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A prospective study of dietary carbohydrate quantity and quality in relation to risk of ovulatory infertility

European Journal of Clinical Nutrition volume 63, pages 78–86 (2009)Cite this article

Abstract

Objective:

To evaluate whether the amount or quality of carbohydrate in diet is associated with ovulatory infertility.

Subjects and Methods:

In total, 18 555 married, premenopausal women without a history of infertility were followed as they attempted a pregnancy or became pregnant during an 8-year period. Diet was assessed two times during follow-up using a validated food-frequency questionnaire and prospectively related to the incidence of infertility due ovulatory disorder.

Results:

During follow-up, 438 women reported ovulatory infertility. Total carbohydrate intake and dietary glycemic load were positively related to ovulatory infertility in analyses adjusted for age, body mass index, smoking, parity, physical activity, recency of contraception, total energy intake, protein intake and other dietary variables. The multivariable-adjusted risk ratio (RR) (95% confidence interval (CI)) of ovulatory infertility comparing the highest-to-lowest quintile of total carbohydrate intake was 1.91 (1.27–3.02). The corresponding RR (95% CI) for dietary glycemic load was 1.92 (1.26–2.92). Dietary glycemic index was positively related to ovulatory infertility only among nulliparous women. Intakes of fiber from different sources were unrelated to ovulatory infertility risk.

Conclusions:

The amount and quality of carbohydrate in diet may be important determinants of ovulation and fertility in healthy women.

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Acknowledgements

Financial Support: The work reported in this article was supported by CA50385, the main Nurses' Health Study II grant, by the training Grant T32 DK-007703 and by the Yerby Postdoctoral Fellowship Program.

The Nurses Health Study II is supported for other specific projects by the following NIH Grants: CA55075, CA67262, AG/CA14742, CA67883, CA65725, DK52866, HL64108, HL03804.

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Authors and Affiliations

  1. Department of Nutrition, Harvard School of Public Health, Boston, MA, USA

    J E Chavarro & W C Willett

  2. Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

    J E Chavarro, J W Rich-Edwards, B A Rosner & W C Willett

  3. Division of Women's Health and Connors Center for Women's Health and Gender Biology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

    J W Rich-Edwards

  4. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA

    J W Rich-Edwards & W C Willett

  5. Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA

    B A Rosner

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  1. J E Chavarro
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Correspondence to J E Chavarro.

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Chavarro, J., Rich-Edwards, J., Rosner, B. et al. A prospective study of dietary carbohydrate quantity and quality in relation to risk of ovulatory infertility. Eur J Clin Nutr 63, 78–86 (2009). https://doi.org/10.1038/sj.ejcn.1602904

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