Thorac Cardiovasc Surg 2018; 66(05): 384-389
DOI: 10.1055/s-0037-1606828
Original Thoracic
Georg Thieme Verlag KG Stuttgart · New York

Surgical Outcome of Colon Interposition in Esophageal Cancer Surgery: Analysis of Risk Factors for Conduit-Related Morbidity

Kanghoon Lee
1   Department of Thoracic and Cardiovascular Surgery, Pusan National University Yangsan Hospital, Yangsan, the Republic of Korea
,
Hyeong Ryul Kim
2   Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, the Republic of Korea
,
Seung-Il Park
2   Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, the Republic of Korea
,
Dong Kwan Kim
2   Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, the Republic of Korea
,
Yong-Hee Kim
2   Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, the Republic of Korea
,
Se Hoon Choi
2   Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, the Republic of Korea
› Author Affiliations
Further Information

Publication History

09 March 2017

16 August 2017

Publication Date:
09 October 2017 (online)

Abstract

Background We aimed to assess the feasibility, surgical outcomes, and conduit-related complications of colon interposition in patients with esophageal cancer.

Methods Patients with esophageal cancer who underwent colon interposition for esophageal reconstruction between June 2000 and June 2013 were retrospectively reviewed.

Results A total of 67 consecutive patients (mean age, 62.2 ± 7.9 years) were enrolled. During this time period, 944 patients underwent esophageal reconstruction using gastric conduit. Twelve patients (17.9%) also received neoadjuvant chemoradiotherapy (nCRT). The median follow-up duration was 44 months (range, 1–168 months); median survival duration was 63 months (range, 1–168 months); and 3- and 5-year overall survival rates were 61.6 and 49.4%, respectively. A total of 43 patients (64.2%) experienced at least 1 postoperative morbidity. According to the Clavien–Dindo grading system, 36 patients (54%) experienced postoperative morbidity of higher than Grade III. Pulmonary complications were most commonly observed complications among the patients (18 patients, 26.9%). Anastomosis site leakage developed in 11 patients (16.4%), and 3 of these patients (6.0%) eventually experienced graft failure. On multivariate analysis, nCRT was determined as a significant risk factor for conduit-related complications (leakage, graft failure, fistula, and stricture).

Conclusion Colon interposition is associated with relatively high complication rates, whereas nCRT is associated with conduit morbidity.

 
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