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Selective Serotonin Reuptake Inhibitor (SSRI) Use during Pregnancy and Effects on the Fetus and Newborn: A Meta-Analysis

Journal of Perinatology volume 25, pages 595–604 (2005)Cite this article

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are frequently used to treat depression during pregnancy and the postpartum period. These drugs are capable of crossing the placenta and being transferred to the newborn during lactation. This report reviews the available information regarding the effects of SSRIs on the fetus and newborn; including long-term neurodevelopmental outcomes.

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Acknowledgements

This research was supported by the National Institute of Mental Health, MH065062 to DMV, CRN and NK; and MH068489 to DMV and CRN. We thank Robert Schumacher, MD for his helpful comments during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Neonatal-Perinatal Medicine (K.A.L., S.M.D., C.R.N.), University of Michigan, Ann Arbor, MI, USA

    Keri A Lattimore MD, Steven M Donn MD & Charles R Neal Jr. , MD, PhD

  2. Division of Pediatric Endocrinology (D.M.V.), University of Michigan, Ann Arbor, MI, USA

    Delia M Vazquez MD

  3. Child Health Evaluation and Research (CHEAR) Unit (A.R.K.), C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA

    Alex R Kemper MD, MPH, MS

  4. Psychiatry Department (D.M.V.), University of Michigan, Ann Arbor, MI, USA

    Delia M Vazquez MD

  5. Biostatistics Department (N.K.), Center of Human Growth and Development, University of Michigan, Ann Arbor, MI, USA

    Niko Kaciroti PhD

Authors
  1. Keri A Lattimore MD
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  2. Steven M Donn MD
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  4. Alex R Kemper MD, MPH, MS
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  5. Charles R Neal Jr. , MD, PhD
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  6. Delia M Vazquez MD
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Additional information

Charles R. Neal, Jr., MD, PhD is presently at the University of Hawaii John A. Burns School of Medicine.

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Lattimore, K., Donn, S., Kaciroti, N. et al. Selective Serotonin Reuptake Inhibitor (SSRI) Use during Pregnancy and Effects on the Fetus and Newborn: A Meta-Analysis. J Perinatol 25, 595–604 (2005). https://doi.org/10.1038/sj.jp.7211352

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