Original InvestigationDialysisNew-Onset Hyperglycemia in Nondiabetic Chinese Patients Started on Peritoneal Dialysis
Section snippets
Patient Selection
We studied 405 unselected Chinese patients newly started on continuous ambulatory PD in the dialysis unit of a single university hospital in Hong Kong from 1998 to 2004. Baseline data, including age, sex, underlying renal disease, previous fasting blood test, and PD regimen, were recorded. Comorbid conditions, including coronary artery disease, heart failure, peripheral vascular disease, cerebrovascular disease, dementia, chronic pulmonary disease, connective tissue disorder, peptic ulcer
Prevalence of New-Onset Hyperglycemia
We studied 405 patients. There were 136 patients with underlying diabetic nephropathy, and another 17 patients had preexisting diabetes before starting PD therapy. One of these patients had type 1, whereas all the others had type 2 diabetes. Average duration of diabetes before dialysis therapy was 9.5 ± 4.9 years. Thirty-five patients (22.9%) had symptomatic diabetic neuropathy at the initiation of dialysis therapy, 79 (51.6%) had documented retinopathy, and 59 (38.6%) had a history of laser
Discussion
In the present series, we find that fasting plasma glucose levels were greater than 200 mg/dL (>11.1 mmol/L) in 4.4% of PD patients without diabetes. The prevalence was remarkably similar to that of de novo diabetes reported in the published literature.9, 10 However, another 19% of our patients had a fasting plasma glucose level of 126 to 200 mg/dL (7.0 to 11.1 mmol/L). Our finding indicates that a milder degree of hyperglycemia is not uncommon in PD patients. In comparison, a previous study
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Originally published online as doi:10.1053/j.ajkd.2007.01.018 on March 1, 2007.
Support: CUHK research account 6901031. Potential conflicts of interest: None.