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Autism

A long genetic explanation

Nature volume 501, pages 36–37 (2013)Cite this article

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Topoisomerase enzymes facilitate gene transcription by resolving DNA tangles. Malfunction of these enzymes seems to compromise the expression of very long genes, potentially mediating neurodevelopmental disorders. See Article p.58

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Figure 1: Topoisomerase inhibitors and transcription.

Notes

  1. *This article and the paper under discussion1 were published online on 28 August 2013.

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Authors and Affiliations

  1. Robert N. Plasschaert and Marisa S. Bartolomei are in the Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.,

    Robert N. Plasschaert & Marisa S. Bartolomei

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  1. Robert N. Plasschaert
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  2. Marisa S. Bartolomei
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Correspondence to Marisa S. Bartolomei.

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Plasschaert, R., Bartolomei, M. A long genetic explanation. Nature 501, 36–37 (2013). https://doi.org/10.1038/nature12553

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