Clinical—Alimentary TractA National Study of Helicobactor pylori Infection in Gastric Biopsy Specimens
Section snippets
Data Source
The present study was conducted at Caris Life Sciences, a specialized gastrointestinal laboratory, operating in private outpatient endoscopy centers distributed throughout the United States. The results of all surgical pathology were stored in a single electronic database. Besides demographic characteristics, each patient record also contained the clinical and endoscopic diagnoses, as well as a detailed list of all results of surgical pathology. Surgical pathology diagnoses were coded in a
Results
The 4 panels of Figure 1 depict the age distributions associated with the 4 histologic diagnoses. The prevalence of H pylori and chronic active gastritis revealed similar age distributions, characterized by an initial rise between the ages 0 and 9 until 30–39 years and a subsequent plateau. In contrast, the prevalence of intestinal metaplasia showed a continuous age-dependent rise. Men and women had similar age distributions. Barrett's metaplasia rose in an age-dependent manner to peak at ages
Discussion
The present study was focused on the histoepidemiology of H pylori as evidenced by pathologic interpretations contained in a large database of gastric and esophageal biopsy specimens. Each diagnostic subgroup was populated by a large number of patients, which increased the statistical power of the analyses. The data were collected in a systematic fashion unbiased towards the aims of the present analysis. Using histologic findings to assess the underlying epidemiology represents a new way to
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This article has an accompanying continuing medical education activity on page e12. Learning Objective: Upon completion of this exercise, successful learners will gain a better understanding of the role of Helicobacter pylori in gastroesophageal reflux disease and Barrett's esophagus.
Conflicts of interests The authors disclose the following: Amnon Sonnenberg is supported by a grant from Takeda Pharmaceuticals. Richard H. Lash and Robert M. Genta are employed by Caris Life Sciences, Irving, Texas. Richard H. Lash is an officer and Richard H. Lash and Robert M. Genta are shareholders of Caris Life Sciences. The remaining authors disclose no conflicts.