Original contributionGalectin-3 expression in various thyroid neoplasms and its possible role in metastasis formation*
References (39)
- et al.
Galectins: Structure and function of a large family of animal lectins
J Biol Chem
(1994) - et al.
Galectins: A family of animal beta-galactoside-binding lectins
Cell
(1994) - et al.
Structure of the mucine Mac-2 gene: Splice variants encode proteins lacking functional signal peptides
J Biol Chem
(1993) - et al.
Regulation of secretion and surface expression of Mac-2, a galactoside-binding protein of macrophages
J Biol Chem
(1994) - et al.
Changes in the distribution pattern of galectin-I and galectin-3 in human placenta correlates with the differentiation pathway of trophoblasts
Placenta
(1997) - et al.
Lactose-binding lectin expression in human colorectal carcinomas: Relation to tumor progression
Carbohydrate Res
(1991) - et al.
Differential expression of galectin-3 and galectin-1 in colorectal cancer progression
Gastroenterology
(1997) - et al.
Protein measurement with Folin phenol reagent
J Biol Chem
(1951) - et al.
Metastasis of human colon cancer is altered by modifying expression of the beta-galactose-binding protein galectin-3
Gastroenterology
(1998) - et al.
Inverse expression of two laminin binding proteins, 67LR and galectin-3, correlates with the invasive phenotype of trophoblastic tissue
Biochem Biophys Res Commun
(1994)
Galectins: A family of animal lectins that decipher glycocodes
J Biochem Tokyo
Purification of galectin-3 from ovine placenta: Developmentally regulated expression and immunological relevance
Glycobiology
Differential expression of galectin-1 and galectin-3 during first trimester human embryogenesis
Dev Dyn
Galectin-3 expression and effects on cyst enlargement and tubulogenesis in kidney epithelial MDCK cells cultured in three-dimensional matrices invitro
J Cell Sci
Increased content of an endogenous lactose-binding lectin in human colorectal carcinoma progressed to metastatic stages
Cancer Res
Carcinoembryonic antigen and other glycoconjugates act as ligands for galectin-3 in human colon carcinoma cells
Cancer Res
Colon cancer mutin: A new ligand for the beta-galactoside-binding protein galectin-3
Cancer Res
Expression of Lamp-1 and Lamp-2 and their interactions with galectin-3 in human tumor cells
Int J Cancer
Adhesion of human breast carcinoma to extracellular matrix proteins is modulated by galectin-3
Invas Metastas
Cited by (115)
The expression profiles of the galectin gene family in colorectal adenocarcinomas
2016, Human PathologyCitation Excerpt :This association can be related with the cell migration properties of galectin-3 in the early stages of colorectal cancer development. In addition, it has been suggested that the decreased galectin-3 may loosen the connection of cancer cells with the extracellular matrix to facilitate the invasive and metastatic properties of cancers [22]. A similar effect can be attributed to the expression and correlations between galectin-4, 7, 8, and 10 mRNAs, which showed slightly increased levels of their mRNA expression in colorectal carcinomas without any lymph node or distant metastasis.
Molecular regulation of galectin-expression and therapeutic implication in cancer progression
2016, Biomedicine and PharmacotherapyThe expression profiles of the galectin gene family in primary and metastatic papillary thyroid carcinoma with particular emphasis on galectin-1 and galectin-3 expression
2014, Experimental and Molecular PathologyCitation Excerpt :Turkoz and colleagues debated these findings, where the authors demonstrated a lower expression of galectin-3 in lymphatic metastases and their primary carcinomas (Türköz et al., 2008). It has been suggested that the decreased galectin-3 may loosen the connection of cancer cells with the extracellular matrix to facilitate the invasive properties of cancers (Kawachi et al., 2000). The results presented here do not support this latter theory, rather suggesting that an increased level of galectin-3 expression may be facilitative for cancer metastasis where the protein may act to modulate cell growth and be involved in the regulation of apoptosis (Dumic et al., 2006; Newlaczyl and Yu, 2011).
Contrast-enhanced ultrasound combined targeted microbubbles for diagnosis of highly aggressive papillary thyroid carcinoma
2023, Frontiers in EndocrinologyThyroid, Parathyroid, and Adrenal Glands
2022, Handbook of Practical Immunohistochemistry: Frequently Asked Questions
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Supported in part by Grant-in-Aid 10042012 from the Ministry ofEducation, Science, Sports, and Culture, Japan.