Fortschr Neurol Psychiatr 2013; 81(11): 614-627
DOI: 10.1055/s-0033-1355843
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Die psychische Gesundheit von Kindern, Jugendlichen und jungen Erwachsenen – Teil 1: Häufigkeit, Störungspersistenz, Belastungsfaktoren, Service-Inanspruchnahme und Behandlungsverzögerung mit Konsequenzen

Mental Health of Children, Adolescents and Young Adults – Part 1: Prevalence, Illness Persistence, Adversities, Service use, Treatment Delay and Consequences
M. Lambert
1   Arbeitsbereich Psychosen, Klinik und Poliklinik für Psychiatrie und Psychotherapie, Zentrum für Psychosoziale Medizin, Universitätsklinikum Hamburg-Eppendorf (UKE)
,
T. Bock
1   Arbeitsbereich Psychosen, Klinik und Poliklinik für Psychiatrie und Psychotherapie, Zentrum für Psychosoziale Medizin, Universitätsklinikum Hamburg-Eppendorf (UKE)
,
D. Naber
1   Arbeitsbereich Psychosen, Klinik und Poliklinik für Psychiatrie und Psychotherapie, Zentrum für Psychosoziale Medizin, Universitätsklinikum Hamburg-Eppendorf (UKE)
,
B. Löwe
2   Institut und Poliklinik für Psychosomatische Medizin und Psychotherapie, Zentrum für Psychosoziale Medizin, Universitätsklinikum Hamburg-Eppendorf (UKE)
,
M. Schulte-Markwort
3   Klinik und Poliklinik für Kinder- und Jugendpsychiatrie und -psychotherapie, Zentrum für Psychosoziale Medizin, Universitätsklinikum Hamburg-Eppendorf (UKE)
,
I. Schäfer
4   Zentrum für Interdisziplinäre Suchtforschung (ZIS), Zentrum für Psychosoziale Medizin, Universitätsklinikum Hamburg-Eppendorf (UKE)
,
A. Gumz
2   Institut und Poliklinik für Psychosomatische Medizin und Psychotherapie, Zentrum für Psychosoziale Medizin, Universitätsklinikum Hamburg-Eppendorf (UKE)
,
P. Degkwitz
5   Center for Health Care Research (CHCR), Zentrum für Psychosoziale Medizin, Universitätsklinikum Hamburg-Eppendorf (UKE)
,
B. Schulte
4   Zentrum für Interdisziplinäre Suchtforschung (ZIS), Zentrum für Psychosoziale Medizin, Universitätsklinikum Hamburg-Eppendorf (UKE)
,
H. H. König
7   Institut für Medizinische Soziologie, Sozialmedizin und Gesundheitsökonomie (IMSG), Zentrum für Psychosoziale Medizin, Universitätsklinikum Hamburg-Eppendorf (UKE)
,
A. Konnopka
7   Institut für Medizinische Soziologie, Sozialmedizin und Gesundheitsökonomie (IMSG), Zentrum für Psychosoziale Medizin, Universitätsklinikum Hamburg-Eppendorf (UKE)
,
M. Bauer
8   Klinik und Poliklinik für Psychiatrie und Psychotherapie Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden
,
A. Bechdolf
9   Klinik für Psychiatrie und Psychotherapie, Universität zu Köln
10   Psychiatrie, Psychotherapie und Psychosomatik, Vivantes Klinikum Am Urban, Berlin
,
C. Correll
11   The Zucker Hillside Hospital, Division of Psychiatry Research, North Shore-LIJ Health System, Glen Oaks/ NY, USA
,
G. Juckel
12   Klinik für Pychiatrie, Psychotherapie und Präventivmedizin LWL-Universitätsklinikum der Ruhr-Universität Bochum
,
J. Klosterkötter
10   Psychiatrie, Psychotherapie und Psychosomatik, Vivantes Klinikum Am Urban, Berlin
,
K. Leopold
8   Klinik und Poliklinik für Psychiatrie und Psychotherapie Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden
,
A. Pfennig
8   Klinik und Poliklinik für Psychiatrie und Psychotherapie Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden
,
A. Karow
1   Arbeitsbereich Psychosen, Klinik und Poliklinik für Psychiatrie und Psychotherapie, Zentrum für Psychosoziale Medizin, Universitätsklinikum Hamburg-Eppendorf (UKE)
› Author Affiliations
Further Information

Publication History

Publication Date:
05 November 2013 (online)

Zusammenfassung

In einer Vielzahl von Geburtskohortenstudien, epidemiologischen Studien und klinischen Beobachtungsstudien wurden psychische Erkrankungen bei Kindern, Jugendlichen und jungen Erwachsenen in Bezug auf Häufigkeit, Ersterkrankungsalter, Belastungsfaktoren, Störungspersistenz, Service-Inanspruchnahme, Behandlungsverzögerung und Krankheitsverlauf untersucht. Eine Vielzahl von Publikationen befasste sich darüber hinaus mit den Konsequenzen psychischer Erkrankungen hinsichtlich der Krankheitslast, der Versorgungsdefizite sowie der Effektivität und Effizienz von „Early Intervention Services“. Die Ergebnisse zeigen, dass die Mehrzahl aller psychischen Erkrankungen bereits in der Kindheit, Jugend und im frühen Erwachsenenalter erstmals auftreten. Es lassen sich dabei kombinierte und dauerhafte Belastungsfaktoren nachweisen, die das Risiko, (früh und chronisch) psychisch zu erkranken, erhöhen. In der Kindheit und Jugend erstmals aufgetretene psychische Störungen persistieren häufig bis in das Erwachsenenalter. Als wesentliche Ursachen hierfür wurden eine niedrigere Inanspruchnahme von Behandlung und eine lange Behandlungsverzögerung mit verschiedenen negativen Konsequenzen sowie eine allgemein unzureichende Behandlungsqualität bei Kontakt zum Hilfesystem identifiziert. Zahlreiche andere Länder haben dementsprechend begonnen, an der Schnittstelle zwischen Kinder- und Jugend- und Erwachsenenpsychiatrie sog. „Early Intervention Services (EIS)“ zu implementieren. Das vorliegende Review Teil 1 befasst sich mit der Häufigkeit psychischer Erkrankungen, dem Ersterkrankungsalter, Belastungsfaktoren, der Störungspersistenz, Service-Inanspruchnahme und Behandlungsverzögerung und den Konsequenzen für Kinder, Jugendliche und junge Erwachsene.

Abstract

Numerous birth-control studies, epidemiological studies, and observational studies have investigated mental health and health care in childhood, adolescence and early adulthood, including prevalence, age at onset, adversities, illness persistence, service use, treatment delay and course of illness. Moreover, the impact of the burden of illness, of deficits of present health care systems, and the efficacy and effectiveness of early intervention services on mental health were evaluated. According to these data, most mental disorders start during childhood, adolescence and early adulthood. Many children, adolescents and young adults are exposed to single or multiple adversities, which increase the risk for (early) manifestations of mental diseases as well as for their chronicity. Early-onset mental disorders often persist into adulthood. Service use by children, adolescents and young adults is low, even lower than for adult patients. Moreover, there is often a long delay between onset of illness and first adequate treatment with a variety of linked consequences for a poorer psychosocial prognosis. This leads to a large burden of illness with respect to disability and costs. As a consequence several countries have implemented so-called “early intervention services” at the interface of child and adolescent and adult psychiatry. Emerging studies show that these health-care structures are effective and efficient. Part 1 of the present review summarises the current state of mental health in childhood, adolescence and early adulthood, including prevalence, age at onset, adversities, illness persistence, service use, and treatment delay with consequences.

 
  • Literatur

  • 1 Kessler RC, Angermeyer M, Anthony JC et al. Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization's World Mental Health Survey Initiative. World Psychiatry 2007; 6: 168-176
  • 2 Murray CJ, Lopez AD. The Global Burden of Disease. Geneva: WHO; 1996
  • 3 McGorry P, Purcell R, Hickie I et al. Investing in youth mental health is a best buy. Medical Journal of Australia 2007; 5: 187
  • 4 McGorry PD, Purcell R, Hickie IB et al. Clinical staging: a heuristic model for psychiatry and youth mental health. The Medical journal of Australia 2007; 187: S40-42
  • 5 McGorry P, Purcell R. Youth mental health reform and early intervention: encouraging early signs. Early intervention in psychiatry 2009; 3: 161-162
  • 6 Gore FM, Bloem PJ, Patton GC et al. Global burden of disease in young people aged 10-24 years: a systematic analysis. Lancet 2011; 377: 2093-2102
  • 7 Gustavsson A, Svensson M, Jacobi F et al. Cost of disorders of the brain in Europe 2010. European Neuropsychopharmacology 2011; 21: 718-779
  • 8 Kessler RC, Avenevoli S, Costello EJ et al. Prevalence, persistence, and sociodemographic correlates of DSM-IV disorders in the National Comorbidity Survey Replication Adolescent Supplement. Archives of general psychiatry 2012; 69: 372-380
  • 9 Merikangas KR, He JP, Burstein M et al. Lifetime prevalence of mental disorders in U. S. adolescents: results from the National Comorbidity Survey Replication – Adolescent Supplement (NCS-A). Journal of the American Academy of Child and Adolescent Psychiatry 2010; 49: 980-989
  • 10 Kessler RC, Avenevoli S, McLaughlin KA et al. Lifetime co-morbidity of DSM-IV disorders in the US National Comorbidity Survey Replication – Adolescent Supplement (NCS-A). Psychological medicine 2012; 42: 1997-2010
  • 11 Kessler R, Avenevoli S, Costello J et al. Severity of 12-month dsm-IV disorders in the national comorbidity survey replication adolescent supplement. Archives of general psychiatry 2012; 69: 381-389
  • 12 Moffitt TE, Caspi A, Taylor A et al. How common are common mental disorders? Evidence that lifetime prevalence rates are doubled by prospective versus retrospective ascertainment. Psychological medicine 2010; 40: 899-909
  • 13 Okkels N, Vernal D, Jensen S et al. Changes in the diagnosed incidence of early onset schizophrenia over four decades. Acta psychiatrica Scandinavica 2012; [Epub ahead of print]
  • 14 Goldney R, Eckert K, Hawthorne G et al. Changes in the prevalence of major depression in an Australian community sample between 1998 and 2008. The Australian and New Zealand journal of psychiatry 2010; 44: 901-910
  • 15 Kessler RC, Berglund P, Demler O et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of general psychiatry 2005; 62: 593-602
  • 16 Insel TR, Fenton WS. Psychiatric epidemiology: it's not just about counting anymore. Archives of general psychiatry 2005; 62: 590-592
  • 17 DEGS. Studie zur Gesundheit Erwachsener in Deutschland. . In: Robert Koch-Institut; 2012
  • 18 Angst J, Gamma A, Rossler W et al. Long-term depression versus episodic major depression: results from the prospective Zurich study of a community sample. Journal of affective disorders 2009; 115: 112-121
  • 19 Essau CA, Lewinsohn PM, Seeley JR et al. Gender differences in the developmental course of depression. Journal of affective disorders 2010; 127: 185-190
  • 20 Korczak DJ, Goldstein BI. Childhood onset major depressive disorder: course of illness and psychiatric comorbidity in a community sample. The Journal of pediatrics 2009; 155: 118-123
  • 21 Bromet E, Andrade LH, Hwang I et al. Cross-national epidemiology of DSM-IV major depressive episode. BMC medicine 2011; 9: 90
  • 22 Hetrick SE, Parker AG, Hickie IB et al. Early identification and intervention in depressive disorders: towards a clinical staging model. Psychotherapy and psychosomatics 2008; 77: 263-270
  • 23 Chengappa K, Kupfer D, Frank E. Relationship of birth cohort and early age at onset of illness in a bipolar disorder case registry. The American journal of psychiatry 2003; 160: 1636-1642
  • 24 Leverich GS, Post RM. Course of bipolar illness after history of childhood trauma. The Lancet 367: 1040-1042
  • 25 Post RM, Luckenbaugh DA, Leverich GS et al. Incidence of childhood-onset bipolar illness in the USA and Europe. Br J Psychiatry 2008; 192: 150-151
  • 26 Perlis RH, Miyahara S, Marangell LB et al. Long-Term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biological psychiatry 2004; 55: 875-881
  • 27 Hamshere ML, Gordon-Smith K, Forty L et al. Age-at-onset in bipolar-I disorder: Mixture analysis of 1369 cases identifies three distinct clinical sub-groups. Journal of affective disorders 2009; 116: 23-29
  • 28 Perlis RH, Dennehy EB, Miklowitz DJ et al. Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD study. Bipolar Disorders 2009; 11: 391-400
  • 29 Tijssen MJ, van Os J, Wittchen HU et al. Prediction of transition from common adolescent bipolar experiences to bipolar disorder: 10-year study. Br J Psychiatry 2010; 196: 102-108
  • 30 Baldessarini RJ, Bolzani L, Cruz N et al. Onset-age of bipolar disorders at six international sites. Journal of affective disorders 2010; 121: 143-146
  • 31 Merikangas K, Jin R, He J. Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Archives of general psychiatry 2011; 68: 241-251
  • 32 Drancourt N, Etain B, Lajnef M et al. Duration of untreated bipolar disorder: missed opportunities on the long road to optimal treatment. Acta psychiatrica Scandinavica 2013; 127: 136-144
  • 33 Altamura AC, Dell'Osso B, Berlin HA et al. Duration of untreated illness and suicide in bipolar disorder: a naturalistic study. European archives of psychiatry and clinical neuroscience 2010; 260: 385-391
  • 34 Jablensky A, Sartorius N, Ernberg G et al. Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychol Med Monogr Suppl 1992; 20: 1-97
  • 35 Häfner H. Gender differences in schizophrenia. Psychoneuroendocrinology 2003; 28: 17-54
  • 36 Thorup A, Waltoft BL, Pedersen CB et al. Young males have a higher risk of developing schizophrenia: a Danish register study. Psychological medicine 2007; 37: 479-484
  • 37 Lambert M, Conus P, Lubman DI et al. The impact of substance use disorders on clinical outcome in 643 patients with first-episode psychosis. Acta psychiatrica Scandinavica 2005; 112: 141-148
  • 38 Amminger GP, Henry LP, Harrigan SM et al. Outcome in early-onset schizophrenia revisited: findings from the Early Psychosis Prevention and Intervention Centre long-term follow-up study. Schizophrenia research 2011; 131: 112-119
  • 39 Schimmelmann BG, Conus P, Cotton S et al. Pre-treatment, baseline, and outcome differences between early-onset and adult-onset psychosis in an epidemiological cohort of 636 first-episode patients. Schizophrenia research 2007; 95: 1-8
  • 40 Esterberg ML, Trotman HD, Holtzman C et al. The impact of a family history of psychosis on age-at-onset and positive and negative symptoms of schizophrenia: A meta-analysis. Schizophrenia research 2010; 120: 121-130
  • 41 Large M, Sharma S, Compton MT et al. Cannabis use and earlier onset of psychosis: A systematic meta-analysis. Archives of general psychiatry 2011; 68: 555-561
  • 42 Kyriakopoulos M, Frangou S. Pathophysiology of early onset schizophrenia. International review of psychiatry (Abingdon, England) 2007; 19: 315-324
  • 43 Vyas NS, Patel NH, Puri BK. Neurobiology and phenotypic expression in early onset schizophrenia. Early intervention in psychiatry 2011; 5: 3-14
  • 44 Rajji TK, Ismail Z, Mulsant BH. Age at onset and cognition in schizophrenia: meta-analysis. Br J Psychiatry 2009; 195: 286-293
  • 45 Frangou S. Cognitive function in early onset schizophrenia: a selective review. Frontiers in Human Neuroscience 2009; 3: 79
  • 46 Paus T, Keshavan M, Giedd JN. Why do many psychiatric disorders emerge during adolescence?. Nature reviews 2008; 9: 947-957
  • 47 Walker EF, Sabuwalla Z, Huot R. Pubertal neuromaturation, stress sensitivity, and psychopathology. Dev Psychopathol 2004; 16 (04) 807-824
  • 48 Insel TR. Rethinking schizophrenia. Nature 2010; 468: 187-193
  • 49 Vega WA, Aguilar-Gaxiola S, Andrade L et al. Prevalence and age of onset for drug use in seven international sites: results from the international consortium of psychiatric epidemiology. Drug and alcohol dependence 2002; 68: 285-297
  • 50 Degenhardt L, Chiu WT, Sampson N et al. Toward a global view of alcohol, tobacco, cannabis, and cocaine use: findings from the WHO World Mental Health Surveys. PLoS medicine 2008; 5: e141
  • 51 Rutter M, Kim-Cohen J, Maughan B. Continuities and discontinuities in psychopathology between childhood and adult life. Journal of child psychology and psychiatry, and allied disciplines 2006; 47: 276-295
  • 52 Goodman A. Substance use and common child mental health problems: examining longitudinal associations in a British sample. Addiction 2010; 105: 1484-1496
  • 53 Slade EP, Stuart EA, Salkever DS et al. Impacts of age of onset of substance use disorders on risk of adult incarceration among disadvantaged urban youth: a propensity score matching approach. Drug and alcohol dependence 2008; 95: 1-13
  • 54 Behrendt S, Wittchen HU, Hofler M et al. Transitions from first substance use to substance use disorders in adolescence: is early onset associated with a rapid escalation?. Drug and alcohol dependence 2009; 99: 68-78
  • 55 Kuepper R, van Os J, Lieb R et al. Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study. Bmj 2011; 342: d738
  • 56 Rockhill C, Kodish I, DiBattisto C et al. Anxiety disorders in children and adolescents. Current problems in pediatric and adolescent health care 2010; 40: 66-99
  • 57 Roza SJ, Hofstra MB, van der Ende J et al. Stable prediction of mood and anxiety disorders based on behavioral and emotional problems in childhood: a 14-year follow-up during childhood, adolescence, and young adulthood. The American journal of psychiatry 2003; 160: 2116-2121
  • 58 Beesdo K, Pine DS, Lieb R et al. Incidence and risk patterns of anxiety and depressive disorders and categorization of generalized anxiety disorder. Archives of general psychiatry 2010; 67: 47-57
  • 59 Essau CA, Conradt J, Petermann F. Häufigkeit der Posttraumatischen Belastungsstörung bei Jugendlichen: Ergebnisse der Bremer Jugendstudie. Z Kinder Jugendpsychiatr Psychother 1999; 27: 37-45
  • 60 Häuser W, Schmutzer G, Brähler E et al. Misshandlungen in Kindheit und Jugend: Ergebnisse einer Umfrage in einer repräsentativen Stichprobe der deutschen Bevölkerung. Deutsches Ärzteblatt 2011; 108: 287-294
  • 61 Green JG, McLaughlin KA, Berglund PA et al. Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders. Archives of general psychiatry 2010; 67: 113-123
  • 62 Kingston S, Raghavan C. The relationship of sexual abuse, early initiation of substance use, and adolescent trauma to PTSD. Journal of traumatic stress 2009; 22: 65-68
  • 63 Sin GL, Abdin E, Lee J et al. Prevalence of post-traumatic stress disorder in first-episode psychosis. Early intervention in psychiatry 2010; 4: 299-304
  • 64 Kessler RC, Sonnega A, Bromet E et al. Posttraumatic stress disorder in the National Comorbidity Survey. Archives of general psychiatry 1995; 52: 1048-1060
  • 65 Perkonigg A, Kessler RC, Storz S et al. Traumatic events and post-traumatic stress disorder in the community: prevalence, risk factors and comorbidity. Acta psychiatrica Scandinavica 2000; 101: 46-59
  • 66 Widom CS. Posttraumatic stress disorder in abused and neglected children grown up. American Journal of Psychiatry 1999; 156: 1223-1229
  • 67 Kilpatrick DG, Ruggiero KJ, Acierno R et al. Violence and risk of PTSD, major depression, substance abuse/dependence, and comorbidity: results from the National Survey of Adolescents. Journal of consulting and clinical psychology 2003; 71: 692-700
  • 68 Kessler RC, McLaughlin KA, Green JG et al. Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. British Journal of Psychiatry 2010; 197: 378-385
  • 69 McLaughlin KA, Greif GreenJ, Gruber MJ et al. Childhood Adversities and First Onset of Psychiatric Disorders in a National Sample of US Adolescents. Archives of general psychiatry 2012; 69: 1151-1160
  • 70 Green JG, McLaughlin KA, Berglund PA et al. Childhood Adversities and Adult Psychiatric Disorders in the National Comorbidity Survey Replication I. Associations with first onset of DSM-IV Disorders. Archives of general psychiatry 2010; 67: 113-123
  • 71 Wille N, Bettge S, Ravens-Sieberer U. Risk and protective factors for children's and adolescents' mental health: results of the BELLA study. Eur Child Adolesc Psychiatry 2008; 17 (Suppl. 01) 133-147
  • 72 Patel V, Flisher AJ, Hetrick S et al. Mental health of young people: a global public-health challenge. Lancet 2007; 369: 1302-1313
  • 73 Konings M, Stefanis N, Kuepper R et al. Replication in two independent population-based samples that childhood maltreatment and cannabis use synergistically impact on psychosis risk. Psychological medicine 2012; 42: 149-159
  • 74 Chen LP, Murad MH, Paras ML et al. Sexual abuse and lifetime diagnosis of psychiatric disorders: systematic review and meta-analysis. Mayo Clinic Proceedings 2010; 85: 618-629
  • 75 Sugaya L, Hasin DS, Olfson M et al. Child physical abuse and adult mental health: a national study. Journal of traumatic stress 2012; 25
  • 76 Keyes KM, Eaton NR, Krueger RF et al. Childhood maltreatment and the structure of common psychiatric disorders. British Journal of Psychiatry 2012; 200: 107-115
  • 77 Cuijpers P, Smit F, Unger F et al. The disease burden of childhood adversities in adults: a population-based study. Child abuse & neglect 2011; 35: 937-945
  • 78 Fryers T, Melzer D, Jenkins R. Social inequalities and the common mental disorders: a systematic review of the evidence. Social psychiatry and psychiatric epidemiology 2003; 38: 229-237
  • 79 Maniglio R. The impact of child sexual abuse on health: a systematic review of reviews. Clinical psychology review 2009; 29: 647-657
  • 80 Hillberg T, Hamilton-Giachritsis C, Dixon L. Review of meta-analyses on the association between child sexual abuse and adult mental health difficulties: a systematic approach. Trauma Violence Abuse 2011; 12: 38-49
  • 81 Amaddeo F, Jones J. What is the impact of socio-economic inequalities on the use of mental health services?. Epidemiologia e psichiatria sociale 2007; 16: 16-19
  • 82 Amone-P’Olak K, Ormel J, Huisman M et al. Life stressors as mediators of the relation between socioeconomic position and mental health problems in early adolescence: the TRAILS study. Journal of the American Academy of Child and Adolescent Psychiatry 2009; 48: 1031-1038
  • 83 van Oort FV, van der Ende J, Wadsworth ME et al. Cross-national comparison of the link between socioeconomic status and emotional and behavioral problems in youths. Social psychiatry and psychiatric epidemiology 2011; 46: 167-172
  • 84 Clark C, Caldwell T, Power C et al. Does the influence of childhood adversity on psychopathology persist across the lifecourse? A 45-year prospective epidemiologic study. Annals of Epidemiology 2010; 20: 385-394
  • 85 McLaughlin KA, Green JG, Gruber MJ et al. Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication II: associations with persistence of DSM-IV disorders. Archives of general psychiatry 2010; 67: 124-132
  • 86 Scott KM, von Korff M, Angermeyer MC et al. Association of childhood adversities and early-onset mental disorders with adult-onset chronic physical conditions. Archives of general psychiatry 2011; 68: 838-844
  • 87 Stein DJ, Scott K, Haro AbadJM et al. Early childhood adversity and later hypertension: data from the World Mental Health Survey. Annals of Clinical Psychiatry 2010; 22: 19-28
  • 88 Flaherty EG, Thompson R, Litrownik AJ et al. Adverse childhood exposures and reported child health at age 12. Academia Pediatrica 2009; 9: 150-156
  • 89 Korkeila J, Lietzen R, Sillanmäki LH et al. Childhood adversities and adult-onset asthma: a cohort study. BMJ Open 2012; 14: 2
  • 90 Borges G, Nock MK, Haro AJM et al. Twelve-month prevalence of and risk factors for suicide attempts in the World Health Organization World Mental Health Surveys. Journal of Clinical Psychiatry 2010; 71: 1617-1628
  • 91 Bruffaerts R, Demyttenaere K, Borges G et al. Childhood adversities as risk factors for onset and persistence of suicidal behaviour. British Journal of Psychiatry 2010; 197: 20-27
  • 92 Meier-Gräwe U, Wagenknecht I. Expertise Kosten und Nutzen Früher Hilfen. Köln: Nationales Zentrum Frühe Hilfen; 2011
  • 93 de Girolamo G, Dagani J, Purcell R et al. Age of onset of mental disorders and use of mental health services: needs, opportunities and obstacles. Epidemiology and psychiatric sciences 2012; 21: 47-57
  • 94 Kessler RC, Angermeyer M, Anthony JC et al. Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization's World Mental Health Survey Initiative. World psychiatry: official journal of the World Psychiatric Association (WPA) 2007; 6: 168-176
  • 95 Cannon M, Caspi A, Moffitt TE et al. Evidence for early-childhood, pan-developmental impairment specific to schizo-phreniform disorder: results from a longitudinal birth cohort. Archives of general psychiatry 2002; 59: 449-456
  • 96 Kim-Cohen J, Caspi A, Moffitt TE et al. Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort. Archives of general psychiatry 2003; 60: 709-717
  • 97 Costello EJ, Mustillo S, Erkanli A et al. Prevalence and development of psychiatric disorders in childhood and adolescence. Archives of general psychiatry 2003; 60: 837-844
  • 98 McGue M, Iacono WG, Krueger R. The association of early adolescent problem behavior and adult Psychopathology: multivariate behavioral genetic perspective. Behaviour Genetics 2006; 36: 591-602
  • 99 Reef J, Diamantopoulou S, Van Meurs I et al. Child to adult continuities of psychopathology: a 24-year follow-up. Acta psychiatrica Scandinavica 2009; 120: 230-238
  • 100 Teplin LA, Welty LJ, Abram KM et al. Prevalence and persistence of psychiatric disorders in youth after detention: a prospective longitudinal study. Archives of general psychiatry 2012; 69: 1031-1043
  • 101 Lara C, Fayyad J, de Graaf R et al. Childhood predictors of adult attention-deficit/hyperactivity disorder: results from the World Health Organization World Mental Health Survey Initiative. Biological psychiatry 2009; 65: 46-54
  • 102 Biederman J, Petty CR, Evans M et al. How persistent is ADHD? A controlled 10-year follow-up study of boys with ADHD. Psychiatry research 2010; 177: 299-304
  • 103 Kim-Cohen J, Arseneault L, Newcombe R et al. Five-year predictive validity of DSM-IV conduct disorder research diagnosis in 4(1/2)-5-year-old children. European Child and Adolescent Psychiatry 2009; 18: 284-291
  • 104 Nock MK, Kazdin AE, Hiripi E et al. Lifetime prevalence, correlates, and persistence of oppositional defiant disorder: results from the National Comorbidity Survey Replication. The Journal of Child Psychology and Psychiatry 2007; 48: 703-713
  • 105 Nakatani E, Krebs G, Micali N et al. Children with very early onset obsessive-compulsive disorder: clinical features and treatment outcome. The Journal of Child Psychology and Psychiatry 2011; 52: 1261-1268
  • 106 Micali N, Heyman I, Perez M et al. Long-term outcomes of obsessive-compulsive disorder: follow-up of 142 children and adolescents. British Journal of Psychiatry 2010; 197: 128-134
  • 107 Beesdo-Baum K, Knappe S, Fehm L et al. The natural course of social anxiety disorder among adolescents and young adults. Acta psychiatrica Scandinavica 2012; 126: 411-425
  • 108 Rajeev J, Srinath S, Girimaji S et al. A systematic chart review of the naturalistic course and treatment of early-onset bipolar disorder in a child and adolescent psychiatry center. Comprehensive psychiatry 2004; 45: 148-154
  • 109 Wozniak J, Petty CR, Schreck M et al. High level of persistence of pediatric bipolar-I disorder from childhood onto adolescent years: a four year prospective longitudinal follow-up study. Journal of psychiatric research 2011; 45: 1273-1282
  • 110 Clemmensen L, Vernal DL, Steinhausen HC. A systematic review of the long-term outcome of early onset schizophrenia. BMC psychiatry 2012; 12: 150
  • 111 McDermott BM, Mamun AA, Najman JM et al. Longitudinal correlates of the persistence of irregular eating from age 5 to 14 years. Acta Paediatrica 2010; 99: 68-71
  • 112 Simonoff E, Jones CR, Baird G et al. The persistence and stability of psychiatric problems in adolescents with autism spectrum disorders. Journal of Child Psychology and Psychiatry 2012; :in press
  • 113 Knook LM, Lijmer JG, Konijnenberg AY et al. The course of chronic pain with and without psychiatric disorders: a 6-year follow-up study from childhood to adolescence and young adulthood. Journal of Clinical Psychiatry 2012; 73: 134-139
  • 114 Thornicroft G. Most people with mental illness are not treated. Lancet 2007; 370: 807-808
  • 115 Wang PS, Angermeyer M, Borges G et al. Delay and failure in treatment seeking after first onset of mental disorders in the World Health Organization's World Mental Health Survey Initiative. World Psychiatry 2007; 6: 177-185
  • 116 Alonso J, Angermeyer MC, Bernert S et al. Use of mental health services in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatrica Scandinavica Supplement 2004; 420: 47-54
  • 117 Pottick KJ, Bilder S, Vander StoepA et al. US patterns of mental health service utilization for transition-age youth and young adults. Journal of Behavioral Health Services and Research 2008; 35: 373-389
  • 118 Singh SP. Transition of care from child to adult mental health services: the great divide. Current opinion in psychiatry 2009; 22: 386-390
  • 119 Burgess PM, Pirkis JE, Slade TN et al. Service use for mental health problems: findings from the 2007 National Survey of Mental Health and Wellbeing. Australian and New Zealand Journal of Psychiatry 2009; 43: 615-623
  • 120 Lora A. Il Sistema di Salute Mentale della Regione Lombardia. Milano: Regione Lombardia; 2008
  • 121 Bignami R, Fioritti A, Lanciotti G et al. Rapporto 2008: Dati del Sistema Informativo dei Servizi di Salute Mentale dell’Emilia-Romagna Anno 2007. Bologna: Regione Emilia-Romagna; 2008
  • 122 Wang PS, Berglund P, Olfson M et al. Failure and delay in initial treatment contact after first onset of mental disorders in the National Comorbidity Survey Replication. Archives of general psychiatry 2005; 62: 603-613
  • 123 Christiana JM, Gilman SE, Guardino M et al. Duration between onset and time of obtaining initial treatment among people with anxiety and mood disorders: an international survey of members of mental health pa-tient advocate groups. Psychological medicine 2000; 30: 693-703
  • 124 Juul SH, Nemeroff CB. Psychiatric epidemiology. Handbook of Clinical Neurology 2012; 106: 167-189
  • 125 Boonstra N, Klaassen R, Sytema S et al. Duration of untreated psychosis and negative symptoms – A systematic review and meta-analysis of individual patient data. Schizophrenia research 2012; 142: 12-19
  • 126 Chang WC, Tang JY, Hui CL et al. Duration of untreated psychosis: Relationship with baseline characteristics and three-year outcome in first-episode psychosis. Psychiatry research 2012; 198: 360-365
  • 127 Cuesta MJ, García de Jalón E, Campos MS et al. Duration of untreated negative and positive symptoms of psychosis and cognitive im-pairment in first episode psychosis. Schizophrenia research 2012; 141: 222-227
  • 128 Lihong Q, Shimodera S, Fujita H et al. Duration of untreated psychosis in a rural/suburban region of Japan. Early intervention in psychiatry 2012; 6: 239-246
  • 129 Hill M, Crumlish N, Clarke M et al. Prospective relationship of duration of untreated psychosis to psychopathology and functional outcome over 12years. Schizophrenia research 2012; 141: 215-221
  • 130 Primavera D, Bandecchi C, Lepori T et al. Does duration of untreated psychosis predict very long term outcome of schizophrenic disorders? results of a retrospective study. Annals of General Psychiatry 2012; 11: 21
  • 131 Malla AK, Bodnar M, Joober R et al. Duration of untreated psychosis is associated with orbital-frontal grey matter volume reductions in first episode psychosis. Schizophrenia research 2011; 125: 13-20
  • 132 Cechnicki A, Hanuszkiewicz I, Polczyk R et al. Prognostic value of duration of untreated psychosis in long-term outcome of schizophrenia. Medical Science Monitor 2011; 17: 277-283
  • 133 Compton MT, Gordon TL, Goulding SM et al. Patient-level predictors and clinical correlates of duration of untreated psychosis among hospitalized first-episode patients. Journal of Clinical Psychiatry 2011; 72: 225-232
  • 134 Parellada M, Boada L, Fraguas D et al. Trait and state attributes of insight in first episodes of early-onset schizophrenia and other psychoses: a 2-year longitudinal study. Schizophrenia Bulletin 2011; 37: 38-51
  • 135 Penttilä M, Jääskeläinen E, Haapea M et al. Association between duration of untreated psychosis and brain morphology in schizophrenia within the Northern Finland 1966 Birth Cohort. Schizophrenia research 2010; 123: 145-152
  • 136 Owens DC, Johnstone EC, Miller P et al. Duration of untreated illness and outcome in schizophrenia: test of predictions in relation to relapse risk. British Journal of Psychiatry 2010; 196: 296-301
  • 137 Fusar-Poli P, Meneghelli A, Valmaggia L et al. Duration of untreated prodromal symptoms and 12-month functional outcome of individuals at risk of psychosis. British Journal of Psychiatry 2009; 194: 181-182
  • 138 Gaynor K, Dooley B, Lawlor E et al. Cognitive deterioration and duration of untreated psychosis. Early intervention in psychiatry 2009; 3: 157-160
  • 139 Farooq S, Large M, Nielssen O et al. The relationship between the duration of untreated psychosis and outcome in low-and-middle income countries: a systematic review and meta analysis. Schizophrenia research 2009; 109: 15-23
  • 140 Bangalore SS, Goradia DD, Nutche J et al. Untreated illness duration correlates with gray matter loss in first-episode psychoses. Neuroreport 2009; 20: 729-734
  • 141 Boden R, Sundstrom J, Lindstrom E et al. Association between symptomatic remission and functional outcome in first-episode schizophrenia. Schizophrenia research 2009; 107: 232-237
  • 142 Large M, Nielssen O. Evidence for a relationship between the duration of untreated psychosis and the proportion of psychotic homicides prior to treatment. Social psychiatry and psychiatric epidemiology 2008; 43: 37-44
  • 143 Barnes TR, Leeson VC, Mutsatsa SH et al. Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia. British Journal of Psychiatry 2008; 193: 203-209
  • 144 Schimmelmann BG, Huber CG, Lambert M et al. Impact of duration of untreated psychosis on pre-treatment, baseline, and outcome characteristics in an epidemiological first-episode psychosis cohort. Journal of psychiatric research 2008; 42: 982-990
  • 145 Lappin JM, Morgan KD, Morgan C et al. Duration of untreated psychosis and neuropsychological function in first episode psychosis. Schizophrenia research 2007; 95: 103-110
  • 146 Wade D, Harrigan S, McGorry PD et al. Impact of severity of substance use disorder on symptomatic and functional outcome in young individuals with first-episode psychosis. Journal of Clinical Psychiatry 2007; 68: 767-774
  • 147 Clarke M, Whitty P, Browne S et al. Untreated illness and outcome of psychosis. British Journal of Psychiatry 2006; 189: 235-240
  • 148 Wunderink A, Nienhuis FJ, Sytema S et al. Treatment delay and response rate in first episode psychosis. Acta psychiatrica Scandinavica 2006; 113: 332-339
  • 149 Malla A, Norman R, Schmitz N et al. Predictors of rate and time to remission in first-episode psychosis: a two-year outcome study. Psychological medicine 2006; 36: 649-658
  • 150 Lappin JM, Morgan K, Morgan C et al. Gray matter abnormalities associated with duration of untreated psychosis. Schizophrenia research 2006; 83: 145-153
  • 151 Marshall M, Lewis S, Lockwood A et al. Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Archives of general psychiatry 2005; 62: 975-983
  • 152 Gunduz-Bruce H, McMeniman M, Robinson DG et al. Duration of untreated psychosis and time to treatment response for delusions and hallucinations. American Journal of Psychiatry 2005; 162: 1966-1969
  • 153 Harris MG, Henry LP, Harrigan SM et al. The relationship between duration of untreated psychosis and outcome: an eight-year prospective study. Schizophrenia research 2005; 79: 85-93
  • 154 Melle I, Larsen TK, Haahr U. Reducing the duration of untreated first-episode psychosis: Effects on clinical presentation. Archives of general psychiatry 2004; 61: 143-150
  • 155 Perkins D, Lieberman J, Gu H et al. Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders. British Journal of Psychiatry 2004; 185: 18-24
  • 156 Addington J, Van Mastrigt S, Addington D. Duration of untreated psychosis: impact on 2-year outcome. Psychological medicine 2004; 34: 277-284
  • 157 Bottlender R, Sato T, Jäger M et al. The impact of the duration of untreated psychosis prior to first psychiatric admission on the 15-year outcome in schizophrenia. Schizophrenia research 2003; 62: 37-44
  • 158 Bottlender R, Sato T, Jäger M et al. The impact of duration of untreated psychosis and premorbid functioning on outcome of first inpatient treatment in schizophrenic and schizoaffective patients. European archives of psychiatry and clinical neuroscience 2002; 252: 226-231
  • 159 Altamura AC, Bassetti R, Sassella F et al. Duration of untreated psychosis as a predictor of outcome in first-episode schizophrenia: a retrospective study. Schizophrenia research 2001; 52: 29-36
  • 160 Altamura AC, Buoli M, Albano A et al. Age at onset and latency to treatment (duration of untreated illness) in patients with mood and anxiety disorders: a naturalistic study. International Clinical Psychopharmacology 2010; 25: 172-179
  • 161 Post RM, Leverich GS, Kupka RW et al. Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood. The Journal of clinical psychiatry 2010; 71: 864-872
  • 162 Okuda A, Suzuki T, Kishi T et al. Duration of untreated illness and antidepressant fluvoxamine response in major depressive disorder. Psychiatry and Clinical Neurosciences 2010; 64: 268-273
  • 163 de Diego-Adeliño J, Portella MJ, Puigdemont D et al. A short duration of untreated illness (DUI) improves response outcomes in first-depressive episodes. Journal of affective disorders 2010; 120: 221-225
  • 164 Altamura AC, Dell'Osso B, Mundo E et al. Duration of untreated illness in major depressive disorder: a naturalistic study. International Journal of Clinical Practice 2007; 61: 1697-1700
  • 165 Viswanath B, Narayanaswamy JC, Cherian AV et al. Is familial obsessive-compulsive disorder different from sporadic obsessive-compulsive disorder? A comparison of clinical characteristics, comorbidity and treatment response. Psychopathology 2011; 44: 83-89
  • 166 Altamura AC, Dell'Osso B, D'Urso N et al. Duration of untreated illness as a predictor of treatment response and clinical course in generalized anxiety disorder. CNS Spectrum 2008; 13: 415-422
  • 167 Altamura AC, Santini A, Salvadori D et al. Duration of untreated illness in panic disorder: a poor outcome risk factor?. Journal of Neuropsychiatric Disease and Treatment 2005; 1: 345-347