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Higher number of stem cells in the bone marrow of circulating low Igf-1 level Laron dwarf mice—novel view on Igf-1, stem cells and aging

Leukemia volume 25, pages 729–733 (2011)Cite this article

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Aging-associated changes in the nuclear architecture, chromatin structure, altered expression and activity of chromatin remodeling factors, and the change in pattern of epigenetic marks (DNA methylation and histone modification) affect all cells in the adult body, including the population of stem cells (SCs) that is responsible for proper tissue rejuvenation.1 The elucidation of these precise mechanisms will help to develop more efficient anti-aging strategies as well as facilitate a better understanding of age-related risks for cancer genesis.

Insulin-like growth factor-1 (Igf1), Insulin-like growth factor-2 (Igf2) and Insulin (Ins) are described as stimulators of proliferation of normal and malignant hematopoietic stem progenitor cells.2 Although Igf1 and Igf2 signal through tyrosine kinase receptor Igf1R, Ins together with Igf2 may activate classical insulin receptor and all factors together may activate a hybrid Igf1R/insulin receptor. In contrast, Igf2R serves as a ‘molecular bin’ that prevents Igf2 from binding to Igf1R or insulin receptor. Activation of Igf1R and insulin receptor depending on cell type affects cell metabolism and/or proliferation. Addition of these factors in clonogenic assays may enhance survival of human CD34+ hematopoietic stem progenitor cells and increase size of hematopoietic colonies, in particular, in erythroid lineage.2 However, Ins factors as reported may stimulate proliferation of leukemic blasts.

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Acknowledgements

This work was supported by NIH R01 DK074720, Stella and Henry Endowment and EU structural funds, Innovative Economy Operational Program POIG.01.01.01-00-109/09-01 and the Henry M and Stella M Hoenig Endowment to MZR, by NIH P20RR018733 from the National Center for Research Resources to MK, NIH P01 AG031736 to AB and NIH AG032290 to MM.

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Author notes

  1. J Ratajczak and D-M Shin: These authors contributed equally to this work.

Authors and Affiliations

  1. Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA

    J Ratajczak, D-M Shin, W Wan, R Liu, M Kucia & M Z Ratajczak

  2. Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, USA

    M M Masternak & A Bartke

  3. Department of Physiology, Pomeranian Medical University, Szczecin, Poland

    K Piotrowska & M Z Ratajczak

  4. Department of Histology and Embryology, Pomeranian Medical University, Szczecin, Poland

    B Wiszniewska

  5. Department of Physiology, Southern Illinois University School of Medicine, Springfield, IL, USA

    A Bartke

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  1. J Ratajczak
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Correspondence to M Z Ratajczak.

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Ratajczak, J., Shin, DM., Wan, W. et al. Higher number of stem cells in the bone marrow of circulating low Igf-1 level Laron dwarf mice—novel view on Igf-1, stem cells and aging. Leukemia 25, 729–733 (2011). https://doi.org/10.1038/leu.2010.314

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