Clinical-liver, pancreas, and biliary tractCancer risk in patients with hereditary hemochromatosis and in their first-degree relatives☆
Section snippets
Patients
The cohort of patients with HH was assembled from 3 sources (Figure 1).
- 1.
In Sweden, virtually all inpatient care is public and referral to the hospital is based on county of residence rather than socioeconomic factors. The population-based Swedish Inpatient Register contains information on all inpatient care since 1964 (nationwide since 1987). About 99% of all hospitalizations are included.25 In this register, all individuals older than 15 years and discharged with a diagnosis of HH (coded
Patients
In total, 1847 patients were followed up for 12,398 person-years. During follow-up, 190 cancers were registered, corresponding to an SIR of 1.7 (95% CI, 1.5–2.0; Table 2). The relative risks for selected gastrointestinal cancers (cancers of the esophagus [SIR, 0; 95% CI, 0.0–3.2; n = 0), stomach [SIR, 0.3; 95% CI, 0.0–1.5; n = 1], pancreas [SIR, 1.0; 95% CI, 0.2–3.0; n = 3], and colon-rectum [SIR, 1.3; 95% CI, 0.7–2.0; n = 17]) and for the combined group of nonhepatobiliary cancers were not
Discussion
In this study, the hitherto largest population-based follow-up study of patients with HH and their first-degree relatives, we confirm the existence of an elevated risk of primary liver (hepatocellular) cancer among patients with HH. Among the first-degree relatives, we observed only a marginally increased and historic occurrence of liver cancer, the histopathologic spectrum of which differed from that of the patients. Furthermore, our study provided little support for the proposed increased
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2023, Comprehensive Guide to Hepatitis AdvancesPuzzling out iron complications in cancer drug resistance
2022, Critical Reviews in Oncology/HematologyCitation Excerpt :Likewise, in the patients with hereditary hemochromatosis, derived from homozygous mutations in the HFE gene, iron retention occurred in several organs, had increased the risk of cancer due to the induction of oxidative damage. ( Elmberg et al., 2003; Fargion et al., 2010; Forciniti et al., 2020). These observations imply the role of iron overload in the promotion of tumor growth (Beguin et al., 2014).
Iron
2021, Handbook on the Toxicology of Metals: Fifth Edition
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Supported by grant 00 1247 from the Swedish Cancer Society.