Original ResearchFull Report: Basic and Translational—PancreasCathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice
Full Report: Basic and Translational—Pancreas
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Graphical abstract
Keywords
Pancreatic Inflammation
Mechanisms
Immune Response
Mouse Model
Abbreviations used in this paper
ATP
adenosine triphosphate
BMDM
bone marrow-derived macrophages
CCK
cholecystokinin
CTSB
cathepsin B
CTSL
cathepsin L
DAMP
damage-associated molecular pattern
IL
interleukin
LPS
lipopolysaccharide
MCP-1
monocyte chemoattractant protein-1
NKκBp65
nuclear factor κB p65
NLRP3
nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3
TNFα
tumor necrosis factor α
WT
wild-type
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Conflict of interest The authors disclose no conflicts.
Funding The Deutsche Forschungsgemeinschaft (DFG MA 4115/1-2/3, DFG SE 2702/2-1, GRK 1947;A3), the Federal Ministry of Education and Research (BMBF GANI-MED 03IS2061A and BMBF 0314107, 01ZZ9603, 01ZZ0103, 01ZZ0403, 03ZIK012), and the European Union (EU-FP-7: EPC-TM), V-630-S-150-2012/132/133 and ESF/14-BM-A55-0045/16.
Author names in bold designate shared co-first authorship.
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Authors share co-senior authorship.
© 2018 by the AGA Institute. Published by Elsevier Inc.