Original InvestigationDialysisMortality of Dialysis Patients According to Influenza and Pneumococcal Vaccination Status
Section snippets
Methods
The patient population for this study included hemodialysis and peritoneal dialysis patients in ESRD Networks 6 (North Carolina, South Carolina, and Georgia), 11 (Michigan, Minnesota, North Dakota, South Dakota, and Wisconsin), and 15 (Arizona, Colorado, Nevada, New Mexico, Utah, and Wyoming). These 3 Networks, which serve more than 65,000 patients in 1,033 dialysis facilities, collected the data used here as part of an ad hoc working group, the Safe and Timely Immunization Coalition (STIC).
Results
Of patients who had been receiving dialysis since at least January 1, 2005, a total of 41.8% were vaccinated against influenza during the 2005-2006 season and also had been vaccinated against pneumococcal disease. Compared with patients who had received neither vaccine, dual recipients were significantly less likely to be black (37.9% vs 57.6%), older on average, and more likely to receive hemodialysis (rather than peritoneal dialysis; Table 1). They also had generally worse baseline health
Discussion
Infection-related complications carry a high burden in this population.5, 6 Patients with ESRD—especially hemodialysis patients—are more likely than other patients to be hospitalized for bacteremia or septicemia (102.0 admissions/1,000 patient-years) and pneumonia (73.4 admissions/1,000 patient-years), and when hospitalized, these patients have lower 6-month survival rates.1, 7 The issue of influenza/pneumonia and mortality in this population extends beyond the assignment of a primary cause of
Acknowledgements
Support: The analyses upon which this publication is based were performed under contract HHSM-500-2006-NW006C entitled ESRD Networks Organization for the states of North Carolina, South Carolina, and Georgia, sponsored by the CMS, Department of Health and Human Services (DHHS). The content of this publication does not necessarily reflect the views or policies of the DHHS, nor does mention of trade names, commercial products, or organizations imply endorsement by the US. Government. This article
References (17)
- et al.
Infectious complications in chronic kidney disease
Adv Chronic Kidney Dis
(2006) - et al.
The use of vaccines in adult patients with renal disease
Am J Kidney Dis
(2005) Herd protection against influenza
J Clin Virol
(2006)- et al.
Influenza vaccine delivery and effectiveness in end-stage renal disease
Kidney Int
(2003) - et al.
New strategies are needed to improve the accuracy of influenza vaccine effectiveness estimates among seniors
J Clin Epidemiol
(2009) - et al.
Influenza vaccination and risk of community-acquired pneumonia in immunocompetent elderly people: a population-based, nested case-control study
Lancet
(2008) - et al.
Comparison of causes of death using HEMO Study and HCFA end-stage renal disease death notification classification systemsThe National Institutes of Health-funded Hemodialysis. Health Care Financing Administration
Am J Kidney Dis
(2002) A single-center review of the death notification form: discontinuing dialysis before death is not a surrogate for withdrawal from dialysis
Am J Kidney Dis
(2002)
Cited by (57)
Factors Associated With Non-vaccination for Influenza Among Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
2024, American Journal of Kidney DiseasesEffectiveness and safety of pneumococcal vaccines used alone or combined with influenza vaccination in dialysis patients: A systematic review and meta-analysis
2020, VaccineCitation Excerpt :Risks of bias assessment of included studies were shown in Table 1 and Supplementary Table 2. The quality of the included observational studies was moderate to high according to the NOS criteria (three studies with high quality [15,16,19] and three studies with moderate quality [17,18,20]). The common issues identified included lack of representativeness of the exposed cohort [17–20], no description on variables considered in analysis [17,18,20] and short duration of follow-up [15,18].
Effects of influenza vaccination on the risk of cardiovascular and respiratory diseases and all-cause mortality
2020, Ageing Research Reviews
Originally published online June 13, 2012.
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Current affiliation: DaVita Clinical Research, Minneapolis, MN.