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J Neurol Surg B Skull Base 2013; 74(03): 118-125
DOI: 10.1055/s-0033-1347358
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses: A Meta-Analysis

Moran Amit
1   Department of Otolaryngology, Head and Neck Surgery, Rambam Medical Center, Haifa and Israel Institute of Technology, Technion, Haifa, Israel
,
Yoav Binenbaum
1   Department of Otolaryngology, Head and Neck Surgery, Rambam Medical Center, Haifa and Israel Institute of Technology, Technion, Haifa, Israel
,
Kanika Sharma
2   Department of Radiotherapy & Oncology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India
,
Ramer Naomi
3   Department of Pathology, Mount Sinai Medical Center, New York, New York, USA
,
Ramer Ilana
3   Department of Pathology, Mount Sinai Medical Center, New York, New York, USA
,
Agbetoba Abib
4   Department of Otolaryngology, The Mount Sinai School of Medicine, New York, New York, USA
,
Brett Miles
4   Department of Otolaryngology, The Mount Sinai School of Medicine, New York, New York, USA
,
Xinjie Yang
5   Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, P. R. China
,
Delin Lei
5   Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, P. R. China
,
Bjoerndal Kristine
6   Department of Otolaryngology Head and Neck Surgery, Odense University Hospital, Odense, Denmark
,
Godballe Christian
6   Department of Otolaryngology Head and Neck Surgery, Odense University Hospital, Odense, Denmark
,
Mücke Thomas
7   Department of Oral and Maxillofacial Surgery, Klinikum Rechts der Isar, Technische Universität München, München, Germany
,
Wolff Klaus-Dietrich
7   Department of Oral and Maxillofacial Surgery, Klinikum Rechts der Isar, Technische Universität München, München, Germany
,
Dan Fliss
8   Department of Otolaryngology Head and Neck Surgery, Tel Aviv Medical Center, Tel Aviv, Israel
,
André M. Eckardt
9   Department of Cranio-Maxillofacial Surgery, Hannover Medical School, Hannover, Germany
,
Copelli Chiara
10   Maxillo-Facial Surgery, University-Hospital of Parma, Parma, Italy
,
Enrico Sesenna
10   Maxillo-Facial Surgery, University-Hospital of Parma, Parma, Italy
,
Palmer Frank
11   Head and Neck Surgery Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
,
Snehal Patel
11   Head and Neck Surgery Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
,
Ziv Gil
1   Department of Otolaryngology, Head and Neck Surgery, Rambam Medical Center, Haifa and Israel Institute of Technology, Technion, Haifa, Israel
› Author Affiliations
Further Information

Publication History

21 November 2012

10 March 2013

Publication Date:
15 May 2013 (online)

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Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses: A Meta-AnalysisJ Neurol Surg B Skull Base 2014; 75(03): e1-e1
DOI: 10.1055/s-0034-1372486

Abstract

Objectives To identify independent predictors of outcome in patients with adenoid cystic carcinoma (ACC) of the paranasal sinuses and skull base.

Design Meta-analysis of the literature and data from the International ACC Study Group.

Setting University-affiliated medical center.

Participants The study group consisted of 520 patients, 99 of them from the international cohort. The median follow-up period was 60 months (range, 32 to 100 months).

Main Outcome Measures Overall survival (OS) and disease-specific survival (DSS).

Results The 5-year OS and DSS of the entire cohort were 62% and 67%, respectively. The local recurrence rate was 36.6%, and the regional recurrence rate was 7%. Distant metastasis, most commonly present in the lung, was recorded in 106 patients (29.1%). In the international cohort, positive margins and ACC of the sphenoid or ethmoidal sinuses were significant predictors of outcome (p < 0.001). Perineural invasion and adjuvant treatment (radiotherapy or chemoradiation) were not associated with prognosis.

Conclusion Tumor margin status and tumor site are associated with prognosis in ACC of the paranasal sinuses, whereas perineural invasion is not. Adjuvant treatment apparently has no impact on outcome.

Keywords

adenoid cystic carcinoma - paranasal sinuses - skull base - meta analysis - survival
 

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