Leitlinie zur Langzeit-Sauerstofftherapie^[*]

 

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Zusammenfassung

Die Langzeit-Sauerstofftherapie hat einen hohen Stellenwert sowohl zur Verminderung der Letalität als auch zur Verbesserung der Leistungsfähigkeit bei Patienten mit chronischen Lungenerkrankungen.

Die Grundvoraussetzung für die Langzeit-Sauerstofftherapie ist die adäquate Diagnostik und Indikationsstellung. Sinnvoll ist eine kausale Unterscheidung in eine chronische hypoxämische oder hyperkapnische respiratorische Insuffizienz, aus der sich die Differentialindikation zur nichtinvasiven Beatmung ergibt.

Die revidierte Leitlinie behandelt u. a. die Diagnostik und die Indikation bei chronischen Lungen- und Herzerkrankungen sowie den Einsatz in der Palliativmedizin und gibt eine detaillierte Beschreibung der verfügbaren Sauerstoffsysteme. Die Leitlinie soll dazu beitragen, die teilweise bestehende Unter-, Fehl- und Überversorgung zu vermeiden. Zudem wird im Kapitel „Postakute Sauerstofftherapie“ die im Alltag relevante, bisher nicht definierte Vorgehensweise für die Verschreibung einer Sauerstofftherapie am Ende eines stationären Aufenthaltes für den häuslichen Bereich diskutiert. Ein weiterer wichtiger Punkt, die korrekte Verordnung mobiler Sauerstoffsysteme, wird auch in der Leitlinie dargestellt. Die vorliegende aktualisierte Leitlinie zur Langzeit-Sauerstofftherapie löst die alte im Jahr 2008 publizierte Version ab.

Abstract

Long-term oxygen therapy is of great importance both for reducing mortality and for improving performance in patients with chronic lung diseases. The prerequisites for Long-term oxygen therapy are adequate diagnostics and clearly defined indication. A causal distinction into chronic hypoxaemic and hypercapnic respiratory failure is reasonable, from which the differential indication for non-invasive ventilation results.

The revised guideline covers the diagnostics and indication of chronic lung and heart diseases, the role of oxygen in terminal illness and gives a detailed description of available oxygen devices. The guideline is intended to help avoid undersupply, oversupply and false prescriptions. Furthermore, the chapter “Postacute Oxygen Therapy” discusses the procedure, relevant in everyday life, but not yet clearly defined, for prescribing oxygen therapy for the home at the end of an inpatient stay. Another important point, the correct prescription of mobile oxygen systems, is also presented in the guideline. This document is a revised version of the guideline for longterm oxygen therapy and replaces the version of 2008.

^* Verabschiedet von den Vorständen der beteiligten Fachgesellschaften am 27. 07. 2020.

Publication History

Article published online:
08 December 2020

© 2020. Thieme. All rights reserved.

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• 16 Literatur

• 1 Magnussen H, Kirsten AM, Köhler D. et al. Guidelines for long-term oxygen therapy. German Society for Pneumology and Respiratory Medicine. Pneumologie 2008; 62: 748-756
  Article in Thieme ConnectPubMedGoogle Scholar
• 2 www.awmf.org/leitlinien
  PubMed
• 3 Celli BR, MacNee W. ATS/ERS Task Force. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004; 23: 932-946
  CrossrefPubMedGoogle Scholar
• 4 Nocturnal Oxygen Therapy Trial Group. Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Ann Intern Med 1980; 93: 391-398
  CrossrefPubMedGoogle Scholar
• 5 Report of the Medical Research Council Working Party. Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Lancet 1981; 1: 681-686
  PubMedGoogle Scholar
• 6 Stoller JK, Panos RJ, Krachman S. et al. Oxygen therapy for patients with COPD: current evidence and the long-term oxygen treatment trial. Chest 2010; 138: 179-187
  CrossrefPubMedGoogle Scholar
• 7 Windisch W, Dreher M, Geiseler J. et al. Guidelines for Non-Invasive and Invasive Home Mechanical Ventilation for Treatment of Chronic Respiratory Failure – Update 2017. Pneumologie 2017; 71: 722-795
  Article in Thieme ConnectPubMedGoogle Scholar
• 8 Grassino A, Macklem PT. Respiratory muscle fatigue and ventilatory failure. Ann Rev Med 1984; 35: 625-647
  CrossrefPubMedGoogle Scholar
• 9 Bégin P, Grassino A. Inspiratory muscle dysfunction and chronic hypercapnia in chronic obstructive pulmonary disease. Am Rev Respir Dis 1991; 143: 905-912
  CrossrefPubMedGoogle Scholar
• 10 Vogelmeier C, Buhl R, Burghuber O. et al. Guideline for the Diagnosis and Treatment of COPD Patients – Issued by the German Respiratory Society and the German Atemwegsliga in Cooperation with the Austrian Society of Pneumology. Pneumologie 2018; 72: 253-308
  Article in Thieme ConnectPubMedGoogle Scholar
• 11 Magnet FS, Schwarz SB, Callegari J. et al. Long-Term Oxygen Therapy: Comparison of the German and British Guidelines. Respiration 2017; 93: 253-263
  CrossrefPubMedGoogle Scholar
• 12 Magnet FS, Storre JH, Windisch W. Home oxygen therapy: evidence versus reality. Expert Rev Respir Med 2017; 11: 425-441
  CrossrefPubMedGoogle Scholar
• 13 Górecka D, Gorzelak K, Sliwiński P. et al. Effect of long-term oxygen therapy on survival in patients with chronic obstructive pulmonary disease with moderate hypoxaemia. Thorax 1997; 52: 674-679
  CrossrefPubMedGoogle Scholar
• 14 Chaouat A, Weitzenblum E, Kessler R. et al. A randomized trial of nocturnal oxygen therapy in chronic obstructive pulmonary disease patients. Eur Respir J 1999; 14: 1002-1008
  CrossrefPubMedGoogle Scholar
• 15 Ekström M, Ringbaek T. Which patients with moderate hypoxemia benefit from long-term oxygen therapy? Ways forward. Int J Chron Obstruct Pulmon Dis 2018; 13: 231-235
  CrossrefPubMedGoogle Scholar
• 16 Hardinge M, Annandale J, Bourne S. et al. British Thoracic Society guidelines for home oxygen use in adults. Thorax 2015; 70: i1-43
  CrossrefPubMedGoogle Scholar
• 17 Muñoz X, Torres F, Sampol G. et al. Accuracy and reliability of pulse oximetry at different arterial carbon dioxide pressure levels. Eur Respir J 2008; 32: 1053-1059
  CrossrefPubMedGoogle Scholar
• 18 Roberts CM, Bugler JR, Melchor R. et al. Value of pulse oximetry in screening for long-term oxygen therapy requirement. Eur Respir J 1993; 6: 559-562
  CrossrefPubMedGoogle Scholar
• 19 Carlin BW, Clausen JL, Ries AL. The use of cutaneous oximetry in the prescription of long-term oxygen therapy. Chest 1988; 94: 239-241
  CrossrefPubMedGoogle Scholar
• 20 Zavorsky GS, Cao J, Mayo NE. et al. Arterial versus capillary blood gases: a meta-analysis. Respir Physiol Neurobiol 2007; 155: 268-279
  CrossrefPubMedGoogle Scholar
• 21 Roberts CM, Franklin J, OʼNeill A. et al. Screening patients in general practice with COPD for long-term domiciliary oxygen requirement using pulse oximetry. Respir Med 1998; 92: 1265-1268
  CrossrefPubMedGoogle Scholar
• 22 Eaton T, Rudkin S, Garrett JE. et al. The clinical utility of arterialized earlobe capillary blood in the assessment of patients for long-term oxygen therapy. Respir Med 2001; 95: 655-660
  CrossrefPubMedGoogle Scholar
• 23 Ekkernkamp E, Welte L, Schmoor C. et al. Spot check analysis of gas exchange: invasive versus noninvasive methods. Respiration 2015; 89: 294-303
  CrossrefPubMedGoogle Scholar
• 24 Pitkin AD, Roberts CM, Wedzicha JA. Arterialised earlobe blood gas analysis: an underused technique. Thorax 1994; 49: 364-366
  CrossrefPubMedGoogle Scholar
• 25 Fajac I, Texereau J, Rivoal V. et al. Blood gas measurement during exercise: a comparative study between arterialized earlobe sampling and direct arterial puncture in adults. Eur Respir J 1998; 11: 712-715
  CrossrefPubMedGoogle Scholar
• 26 Hughes JM. Blood gas estimations from arterialized capillary blood versus arterial puncture: are they different?. Eur Respir J 1996; 9: 184-185
  CrossrefPubMedGoogle Scholar
• 27 Dar K, Williams T, Aitken R. et al. Arterial versus capillary sampling for analysing blood gas pressures. BMJ 1995; 310: 24-25
  CrossrefPubMedGoogle Scholar
• 28 Sauty A, Uldry C, Debétaz LF. et al. Differences in PO₂ and PCO₂ between arterial and arterialized earlobe samples. Eur Respir J 1996; 9: 186-189
  CrossrefPubMedGoogle Scholar
• 29 Magnet FS, Majorski DS, Callegari J. et al. Capillary PO does not adequately reflect arterial PO in hypoxemic COPD patients. Int J Chron Obstruct Pulmon Dis 2017; 12: 2647-2653
  CrossrefPubMedGoogle Scholar
• 30 Diekmann M, Smidt U. Berechnung eines Standard-PaO₂ in Analogie zum Standard-Bikarbonat. Atemw Lungenkr 1984; 10: 248-260
  PubMedGoogle Scholar
• 31 Vergeret J, Brambilla C, Mounier L. Portable oxygen therapy: use and benefit in hypoxaemic COPD patients on long-term oxygen therapy. Eur Respir J 1989; 2: 20-25
  CrossrefPubMedGoogle Scholar
• 32 McKeon JL, Murree-Allen K, Saunders NA. Supplemental oxygen and quality of sleep in patients with chronic obstructive lung disease. Thorax 1989; 44: 184-188
  CrossrefPubMedGoogle Scholar
• 33 Fletcher EC, Donner CF, Midgren B. et al. Survival in COPD patients with a daytime PaO₂ greater than 60 mmHg with and without nocturnal oxyhemoglobin desaturation. Chest 1992; 101: 649-655
  CrossrefPubMedGoogle Scholar
• 34 Fletcher EC, Luckett RA, Goodnight-White S. et al. A double-blind trial of nocturnal supplemental oxygen for sleep desaturation in patients with chronic obstructive pulmonary disease and a daytime PaO₂ above 60 mmHg. Am Rev Respir Dis 1992; 145: 1070-1076
  CrossrefPubMedGoogle Scholar
• 35 Zinman R, Corey M, Coates AL. et al. Nocturnal home oxygen in the treatment of hypoxemic cystic fibrosis patients. J Pediatr 1989; 114: 368-377
  CrossrefPubMedGoogle Scholar
• 36 Spier S, Rivlin J, Hughes D. et al. The effect of oxygen on sleep, blood gases, and ventilation in cystic fibrosis. Am Rev Respir Dis 1984; 129: 712-718
  CrossrefPubMedGoogle Scholar
• 37 Gozal D. Nocturnal ventilatory support in patients with cystic fibrosis: comparison with supplemental oxygen. Eur Respir J 1997; 10: 1999-2003
  CrossrefPubMedGoogle Scholar
• 38 Vázquez JC, Pérez-Padilla R. Effect of oxygen on sleep and breathing in patients with interstitial lung disease at moderate altitude. Respiration 2001; 68: 584-589
  CrossrefPubMedGoogle Scholar
• 39 Krachman SL, Nugent T, Crocetti J. et al. Effects of oxygen therapy on left ventricular function in patients with Cheyne-Stokes respiration and congestive heart failure. J Clin Sleep Med 2005; 1: 271-276
  CrossrefPubMedGoogle Scholar
• 40 Javaheri S, Ahmed M, Parker TJ. et al. Effects of nasal O₂ on sleep-related disordered breathing in ambulatory patients with stable heart failure. Sleep 1999; 22: 1101-1106
  CrossrefPubMedGoogle Scholar
• 41 Hanly PJ, Millar TW, Steljes DG. et al. The effect of oxygen on respiration and sleep in patients with congestive heart failure. Ann Intern Med 1989; 111: 777-782
  CrossrefPubMedGoogle Scholar
• 42 Staniforth AD, Kinnear WJ, Starling R. et al. Effect of oxygen on sleep quality, cognitive function and sympathetic activity in patients with chronic heart failure and Cheyne-Stokes respiration. Eur Heart J 1998; 19: 922-928
  CrossrefPubMedGoogle Scholar
• 43 Andreas S, Clemens C, Sandholzer H. et al. Improvement of exercise capacity with treatment of Cheyne-Stokes respiration in patients with congestive heart failure. J Am Coll Cardiol 1996; 27: 1486-1490
  CrossrefPubMedGoogle Scholar
• 44 Broström A, Hubbert L, Jakobsson P. et al. Effects of long-term nocturnal oxygen treatment in patients with severe heart failure. J Cardiovasc Nurs 2005; 20: 385-396
  CrossrefPubMedGoogle Scholar
• 45 Paul B, Joseph M, De Pasquale CG. Domiciliary oxygen therapy improves sub-maximal exercise capacity and quality of life in chronic heart failure. Heart Lung Circ 2008; 17: 220-223
  CrossrefPubMedGoogle Scholar
• 46 Ahmadi Z, Sundh J, Bornefalk-Hermansson A. et al. Long-Term Oxygen Therapy 24 vs 15 h/day and Mortality in Chronic Obstructive Pulmonary Disease. PloS one 2016; 11: e0163293
  CrossrefPubMedGoogle Scholar
• 47 Sundh J, Ahmadi Z, Ekström M. Daily duration of long-term oxygen therapy and risk of hospitalization in oxygen-dependent COPD patients. Int J Chron Obstruct Pulmon Dis 2018; 13: 2623-2628
  CrossrefPubMedGoogle Scholar
• 48 Magnussen H, Hauck RW, Worth H. et al. Statement to long term oxygen therapy. Pneumologie 2014; 68: 591-593
  Article in Thieme ConnectPubMedGoogle Scholar
• 49 Singh D, Agusti A, Anzueto A. et al. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: the GOLD science committee report 2019. Eur Respir J 2019; 53: 1900164
  CrossrefPubMedGoogle Scholar
• 50 Coleta KD, Silveira LV, Lima DF. et al. Predictors of first-year survival in patients with advanced COPD treated using long-term oxygen therapy. Respir Med 2008; 102: 512-518
  CrossrefPubMedGoogle Scholar
• 51 Chambellan A, Chailleux E, Similowski T. Prognostic value of the hematocrit in patients with severe COPD receiving long-term oxygen therapy. Chest 2005; 128: 1201-1208
  CrossrefPubMedGoogle Scholar
• 52 Albert RK, Au DH. Long-Term Oxygen Treatment Trial Research Group. et al. A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation. N Engl J Med 2016; 375: 1617-1627
  CrossrefPubMedGoogle Scholar
• 53 Heaton RK, Grant I, McSweeny AJ. et al. Psychologic effects of continuous and nocturnal oxygen therapy in hypoxemic chronic obstructive pulmonary disease. Arch Intern Med 1983; 143: 1941-1947
  CrossrefPubMedGoogle Scholar
• 54 Jacobs SS, Lederer DJ, Garvey CM. et al. Optimizing Home Oxygen Therapy. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc 2018; 15: 1369-1381
  CrossrefPubMedGoogle Scholar
• 55 Moore RP, Berlowitz DJ, Denehy L. et al. A randomised trial of domiciliary, ambulatory oxygen in patients with COPD and dyspnoea but without resting hypoxaemia. Thorax 2011; 66: 32-37
  CrossrefPubMedGoogle Scholar
• 56 Drummond MB, Blackford AL, Benditt JO. et al. Continuous oxygen use in nonhypoxemic emphysema patients identifies a high-risk subset of patients: retrospective analysis of the National Emphysema Treatment Trial. Chest 2008; 134: 497-506
  CrossrefPubMedGoogle Scholar
• 57 Moy ML, Harrington KF, Sternberg AL. et al. Characteristics at the time of oxygen initiation associated with its adherence: Findings from the COPD Long-term Oxygen Treatment Trial. Respir Med 2019; 149: 52-58
  CrossrefPubMedGoogle Scholar
• 58 Paneroni M, Ambrosino N, Simonelli C. et al. Physical Activity in Patients with Chronic Obstructive Pulmonary Disease on Long-Term Oxygen Therapy: A Cross-Sectional Study. Int J Chron Obstruct Pulmon Dis 2019; 14: 2815-2823
  CrossrefPubMedGoogle Scholar
• 59 Casaburi R, Porszasz J, Hecht A. et al. Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapy. COPD 2012; 9: 3-11
  CrossrefPubMedGoogle Scholar
• 60 Guyatt GH, McKim DA, Austin P. et al. Appropriateness of domiciliary oxygen delivery. Chest 2000; 118: 1303-1308
  CrossrefPubMedGoogle Scholar
• 61 Douglas WW, Ryu JH, Schroeder DR. Idiopathic pulmonary fibrosis: Impact of oxygen and colchicine, prednisone, or no therapy on survival. Am J Respir Crit Care Med 2000; 161: 1172-1178
  CrossrefPubMedGoogle Scholar
• 62 Tomioka H, Imanaka K, Hashimoto K. et al. Health-related quality of life in patients with idiopathic pulmonary fibrosis – cross-sectional and longitudinal study. Intern Med 2007; 46: 1533-1542
  CrossrefPubMedGoogle Scholar
• 63 Swinburn CR, Mould H, Stone TN. et al. Symptomatic benefit of supplemental oxygen in hypoxemic patients with chronic lung disease. Am Rev Respir Dis 1991; 143: 913-915
  CrossrefPubMedGoogle Scholar
• 64 Harris-Eze AO, Sridhar G, Clemens RE. et al. Oxygen improves maximal exercise performance in interstitial lung disease. Am J Respir Crit Care Med 1994; 150: 1616-1622
  CrossrefPubMedGoogle Scholar
• 65 Visca D, Montgomery A, de Lauretis A. et al. Ambulatory oxygen in interstitial lung disease. Eur Respir J 2011; 38: 987-990
  CrossrefPubMedGoogle Scholar
• 66 Frank RC, Hicks S, Duck AM. et al. Ambulatory oxygen in idiopathic pulmonary fibrosis: of what benefit?. Eur Respir J 2012; 40: 269-270
  CrossrefPubMedGoogle Scholar
• 67 Sharp C, Adamali H, Millar AB. Ambulatory and short-burst oxygen for interstitial lung disease. Cochrane Database Syst Rev 2016; 7: CD011716
  PubMedGoogle Scholar
• 68 Bell EC, Cox NS, Goh N. et al. Oxygen therapy for interstitial lung disease: a systematic review. Eur Respir Rev 2017; 26(143): 160080
  CrossrefPubMedGoogle Scholar
• 69 Visca D, Mori L, Tsipouri V. et al. Effect of ambulatory oxygen on quality of life for patients with fibrotic lung disease (AmbOx): a prospective, open-label, mixed-method, crossover randomised controlled trial. Lancet Respir Med 2018; 6: 759-770
  CrossrefPubMedGoogle Scholar
• 70 Elphick HE, Mallory G. Oxygen therapy for cystic fibrosis. Cochrane Database Syst Rev 2013; 7: CD003884
  PubMedGoogle Scholar
• 71 Young AC, Wilson JW, Kotsimbos TC. et al. The impact of nocturnal oxygen desaturation on quality of life in cystic fibrosis. J Cyst Fibros 2011; 10: 100-106
  CrossrefPubMedGoogle Scholar
• 72 Smith PE, Edwards RH, Calverley PM. Oxygen treatment of sleep hypoxaemia in Duchenne muscular dystrophy. Thorax 1989; 44: 997-1001
  CrossrefPubMedGoogle Scholar
• 73 Leger P, Bedicam JM, Cornette A. et al. Nasal intermittent positive pressure ventilation. Long-term follow-up in patients with severe chronic respiratory insufficiency. Chest 1994; 105: 100-105
  CrossrefPubMedGoogle Scholar
• 74 Simonds AK, Elliott MW. Outcome of domiciliary nasal intermittent positive pressure ventilation in restrictive and obstructive disorders. Thorax 1995; 50: 604-609
  CrossrefPubMedGoogle Scholar
• 75 Buyse B, Meersseman W, Demedts M. Treatment of chronic respiratory failure in kyphoscoliosis: oxygen or ventilation?. Eur Respir J 2003; 22: 525-528
  CrossrefPubMedGoogle Scholar
• 76 Gustafson T, Franklin KA, Midgren B. et al. Survival of patients with kyphoscoliosis receiving mechanical ventilation or oxygen at home. Chest 2006; 130: 1828-1833
  CrossrefPubMedGoogle Scholar
• 77 Jäger L, Franklin KA, Midgren B. et al. Increased survival with mechanical ventilation in posttuberculosis patients with the combination of respiratory failure and chest wall deformity. Chest 2008; 133: 156-160
  CrossrefPubMedGoogle Scholar
• 78 Rose L, McKim D, Leasa D. et al. Patterns of healthcare utilisation for respiratory complications of adults with neuromuscular disease: a population study. Eur Respir J 2018; 3: 52
  PubMedGoogle Scholar
• 79 Windisch W. Donʼt forget about neuromuscular disorders!. Eur Respir J 2018; 3: 52
  PubMedGoogle Scholar
• 80 Köhnlein T, Windisch W, Köhler D. et al. Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial. Lancet Respir Med 2014; 2: 698-705
  CrossrefPubMedGoogle Scholar
• 81 Murphy PB, Rehal S, Arbane G. et al. Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation: A Randomized Clinical Trial. JAMA 2017; 317: 2177-2186
  CrossrefPubMedGoogle Scholar
• 82 Dubois P, Jamart J, Machiels J. et al. Prognosis of severely hypoxemic patients receiving long-term oxygen therapy. Chest 1994; 105: 469-474
  CrossrefPubMedGoogle Scholar
• 83 Riemann D, Baum E, Cohrs S. et al. S3-Leitlinie Nicht erholsamer Schlaf/Schlafstörungen. Somnologie 2017; 21: 2-44
  CrossrefPubMedGoogle Scholar
• 84 Ponikowski P, Voors AA, Anker SD. et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 2016; 18: 891-975
  CrossrefPubMedGoogle Scholar
• 85 Clark AL, Johnson M, Fairhurst C. et al. Does home oxygen therapy (HOT) in addition to standard care reduce disease severity and improve symptoms in people with chronic heart failure? A randomised trial of home oxygen therapy for patients with chronic heart failure. Health Technol Assess 2015; 19: 1-120
  CrossrefPubMedGoogle Scholar
• 86 Arzt M, Woehrle H, Oldenburg O. et al. Prevalence and Predictors of Sleep-Disordered Breathing in Patients With Stable Chronic Heart Failure: The SchlaHF Registry. JACC Heart Fail 2016; 4: 116-125
  CrossrefPubMedGoogle Scholar
• 87 Arzt M, Oldenburg O, Graml A. et al. Phenotyping of Sleep-Disordered Breathing in Patients With Chronic Heart Failure With Reduced Ejection Fraction-the SchlaHF Registry. J Am Heart Assoc 2017; 6(12): PMID:29187390
  PubMedGoogle Scholar
• 88 Mayer G, Arzt M, Braumann B. et al. German S3 Guideline Nonrestorative Sleep/Sleep Disorders, chapter “Sleep-Related Breathing Disorders in Adults,” short version: German Sleep Society (Deutsche Gesellschaft für Schlafforschung und Schlafmedizin, DGSM). Somnologie 2017; 21: 290-301
  CrossrefPubMedGoogle Scholar
• 89 Andreas S, Bingeli C, Mohacsi P. et al. Nasal oxygen and muscle sympathetic nerve activity in heart failure. Chest 2003; 123: 366-371
  CrossrefPubMedGoogle Scholar
• 90 Oldenburg O, Wellmann B, Buchholz A. et al. Nocturnal hypoxaemia is associated with increased mortality in stable heart failure patients. Eur Heart J 2016; 37: 1695-1703
  CrossrefPubMedGoogle Scholar
• 91 Randerath W, Verbraecken J, Andreas S. et al. Definition, discrimination, diagnosis and treatment of central breathing disturbances during sleep. Eur Respir J 2017; 49: 1600959 DOI: 10.1183/13993003.00959-2016.
  CrossrefPubMedGoogle Scholar
• 92 Cowie MR, Woehrle H, Wegscheider K. et al. Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure. N Engl J Med 2015; 373: 1095-1105
  CrossrefPubMedGoogle Scholar
• 93 Galiè N, Humbert M, Vachiery JL. et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Respir J 2015; 46: 903-975
  CrossrefPubMedGoogle Scholar
• 94 Meyer FJ, Ewert R, Hoeper MM. et al. Peripheral airway obstruction in primary pulmonary hypertension. Thorax 2002; 57: 473-476
  CrossrefPubMedGoogle Scholar
• 95 Sun XG, Hansen JE, Oudiz RJ. et al. Pulmonary function in primary pulmonary hypertension. J Am Coll Cardiol 2003; 41: 1028-1035
  CrossrefPubMedGoogle Scholar
• 96 Hoeper MM, Pletz MW, Golpon H. et al. Prognostic value of blood gas analyses in patients with idiopathic pulmonary arterial hypertension. Eur Respir J 2007; 29: 944-950
  CrossrefPubMedGoogle Scholar
• 97 Jilwan FN, Escourrou P, Garcia G. et al. High occurrence of hypoxemic sleep respiratory disorders in precapillary pulmonary hypertension and mechanisms. Chest 2013; 143: 47-55
  CrossrefPubMedGoogle Scholar
• 98 Rafanan AL, Golish JA, Dinner DS. et al. Nocturnal hypoxemia is common in primary pulmonary hypertension. Chest 2001; 120: 894-899
  CrossrefPubMedGoogle Scholar
• 99 Hoeper MM, Vonk-Noordegraaf A. Is there a vanishing pulmonary capillary syndrome?. Lancet Respir Med 2017; 5: 676-678
  CrossrefPubMedGoogle Scholar
• 100 Ulrich S, Keusch S, Hildenbrand FF. et al. Effect of nocturnal oxygen and acetazolamide on exercise performance in patients with pre-capillary pulmonary hypertension and sleep-disturbed breathing: randomized, double-blind, cross-over trial. Eur Heart J 2015; 36: 615-623
  CrossrefPubMedGoogle Scholar
• 101 Ulrich S, Hasler ED, Saxer S. et al. Effect of breathing oxygen-enriched air on exercise performance in patients with precapillary pulmonary hypertension: randomized, sham-controlled cross-over trial. Eur Heart J 2017; 38: 1159-1168
  CrossrefPubMedGoogle Scholar
• 102 Grünig E, Benjamin N, Krüger U. et al. General and supportive therapy of pulmonary arterial hypertension. Dtsch Med Wochenschr 2016; 141: S26-S32
  Article in Thieme ConnectPubMedGoogle Scholar
• 103 Grünig E, Benjamin N, Krüger U. et al. General measures and supportive therapy for pulmonary arterial hypertension: Updated recommendations from the Cologne Consensus Conference 2018. Int J Cardiol 2018; 272S: 30-36
  CrossrefPubMedGoogle Scholar
• 104 Sandoval J, Aguirre JS, Pulido T. et al. Nocturnal oxygen therapy in patients with the Eisenmenger syndrome. Am J Respir Crit Care Med 2001; 164: 1682-1687
  CrossrefPubMedGoogle Scholar
• 105 Bradley JM, Lasserson T, Elborn S. et al. A systematic review of randomized controlled trials examining the short-term benefit of ambulatory oxygen in COPD. Chest 2007; 131: 278-285
  CrossrefPubMedGoogle Scholar
• 106 Uronis HE, Ekström MP, Currow DC. et al. Oxygen for relief of dyspnoea in people with chronic obstructive pulmonary disease who would not qualify for home oxygen: a systematic review and meta-analysis. Thorax 2015; 70: 492-494
  CrossrefPubMedGoogle Scholar
• 107 Ameer F, Carson KV, Usmani ZA. et al. Ambulatory oxygen for people with chronic obstructive pulmonary disease who are not hypoxaemic at rest. Cochrane Database Syst Rev 2014; 6: CD000238
  PubMedGoogle Scholar
• 108 Ekström M, Ahmadi Z, Bornefalk-Hermansson A. et al. Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen therapy. Cochrane Database Syst Rev 2016; 11: CD006429
  PubMedGoogle Scholar
• 109 Jindal SK. Long term oxygen therapy-it is still relevant?. J Thorac Dis 2017; 9: E266-E268
  CrossrefPubMedGoogle Scholar
• 110 Nonoyama ML, Brooks D, Guyatt GH. et al. Effect of oxygen on health quality of life in patients with chronic obstructive pulmonary disease with transient exertional hypoxemia. Am J Respir Crit Care Med 2007; 176: 343-349
  CrossrefPubMedGoogle Scholar
• 111 Sandland CJ, Morgan MD, Singh SJ. Patterns of domestic activity and ambulatory oxygen usage in COPD. Chest 2008; 134: 753-760
  CrossrefPubMedGoogle Scholar
• 112 Ringbaek T, Martinez G, Lange P. The long-term effect of ambulatory oxygen in normoxaemic COPD patients: a randomised study. Chron Respir Dis 2013; 10: 77-84
  CrossrefPubMedGoogle Scholar
• 113 Héraud N, Préfaut C, Durand F. et al. A Does correction of exercise-induced desaturation by O(2) always improve exercise tolerance in COPD? A preliminary study. Respir Med 2008; 102: 1276-1286
  CrossrefPubMedGoogle Scholar
• 114 Lacasse Y, Lecours R, Pelletier C. et al. Randomised trial of ambulatory oxygen in oxygen-dependent COPD. Eur Respir J 2005; 25: 1032-1038
  CrossrefPubMedGoogle Scholar
• 115 Eaton T, Garrett JE, Young P. et al. Ambulatory oxygen improves quality of life of COPD patients: a randomised controlled study. Eur Respir J 2002; 20: 306-312
  CrossrefPubMedGoogle Scholar
• 116 McDonald CF, Blyth CM, Lazarus MD. et al. Exertional oxygen of limited benefit in patients with chronic obstructive pulmonary disease and mild hypoxemia. Am J Respir Crit Care Med 1995; 152: 1616-1619
  CrossrefPubMedGoogle Scholar
• 117 Hardinge M, Suntharalingam J, Wilkinson T. Guideline update: The British Thoracic Society Guidelines on home oxygen use in adults. Thorax 2015; 70: 589-591
  CrossrefPubMedGoogle Scholar
• 118 Arnold E, Bruton A, Donovan-Hall M. et al. Ambulatory oxygen: why do COPD patients not use their portable systems as prescribed? A qualitative study. BMC Pulm Med 2011; 11: 9
  CrossrefPubMedGoogle Scholar
• 119 Beasley R, Chien J, Douglas J. et al. Target oxygen saturation range: 92–96 % versus 94–98. Respirology 2017; 22: 200-202
  CrossrefPubMedGoogle Scholar
• 120 Crisafulli E, Costi S, De Blasio F. et al. Effects of a walking aid in COPD patients receiving oxygen therapy. Chest 2007; 131: 1068-1074
  CrossrefPubMedGoogle Scholar
• 121 Katsenos S, Constantopoulos SH. Long-Term Oxygen Therapy in COPD: Factors Affecting and Ways of Improving Patient Compliance. Pulm Med 2011; 2011: 325-362
  CrossrefPubMedGoogle Scholar
• 122 Casanova C, Cote C, Marin JM. et al. Distance and oxygen desaturation during the 6-min walk test as predictors of long-term mortality in patients with COPD. Chest 2008; 134: 746-752
  CrossrefPubMedGoogle Scholar
• 123 Somfay A, Porszasz J, Lee SM. et al. Dose-response effect of oxygen on hyperinflation and exercise endurance in nonhypoxaemic COPD patients. Eur Respir J 2001; 18: 77-84
  CrossrefPubMedGoogle Scholar
• 124 Jarosch I, Gloeckl R, Damm E. et al. Short-term Effects of Supplemental Oxygen on 6-Min Walk Test Outcomes in Patients With COPD: A Randomized, Placebo-Controlled, Single-blind, Crossover Trial. Chest 2017; 151: 795-803
  CrossrefPubMedGoogle Scholar
• 125 Dyer F, Callaghan J, Cheema K. et al. Ambulatory oxygen improves the effectiveness of pulmonary rehabilitation in selected patients with chronic obstructive pulmonary disease. Chron Respir Dis 2012; 9: 83-91
  CrossrefPubMedGoogle Scholar
• 126 Alison JA, McKeough ZJ, Leung RWM. et al. Oxygen compared to air during exercise training in COPD with exercise-induced desaturation. Eur Respir J 2019; 53: 1802429
  CrossrefPubMedGoogle Scholar
• 127 Emtner M, Porszasz J, Burns M. et al. Benefits of supplemental oxygen in exercise training in nonhypoxemic chronic obstructive pulmonary disease patients. Am J Respir Crit Care Med 2003; 168: 1034-1042
  CrossrefPubMedGoogle Scholar
• 128 Spielmanns M, Fuchs-Bergsma C, Winkler A. et al. Effects of Oxygen Supply During Training on Subjects With COPD Who Are Normoxemic at Rest and During Exercise: A Blinded Randomized Controlled Trial. Respir Care 2015; 60: 540-548
  CrossrefPubMedGoogle Scholar
• 129 Neunhäuserer D, Steidle-Kloc E, Weiss G. Supplemental Oxygen During High-Intensity Exercise Training in Nonhypoxemic Chronic Obstructive Pulmonary Disease. Am J Med 2016; 129: 1185-1193
  CrossrefPubMedGoogle Scholar
• 130 Frat JP, Thille AW, Mercat A. et al. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 2015; 372: 2185-2196
  CrossrefPubMedGoogle Scholar
• 131 Spoletini G, Alotaibi M, Blasi F. et al. Heated Humidified High-Flow Nasal Oxygen in Adults: Mechanisms of Action and Clinical Implications. Chest 2015; 148: 253-261
  CrossrefPubMedGoogle Scholar
• 132 Nishimura M. High-Flow Nasal Cannula Oxygen Therapy in Adults: Physiological Benefits, Indication, Clinical Benefits, and Adverse Effects. Respir Care 2016; 61: 529-541
  CrossrefPubMedGoogle Scholar
• 133 Pisani L, Fasano L, Corcione N. et al. Change in pulmonary mechanics and the effect on breathing pattern of high flow oxygen therapy in stable hypercapnic COPD. Thorax 2017; 72: 373-375
  CrossrefPubMedGoogle Scholar
• 134 Nielsen KR, Ellington LE, Gray AJ. et al. Effect of High-Flow Nasal Cannula on Expiratory Pressure and Ventilation in Infant, Pediatric, and Adult Models. Respir Care 2018; 63: 147-157
  CrossrefPubMedGoogle Scholar
• 135 Mauri T, Galazzi A, Binda F. et al. Impact of flow and temperature on patient comfort during respiratory support by high-flow nasal cannula. Crit Care 2018; 22: 120
  CrossrefPubMedGoogle Scholar
• 136 Storgaard LH, Hockey HU, Laursen BS. et al. Long-term effects of oxygen-enriched high-flow nasal cannula treatment in COPD patients with chronic hypoxemic respiratory failure. Int J Chron Obstruct Pulmon Dis 2018; 13: 1195-1205
  CrossrefPubMedGoogle Scholar
• 137 Bräunlich J, Seyfarth HJ, Wirtz H. Nasal High-flow versus non-invasive ventilation in stable hypercapnic COPD: a preliminary report. Multidiscip Respir Med 2015; 10: 27
  CrossrefPubMedGoogle Scholar
• 138 Bräunlich J, Dellweg D, Bastian A. et al. Nasal high-flow versus noninvasive ventilation in patients with chronic hypercapnic COPD. Int J Chron Obstruct Pulmon Dis 2019; 14: 1411-1421
  CrossrefPubMedGoogle Scholar
• 139 Booth S, Wade R, Johnson M. et al. The use of oxygen in the palliation of breathlessness. A report of the expert working group of the Scientific Committee of the Association of Palliative Medicine. Respir Med 2004; 98: 66-77
  CrossrefPubMedGoogle Scholar
• 140 Ripamonti C, Bruera E. Dyspnea: pathophysiology and assessment. J Pain Symptom Manage 1997; 13: 220-232
  CrossrefPubMedGoogle Scholar
• 141 Deutsche Krebsgesellschaft, Deutsche Krebshilfe, AWMF. Palliativmedizin für Patienten mit einer nicht-heilbaren Krebserkrankung, Langversion 2.1, 2020, AWMF-Registernummer: 128/001OL. https://www.leitlinienprogramm-onkologie.de/leitlinien/palliativmedizin/
  PubMedGoogle Scholar
• 142 OʼDriscoll BR, Neill J, Pulakal S. et al. A crossover study of short burst oxygen therapy (SBOT) for the relief of exercise-induced breathlessness in severe COPD. BMC Pulm Med 2011; 11: 23
  CrossrefPubMedGoogle Scholar
• 143 Abernethy AP, McDonald CF, Frith PA. et al. Effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea: a double-blind, randomised controlled trial. Lancet 2010; 376: 784-793
  CrossrefPubMedGoogle Scholar
• 144 Clemens KE, Quednau I, Klaschik E. Use of oxygen and opioids in the palliation of dyspnoea in hypoxic and non-hypoxic palliative care patients: a prospective study. Support Care Cancer 2009; 17: 367-377
  CrossrefPubMedGoogle Scholar
• 145 Currow DC, Agar M, Smith J. et al. Does palliative home oxygen improve dyspnoea? A consecutive cohort study. Palliat Med 2009; 23: 309-316
  CrossrefPubMedGoogle Scholar
• 146 Philip J, Gold M, Milner A. et al. A randomized, double-blind, crossover trial of the effect of oxygen on dyspnea in patients with advanced cancer. J Pain Symptom Manage 2006; 32: 541-550
  CrossrefPubMedGoogle Scholar
• 147 Uronis HE, Currow DC, McCrory DC. et al. Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis. Br J Cancer 2008; 98: 294-299
  CrossrefPubMedGoogle Scholar
• 148 Stevenson NJ, Calverley PM. Effect of oxygen on recovery from maximal exercise in patients with chronic obstructive pulmonary disease. Thorax 2004; 59: 668-672
  CrossrefPubMedGoogle Scholar
• 149 Lewis CA, Eaton TE, Young P. et al. Short-burst oxygen immediately before and after exercise is ineffective in nonhypoxic COPD patients. Eur Respir J 2003; 22: 584-588
  CrossrefPubMedGoogle Scholar
• 150 Garrod R, Paul EA, Wedzicha JA. Supplemental oxygen during pulmonary rehabilitation in patients with COPD with exercise hypoxaemia. Thorax 2000; 55: 539-543
  CrossrefPubMedGoogle Scholar
• 151 Rooyackers JM, Dekhuijzen PN, Van Herwaarden CL. et al. Training with supplemental oxygen in patients with COPD and hypoxaemia at peak exercise. Eur Respir J 1997; 10: 1278-1284
  CrossrefPubMedGoogle Scholar
• 152 Davidson PM, Johnson MJ. Update on the role of palliative oxygen. Curr Opin Support Palliat Care 2011; 5: 87-91
  CrossrefPubMedGoogle Scholar
• 153 Galbraith S, Fagan P, Perkins P. et al. Does the use of a handheld fan improve chronic dyspnea? A randomized, controlled, crossover trial. J Pain Symptom Manage 2010; 39: 831-838
  CrossrefPubMedGoogle Scholar
• 154 Corner J, Plant H, AʼHern R. et al. Non-pharmacological intervention for breathlessness in lung cancer. Palliat Med 1996; 10: 299-305
  CrossrefPubMedGoogle Scholar
• 155 Filshie J, Penn K, Ashley S. et al. Acupuncture for the relief of cancer-related breathlessness. Palliat Med 1996; 10: 145-150
  CrossrefPubMedGoogle Scholar
• 156 Leitlinien der DGP Sektion Pflege. Atemnot in der letzten Lebensphase. http://www.dgpalliativmedizin.de/pflege/pflegeleitlinien
  PubMedGoogle Scholar
• 157 Katsenos S, Charisis A, Daskalopoulos G. Long-term oxygen therapy in chronic obstructive pulmonary disease: the use of concentrators and liquid oxygen systems in north-western Greece. Respiration 2006; 73: 777-782
  CrossrefPubMedGoogle Scholar
• 158 McCoy RW. Options for home oxygen therapy equipment: storage and metering of oxygen in the home. Respir Care 2013; 58: 65-85
  CrossrefPubMedGoogle Scholar
• 159 Gould GA, Scott W, Hayhurst MD. et al. Technical and clinical assessment of oxygen concentrators. Thorax 1985; 40: 811-816
  CrossrefPubMedGoogle Scholar
• 160 Aguiar C, Davidson J, Carvalho AK. et al. Tubing length for long-term oxygen therapy. Respir Care 2015; 60: 179-182
  CrossrefPubMedGoogle Scholar
• 161 Kampelmacher MJ. Long-term oxygen therapy (LTOT) revisited: in defense of traditional LTOT systems. Rev Port Pneumol 2012; 18: 158-159
  CrossrefPubMedGoogle Scholar
• 162 Pesce LI, Bassi GN, Santovito A. Clinical usefulness of a new portable oxygen concentrator. Monaldi Arch Chest Dis 1994; 49: 444-446
  PubMedGoogle Scholar
• 163 Burioka N, Takano K, Hoshino E. et al. Clinical utility of a newly developed pressure swing adsorption-type oxygen concentrator with a membrane humidifier. Respiration 1997; 64: 268-272
  CrossrefPubMedGoogle Scholar
• 164 Hall LW, Kellagher RE, Fleet KJ. A portable oxygen generator. Anaesthesia 1986; 41: 516-518
  CrossrefPubMedGoogle Scholar
• 165 Johns DP, Rochford PD, Streeton JA. Evaluation of six oxygen concentrators. Thorax 1985; 40: 806-810
  CrossrefPubMedGoogle Scholar
• 166 www.sauerstoffliga.de
  PubMed
• 167 Melani AS, Sestini P, Rottoli P. Home oxygen therapy: re-thinking the role of devices. Expert Rev Clin Pharmacol 2018; 11: 279-289
  CrossrefPubMedGoogle Scholar
• 168 Lee GJ, Oh YM, Oh SK. et al. Synchronization of oxygen delivery with breathing pattern for enhanced comfort: a bench study. Respir Care 2013; 58: 498-506
  CrossrefPubMedGoogle Scholar
• 169 Chen JZ, Katz IM, Pichelin M. et al. Comparison of pulsed versus continuous oxygen delivery using realistic adult nasal airway replicas. Int J Chron Obstruct Pulmon Dis 2017; 12: 2559-2571
  CrossrefPubMedGoogle Scholar
• 170 Palwai A, Skowronski M, Coreno A. et al. Critical comparisons of the clinical performance of oxygen-conserving devices. Am J Respir Crit Care Med 2010; 181: 1061-1071
  CrossrefPubMedGoogle Scholar
• 171 Nasilowski J, Przybylowski T, Zielinski J. et al. Comparing supplementary oxygen benefits from a portable oxygen concentrator and a liquid oxygen portable device during a walk test in COPD patients on long-term oxygen therapy. Respir Med 2008; 102: 1021-1025
  CrossrefPubMedGoogle Scholar
• 172 Mussa CC, Tonyan L, Chen YF. et al. Perceived Satisfaction With Long-Term Oxygen Delivery Devices Affects Perceived Mobility and Quality of Life of Oxygen-Dependent Individuals With COPD. Respir Care 2018; 63: 11-19
  CrossrefPubMedGoogle Scholar
• 173 AlMutairi HJ, Mussa CC, Lambert CT. et al. Perspectives from COPD Subjects on Portable Long-Term Oxygen Therapy Devices. Respir Care 2018; 63: 1321-1330
  CrossrefPubMedGoogle Scholar
• 174 Gloeckl R, Osadnik C, Bies L. et al. Comparison of continuous flow versus demand oxygen delivery systems in patients with COPD: A systematic review and meta-analysis. Respirology 2019; 24: 329-337
  CrossrefPubMedGoogle Scholar
• 175 Gloeckl R, Jarosch I, Schneeberger T. et al. Comparison of supplemental oxygen delivery by continuous versus demand based flow systems in hypoxemic COPD patients – A randomized, single-blinded cross-over study. Respir Med 2019; 156: 26-32
  CrossrefPubMedGoogle Scholar
• 176 Khor YH, McDonald CF, Hazard A. et al. Portable oxygen concentrators versus oxygen cylinder during walking in interstitial lung disease: A randomized crossover trial. Respirology 2017; 22: 1598-1603
  CrossrefPubMedGoogle Scholar
• 177 Franchini ML, Athanazio R, Amato-Lourenço LF. et al. Oxygen With Cold Bubble Humidification Is No Better Than Dry Oxygen in Preventing Mucus Dehydration, Decreased Mucociliary Clearance, and Decline in Pulmonary Function. Chest 2016; 150: 407-414
  CrossrefPubMedGoogle Scholar
• 178 Tausendpfund C, Petro W. Long-term oxygen therapy: which form of administration can be recommended?. Pneumologie 1996; 50: 260-267
  PubMedGoogle Scholar
• 179 Köhler D, Knoch M, Sommerfeld C. et al. A new oxygen applicator for simultaneous mouth and nose breathing. Chest 1993; 103: 1157-1160
  CrossrefPubMedGoogle Scholar
• 180 Christopher KL, Schwartz MD. Transtracheal oxygen therapy. Chest 2011; 139: 435-440
  CrossrefPubMedGoogle Scholar
• 181 Kampelmacher MJ, Deenstra M, van Kesteren RG. et al. Transtracheal oxygen therapy: an effective and safe alternative to nasal oxygen administration. Eur Respir J 1997; 10: 828-833
  CrossrefPubMedGoogle Scholar
• 182 Roberts CM, Bell J, Wedzicha JA. Comparison of the efficacy of a demand oxygen delivery system with continuous low flow oxygen in subjects with stable COPD and severe oxygen desaturation on walking. Thorax 1996; 51: 831-834
  CrossrefPubMedGoogle Scholar
• 183 Martí S, Pajares V, Morante F. et al. Are oxygen-conserving devices effective for correcting exercise hypoxemia?. Respir Care 2013; 58: 1606-1613
  CrossrefPubMedGoogle Scholar
• 184 Chatburn RL, Lewarski JS, McCoy RW. Nocturnal oxygenation using a pulsed-dose oxygen-conserving device compared to continuous flow. Respir Care 2006; 51: 252-256
  PubMedGoogle Scholar
• 185 OʼDriscoll BR, Howard LS, Davison AG. BTS guideline for emergency oxygen use in adult patients. Thorax 2008; 63: vi1-68
  PubMedGoogle Scholar
• 186 Leggett RJ, Flenley DC. Portable oxygen and exercise tolerance in patients with chronic hypoxic cor pulmonale. Br Med J 1977; 2: 84-86
  CrossrefPubMedGoogle Scholar
• 187 Peckham DG, McGibbon K, Tonkinson J. et al. Improvement in patient compliance with long-term oxygen therapy following formal assessment with training. Respir Med 1998; 92: 1203-1206
  CrossrefPubMedGoogle Scholar
• 188 Pépin JL, Barjhoux CE, Deschaux C. ANTADIR Working Group on Oxygen Therapy. Association Nationale de Traitement à Domicile des Insuffisants Respiratories. et al. Long-term oxygen therapy at home. Compliance with medical prescription and effective use of therapy. Chest 1996; 109: 1144-1150
  CrossrefPubMedGoogle Scholar
• 189 Lacasse Y, LaForge J, Maltais F. Got a match? Home oxygen therapy in current smokers. Thorax 2006; 61: 374-375
  CrossrefPubMedGoogle Scholar
• 190 Andreas S, Batra A, Behr J. et al. Smoking cessation in patients with COPD. Pneumologie 2014; 68: 237-258
  Article in Thieme ConnectPubMedGoogle Scholar
• 191 Amani H, Lozano DD, Blome-Eberwein S. Brother, have you got a light? Assessing the need for intubation in patients sustaining burn injury secondary to home oxygen therapy. J Burn Care Res 2012; 33: e280-e285
  CrossrefPubMedGoogle Scholar
• 192 Galligan CJ, Markkanen PK, Fantasia LM. et al. A growing fire hazard concern in communities: home oxygen therapy and continued smoking habits. New Solut 2015; 24: 535-554
  CrossrefPubMedGoogle Scholar
• 193 Tanash HA, Huss F, Ekström M. The risk of burn injury during long-term oxygen therapy: a 17-year longitudinal national study in Sweden. Int J Chron Obstruct Pulmon Dis 2015; 10: 2479-2484
  CrossrefPubMedGoogle Scholar
• 194 Tanash HA, Ringbaek T, Huss F. et al. Burn injury during long-term oxygen therapy in Denmark and Sweden: the potential role of smoking. Int J Chron Obstruct Pulmon Dis 2017; 12: 193-197
  CrossrefPubMedGoogle Scholar
• 195 www.europeanlung.org
  PubMed
• 196 www.melonet.de
  PubMed
• 197 Shrikrishna D, Coker RK. Managing passengers with stable respiratory disease planning air travel: British Thoracic Society recommendations. Thorax 2011; 66: 831-833
  CrossrefPubMedGoogle Scholar
• 198 Dillard TA, Berg BW, Rajagopal KR. et al. Hypoxemia during air travel in patients with chronic obstructive pulmonary disease. Ann Intern Med 1989; 111: 362-367
  CrossrefPubMedGoogle Scholar
• 199 www.g-ba.de
  PubMed