Original ResearchFull Report: Clinical—Alimentary TractIn Functional Dyspepsia, Hypersensitivity to Postprandial Distention Correlates With Meal-Related Symptom Severity
Section snippets
Study Subjects
Healthy volunteers were recruited for the study through advertisement at Leuven University Hospital. None of the healthy subjects had symptoms or a history of gastrointestinal disease or drug allergies and were not taking any medication. Patients with FD presented to the outpatient clinic because of unexplained dyspeptic symptoms and underwent careful history taking and clinical examination, upper gastrointestinal endoscopy, routine biochemistry, and upper abdominal ultrasonography. All
Characteristics of Patients With FD-PDS
Twenty healthy volunteers (11 women; mean age, 24.4 ± 0.9 years) and 62 patients with FD (54 women; mean age, 41.7 ± 1.2 years) participated in this study. Patients were significantly older than healthy volunteers, and a higher proportion of the patients were female (P < 0.01). All patients fulfilled the Rome III criteria for FD-PDS, and 45 also had overlapping epigastric pain syndrome.1 Postprandial fullness and bloating were the most prevalent symptoms, present in 90% and 89% of patients,
Discussion
Visceral hypersensitivity has been considered a unifying pathophysiological mechanism that may underlie several functional gastrointestinal disorders by allowing physiological stimuli to induce symptoms.7, 8 Several studies have clearly established that, as a group, patients with FD have increased sensitivity to gastric distention.5, 9, 22, 23, 24 However, published studies have used different approaches to calculate sensitivity to gastric distention and to determine the range of normality. A
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Conflicts of interest The authors disclose no conflicts.
Funding Supported by a Methusalem grant from Leuven University (to J.T.) and by FWO grants (to J.T., R.F., H.V., T.V., and L.V.O.).