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Dabigatran etexilate

Nature Reviews Drug Discovery volume 7, pages 557–558 (2008)Cite this article

Abstract

Credit: Dabigatran etexilate

In March 2008, the European Commission granted marketing authorization for dabigatran etexilate (Pradaxa; Boehringer Ingelheim), a direct thrombin inhibitor, for the prevention of venous thromboembolic events in patients who have undergone total hip- or knee-replacement surgery.

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Figure 1: Anticoagulant drugs.

References

  1. Mackman, N. Triggers, targets and treatments for thrombosis. Nature 451, 914–918 (2008).

    Article  CAS  Google Scholar 

  2. Geerts, W. H. et al. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126, 338S–400S (2004).

    Article  CAS  Google Scholar 

  3. Di Nisio, M. et al. Direct thrombin inhibitors. N. Engl. J. Med. 353, 1028–1040 (2005).

    Article  CAS  Google Scholar 

  4. Hauel, N. H. et al. Structure-based design of novel potent nonpeptide thrombin inhibitors. J. Med. Chem. 45, 1757–1766 (2002).

    Article  CAS  Google Scholar 

  5. Wienen, W. et al. Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats. Thromb. Haemost. 98, 333–338 (2007).

    Article  CAS  Google Scholar 

  6. European Medicines Agency (EMEA). European Public Assessment Report — Pradaxa. EMEA web site [online], (2008).

  7. Eriksson, B. I. et al. Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. Thromb. Haemost. 5, 2178–2185 (2007).

    Article  CAS  Google Scholar 

  8. Eriksson, B. I. et al. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial. Lancet 370, 949–956 (2007).

    Article  CAS  Google Scholar 

  9. IMS, MIDAS Quantum (2007).

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Author information

Authors and Affiliations

  1. Bengt I. Eriksson is at the Department of Orthopaedic Surgery, Sahlgrenska University Hospital/Östra, SE-416 85 Gothenburg, Sweden. b.eriksson@orthop.gu.se,

    Bengt I. Eriksson

  2. Helen Smith and Uma Yasothan are at IMS Health, 7 Harewood Avenue, London NW1 6JB, UK. UYasothan@de.imshealth.com,

    Helen Smith & Uma Yasothan

  3. Peter Kirkpatrick is at Nature Reviews Drug Discovery. p.kirkpatrick@nature.com,

    Peter Kirkpatrick

Authors
  1. Bengt I. Eriksson
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  2. Helen Smith
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  3. Uma Yasothan
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  4. Peter Kirkpatrick
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Competing interests

B.I.E. has received consulting fees from Bayer Healthcare, Boehringer Ingelheim and Astellas.

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Eriksson, B., Smith, H., Yasothan, U. et al. Dabigatran etexilate. Nat Rev Drug Discov 7, 557–558 (2008). https://doi.org/10.1038/nrd2622

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