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GERD

GERD and insomnia—first degree relatives or distant cousins?

Two population-based studies highlight the detrimental role of night-time GERD symptoms on sleep quality. The studies reinforce the observation that loss of sleep is associated with night-time GERD symptoms, and that sleep loss from GERD is associated with decreased work production, increased use of health-care resources, and an overall reduction in quality of life for patients.

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References

  1. Adachi, K. et al. Predominant nocturnal acid reflux in patients with Los Angeles grade C and D reflux esophagitis. J. Gastroenterol. Hepatol. 16, 1191–1196 (2001).

    Article  CAS  Google Scholar 

  2. Dickman, R. et al. Comparisons of the distribution of oesophageal acid exposure throughout the sleep period among the different gastro-oesophageal reflux disease groups. Aliment. Pharmacol. Ther. 26, 41–48 (2007).

    Article  CAS  Google Scholar 

  3. Lagergren, J., Bergstrom, R., Lindgren, A. & Nyren, O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N. Engl. J. Med. 340, 825–831 (1999).

    Article  CAS  Google Scholar 

  4. Fass, R., Quan, S. F., O'Connor, G. T., Ervin, A. & Iber, C. Predictors of heartburn during sleep in a large prospective cohort study. Chest 127, 1658–1666 (2005).

    Article  Google Scholar 

  5. Farup, C. et al. The impact of nocturnal symptoms associated with gastroesophageal reflux disease on health-related quality of life. Arch. Intern. Med. 161, 45–52 (2001).

    Article  CAS  Google Scholar 

  6. Shaker, R., Castell, D. O., Schoenfeld, P. S. & Spechler, S. J. Nighttime heartburn is an under-appreciated clinical problem that impacts sleep and daytime function: the results of a Gallup survey conducted on behalf of the American Gastroenterological Association. Am. J. Gastroenterol. 98, 1487–1493 (2003).

    Article  Google Scholar 

  7. Mody, R., Bolge, S. C., Kanna, H. & Fass, R. Effects of gastroesophageal reflux disease on sleep and outcomes. Clin. Gastroenterol. Hepatol. 7, 953–959 (2009).

    Article  Google Scholar 

  8. Jansson, C. et al. A population-based study showing an association between gastroesophageal reflux disease and sleep problems. Clin. Gastroenterol. Hepatol. 7, 960–965 (2009).

    Article  Google Scholar 

  9. Johnson, D. A. et al. Effect of esomeprazole on nighttime heartburn and sleep quality in patients with GERD: A randomized placebo-controlled trial. Am. J. Gastroenterol. 100, 1914–1922 (2005).

    Article  CAS  Google Scholar 

  10. Gagliardi, G. S. et al. The effect of zolpidem on the sleep arousal response to nocturnal acid exposure. Clin. Gastroenterol. Hepatol. 7, 948–952 (2009).

    Article  CAS  Google Scholar 

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Correspondence to Philip O. Katz.

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P.O. Katz is on the speakers bureau for AstraZeneca and Santarus. He is a consultant for AstraZeneca, Horizon Therapeutics, McNeil, Schering-Plough and Takeda, and an adjudicator for Eisai. E. Stein declares no competing interests.

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Stein, E., Katz, P. GERD and insomnia—first degree relatives or distant cousins?. Nat Rev Gastroenterol Hepatol 7, 8–10 (2010). https://doi.org/10.1038/nrgastro.2009.217

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