Lungenkrebs-Screening – Update 2014

 

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Einleitung

Nach wie vor stellt der Lungenkrebs weltweit die am häufigsten zum Tode führende Krebserkrankung dar [1]. Die späte Diagnosestellung ist beim Lungenkarzinom ein relevantes Problem, sodass die Notwendigkeit einer Früherkennung unumstritten ist. Die hierzu größte Studie wurde im November 2011 erstmals der Öffentlichkeit vorgestellt: Die Daten der National Lung Cancer Screening Trial (NLST) zeigten, dass durch die Anwendung eines jährlichen Screenings mit Niedrigdosis-Computertomografie (LCDT) eine 20%-ige relative Reduktion der Lungenkrebsmortalität erzielt werden kann [2]. Die Daten wurden ausgiebig diskutiert und führten zu einer ersten Stellungnahme deutscher Fachgesellschaften [3].

• Literatur

• 1 http://www.cancer.org/research/cancerfactsstatistics/cancerfactsfigures2014
  PubMed
• 2 Aberle DR, Adams AM, Berg CD et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011; 365: 395-409
  CrossrefPubMedGoogle Scholar
• 3 Vogelmeier C, Worth H, Pfeifer M et al. Joint statement of the German Respiratory Society and the German Roentgenological Society on the early detection of lung cancer by low-dose CT. Pneumologie 2011; 65: 5-6
  Article in Thieme ConnectPubMedGoogle Scholar
• 4 Finigan JH, Kern JA. Lung cancer screening: past, present and future. Clin Chest Med 2013; 34: 365-371
  CrossrefPubMedGoogle Scholar
• 5 Jett JR, Midthun DE. Screening for lung cancer: current status and future directions; Thomas A. Neff lecture. Chest 2004; 125 (Suppl): 158S-162S
  CrossrefPubMedGoogle Scholar
• 6 Bach PB, Kelley MJ, Tate RC et al. Screening for lung cancer: a review of the current literature. Chest 2003; 123 (Suppl): 72S-82S
  CrossrefPubMedGoogle Scholar
• 7 Saghir Z, Dirksen A, Ashraf H et al. CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT. Thorax 2012; 67: 296-301
  CrossrefPubMedGoogle Scholar
• 8 Infante M, Cavuto S, Lutman FR et al. DANTE Study Group. A randomized study of lung cancer screening with spiral computed tomography: three-year results from the DANTE trial. Am J Respir Crit Care Med 2009; 180: 445-453
  CrossrefPubMedGoogle Scholar
• 9 Pastorino U, Rossi M, Rosato V et al. Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial. Eur J Cancer Prev 2012; 21: 308-315
  CrossrefPubMedGoogle Scholar
• 10 §23 Röntgenverordnung. https://www.juris.de/purl/gesetze/_ges/RöV
  PubMedGoogle Scholar
• 11 Becker N, Motsch E, Gross ML et al. Randomized study on early detection of lung cancer with MSCT in Germany: study design and results of the first screening round. J Cancer Res Clin Oncol 2012; 138: 1475-1486
  CrossrefPubMedGoogle Scholar
• 12 http://www.uspreventiveservicestaskforce.org/uspstf13/lungcan/lungcanfinalrs.htm
  PubMed
• 13 http://www.lung.org/lung-disease/lung-cancer/lung-cancer-screening-guidelines/
  PubMed
• 14 Kovalchik SA, Tammemagi M, Berg CD et al. Targeting of low-dose CT screening according to the risk of lung-cancer death. N Engl J Med 2013; 369: 245-254
  CrossrefPubMedGoogle Scholar
• 15 Heuvers ME, Stricker BH, Aerts JG. Generalizing lung-cancer screening results. N Engl J Med 2012; 366: 192-193
  CrossrefPubMedGoogle Scholar
• 16 McCunney RJ, Li J. Radiation risks in lung cancer screening programs: a comparison with nuclear industry workers and atomic bomb survivors. Chest 2014; 145: 618-624
  CrossrefPubMedGoogle Scholar
• 17 Sommer G, Tremper J, Koenigkam-Santos M. Lung nodule detection in a high-risk population: comparison of magnetic resonance imaging and low-dose computed tomography. Eur J Radiol 2014; 83: 600-605
  CrossrefPubMedGoogle Scholar
• 18 Cromwell 1 J, Bartosch WJ, Fiore MC et al. Cost-effectiveness of the clinical practice recommendations in the AHCPR guideline for smoking cessation. Agency for Health Care Policy and Research. JAMA 1997; 278: 1759-1766
  CrossrefPubMedGoogle Scholar
• 19 van der Aalst CM, van den Bergh KA, Willemsen MC et al. Lung cancer screening and smoking abstinence: 2 year follow-up data from the Dutch-Belgian randomised controlled lung cancer screening trial. Thorax 2010; 65: 600-605
  CrossrefPubMedGoogle Scholar
• 20 Lüchtenborg M, Riaz SP, Coupland VH et al. High procedure volume is strongly associated with improved survival after lung cancer surgery. J Clin Oncol 2013; 31: 3141-3146
  CrossrefPubMedGoogle Scholar
• 21 http://www.krebsgesellschaft.de/wub_zertifizierung_krebszentren_lungenkrebs_liste,123705.html
  PubMed