Original ResearchFull Report: Clinical—LiverAccuracy of FibroScan Controlled Attenuation Parameter and Liver Stiffness Measurement in Assessing Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease
Full Report: Clinical—Liver
Graphical abstract
Keywords
VCTE
NASH
Noninvasive
Biomarker
Abbreviations used in this paper
ALT
alanine transaminase
AUC
area under the curve
AUROC
area under the receiver operating characteristic curve
BMI
body mass index
CAP
controlled attenuation parameter
CI
confidence interval
CRN
clinical research network
IQR
interquartile range
LB
liver biopsy
LSM
liver stiffness measurement
NAFL
nonalcoholic fatty liver
NAFLD
nonalcoholic fatty liver disease
NASH
nonalcoholic steatohepatitis
NFS
NAFLD fibrosis score
NPV
negative predictive value
PPV
positive predictive value
Se
sensitivity
STARD
standards for reporting of diagnostic accuracy studies
ULN
upper limit of normal
VCTE
vibration-controlled transient elastography
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Conflicts of interest The authors disclose no conflicts.
Funding This work was funded by Echosens, the sponsors of this study. Peter J. Eddowes, Jon Deeks, and Philip N. Newsome were supported by the National Institute of Health Research (NIHR) Birmingham Biomedical Research Centre (BRC). Jeremy F. Cobbold was supported by the NIHR Oxford BRC. Indra N. Guha was supported by NIHR Nottingham BRC. This study/project is supported by the National Institute for Health Research Birmingham Biomedical Research Centre (Grant Reference Number BRC-1215-20009). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.
© 2019 by the AGA Institute