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Sacral neuromodulation and alterations in brain activity — discussing discrepancies

Nature Reviews Urology volume 14, pages 697–698 (2017)Cite this article

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Sacral neuromodulation is used to treat refractory overactive bladder (OAB). Recent research has shown that changes in brain activity during sacral neuromodulation relate to its mechanism of action and that these changes vary with device settings. Much remains to be discovered about how sacral neuromodulation influences brain activity, but studies are now beginning to elucidate these effects.

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References

  1. Weissbart, S. J. et al. Specific changes in brain activity in women with overactive bladder after successful sacral neuromodulation with InterStim®: an FMRI study [abstract]. Neurourol. Urodyn. 36 (Suppl. 1), S142–S143 (2017).

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  2. Gill, B. C. et al. Real-time changes in brain activity during sacral neuromodulation for overactive bladder. J. Urol. http://dx.doi.org/10.1016/j.juro.2017.06.074 (2017).

  3. Blok, B. F. M., Groen, J., Bosch, J. L. H. R., Veltman, D. J. & Lammertsma, A. A. Different brain effects during chronic and acute sacral neuromodulation in urge incontinent patients with implanted neurostimulators. BJU Int. 98, 1238–1243 (2006).

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Authors and Affiliations

  1. Department of Urology, Glickman Urological and Kidney Institute, Mail Stop Q10-1, 9500 Euclid Avenue, Cleveland, 44195, Ohio, USA

    Bradley C. Gill & Howard B. Goldman

  2. Lerner College of Medicine, Education Institute, Mail Stop Q10-1, 9500 Euclid Avenue, Cleveland, 44195, Ohio, USA

    Bradley C. Gill & Howard B. Goldman

  3. Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Mail Stop Q10-1, 9500 Euclid Avenue, Cleveland, 44195, Ohio, USA

    Bradley C. Gill

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  1. Bradley C. Gill
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  2. Howard B. Goldman
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Correspondence to Howard B. Goldman.

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Competing interests

B.C.G. declares no competing interests. H.B.G. received research funding from Medtronic for the work described in this article. Additionally, H.B.G. serves as a consultant for Medtronic, Allergan, Axonics, Nuvectra, NewUro, and Cook.

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Gill, B., Goldman, H. Sacral neuromodulation and alterations in brain activity — discussing discrepancies. Nat Rev Urol 14, 697–698 (2017). https://doi.org/10.1038/nrurol.2017.188

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