Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Catching the common cold

Nature Structural & Molecular Biology volume 11, pages 388–390 (2004)Cite this article

The structure of a minor group human rhinovirus in complex with a receptor fragment reveals how the ligand-binding repeats of LDL receptor family proteins bind to these viruses and also suggests a preferred mode for partner recognition by these repeats.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Structures of HRV–receptor complexes.
Figure 2: Virus-receptor and intramolecular LDL receptor interfaces.
Figure 3

Accession codes

Accessions

Protein Data Bank

References

  1. Greve, J.M. et al. Cell 56, 839–847 (1989).

    Article  CAS  Google Scholar 

  2. Staunton, D.E. et al. Cell 56, 849–853 (1989).

    Article  CAS  Google Scholar 

  3. Hofer, F. et al. Proc. Natl. Acad. Sci. USA 91, 1839–1842 (1994).

    Article  CAS  Google Scholar 

  4. Verdaguer, N., Fita, I., Reithmayer, M., Moser, R. & Blaas, D. Nat. Struct. Mol. Biol. 11, 429–434 (2004).

    Article  CAS  Google Scholar 

  5. Rossmann, M.G. et al. Nature 317, 145–153 (1985).

    Article  CAS  Google Scholar 

  6. Hogle, J.M., Chow, M. & Filman, D.J. Science 229, 1358–1365 (1985).

    Article  CAS  Google Scholar 

  7. Rossmann, M.G., He, Y. & Kuhn, R.J. Trends Microbiol. 10, 324–331 (2002).

    Article  CAS  Google Scholar 

  8. Kolatkar, P.R. et al. EMBO J. 18, 6249–6259 (1999).

    Article  CAS  Google Scholar 

  9. Hewat, E.A. et al. EMBO J. 19, 6317–6325 (2000).

    Article  CAS  Google Scholar 

  10. Herz, J., Gotthardt, M. & Willnow, T.E. Curr. Opin. Lipidol. 11, 161–166 (2000).

    Article  CAS  Google Scholar 

  11. Blacklow, S.C. & Kim, P.S. Nat. Struct. Biol. 3, 758–762 (1996).

    Article  CAS  Google Scholar 

  12. Fass, D., Blacklow, S., Kim, P.S. & Berger, J.M. Nature 388, 691–693 (1997).

    Article  CAS  Google Scholar 

  13. Vlasak, M., Blomqvist, S., Hovi, T., Hewat, E. & Blaas, D. J. Virol. 77, 6923–6930 (2003).

    Article  CAS  Google Scholar 

  14. Duechler, M., Ketter, S., Skern, T., Kuechler, E. & Blaas, D. J. Gen. Virol. 74, 2287–2291 (1993).

    Article  CAS  Google Scholar 

  15. Rudenko, G. et al. Science 298, 2353–2358 (2002).

    Article  CAS  Google Scholar 

  16. Snyers, L., Zwickl, H. & Blaas, D. J. Virol. 77, 5360–5369 (2003).

    Article  CAS  Google Scholar 

  17. Prchla, E., Kuechler, E., Blaas, D. & Fuchs, R. J. Virol. 68, 3713–3723 (1994).

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Baravalle, G., Brabec, M., Snyers, L., Blaas, D. & Fuchs, R. J. Virol. 78, 2729–2737 (2004).

    Article  CAS  Google Scholar 

  19. Brabec, M., Baravalle, G., Blaas, D. & Fuchs, R. J. Virol. 77, 5370–5377 (2003).

    Article  CAS  Google Scholar 

  20. Hewat, E.A., Neumann, E. & Blaas, D. Mol. Cell 10, 317–326 (2002).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

I am deeply indebted to D. Filman for back-calculation of the maps used to prepare Figure 1, and to both D. Filman and D. Bubeck for help with rendering the maps for the figure. I am also grateful to N. Verdaguer and colleagues for releasing their coordinates before publication. S.C.B. is supported by grants from the US National Institutes of Health (HL61001) and is a Pew Scholar in the Biomedical Sciences and an Established Investigator of the American Heart Association.

Author information

Authors and Affiliations

  1. Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, NRB 652D, 77 Avenue Louis Pasteur, Boston, 02115, Massachusetts, USA

    Stephen C Blacklow

Authors
  1. Stephen C Blacklow
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Blacklow, S. Catching the common cold. Nat Struct Mol Biol 11, 388–390 (2004). https://doi.org/10.1038/nsmb0504-388

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb0504-388

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing