Clinical Advances in Liver, Pancreas, and Biliary TractElevated Serum Alanine Aminotransferase and γ-Glutamyltransferase and Mortality in the United States Population
Section snippets
Methods
NHANES III was conducted in the United States from 1988 through 1994 by the National Center for Health Statistics (NCHS) of the Centers for Disease Control and Prevention (CDC).21 It consisted of interview, examination, and laboratory data collected from a complex multistage, stratified, clustered probability sample of the civilian, noninstitutionalized population aged 2 months and older, with oversampling of the elderly, non-Hispanic blacks, and Mexican Americans. The study was approved by the
ALT
The prevalence (±SE) of elevated ALT was 13.5% (±0.77%). Compared with participants with normal ALT, those with ALT elevation were younger and more likely to be Mexican American, obese, diabetic, lighter smokers, and less physically active, and to have a central fat distribution; higher total cholesterol, diastolic blood pressure, serum transferrin saturation, and prevalence of elevated C-reactive protein; and a lower HDL cholesterol and caffeine intake, but did not differ significantly with
Discussion
For ALT, the key finding of this study was the lack of an association with overall or CVD mortality in a large, national, population-based, prospective study. This was a consistent finding in both age-adjusted and multivariate-adjusted analyses. Few studies have performed similar analyses, and their results have been inconsistent and not comparable to those of the current study. A large Korean study found a strong association of all-cause mortality with ALT in men, but not women. It did not
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Supported by a contract from the National Institute of Diabetes and Digestive and Kidney Diseases (HHSN267200700001G).
The authors disclose no conflicts.