda H. et al . The development of a new capsule endoscope: function-confirming test using animal model [abstract].  Gastrointest Endosc. 2005;  61 (5) AB77
  • 84 Fuerst F, Niv Y, Niv G. et al . Capsule endoscopy: experience of 779 consecutive examinations [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A647
  • 85 Raza M, Bernstein C N. The usefulness and impact on management of positive and negative capsule endoscopy [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A648
  • 86 Schenk G, Matthes H, Jeschke E. et al . Therapeutic yield of wireless capsule endoscopy (WCE) in small bowel diseases: a two-center follow-up study [abstract].  Gastroenterology. 2005;  128 (4 Suppl 2) A648

M. Pennazio, M. D.

Gastroenterology Unit 2, Dept. of Gastroenterology and Clinical Nutrition

S. Giovanni A.S. Hospital · Via Cavour 31 · 10123 Torino · Italy

Fax: +39-011-6333623

Email: mpen60@yahoo.com

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