Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Myeloma

International myeloma working group (IMWG) consensus statement and guidelines regarding the current status of stem cell collection and high-dose therapy for multiple myeloma and the role of plerixafor (AMD 3100)

Leukemia volume 23, pages 1904–1912 (2009)Cite this article

Abstract

Multiple myeloma is the most common indication for high-dose chemotherapy with autologous stem cell support (ASCT) in North America today. Stem cell procurement for ASCT has most commonly been performed with stem cell mobilization using colony-stimulating factors with or without prior chemotherapy. The target CD34+ cell dose to be collected as well as the number of apheresis performed varies throughout the country, but a minimum of 2 million CD34+ cells/kg has been traditionally used for the support of one cycle of high-dose therapy. With the advent of plerixafor (AMD3100) (a novel stem cell mobilization agent), it is pertinent to review the current status of stem cell mobilization for myeloma as well as the role of autologous stem cell transplantation in this disease. On June 1, 2008, a panel of experts was convened by the International Myeloma Foundation to address issues regarding stem cell mobilization and autologous transplantation in myeloma in the context of new therapies. The panel was asked to discuss a variety of issues regarding stem cell collection and transplantation in myeloma especially with the arrival of plerixafor. Herein, is a summary of their deliberations and conclusions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Pasquini MC, He V, Perez WS . CIBMTR summary slides part 1. CIBMTR Newsletter 2006; 12: 5–7.

    Google Scholar 

  2. Mavroudis D, Read E, Cottler-Fox M, Couriel D, Molldrem J, Carter C et al. CD34+ cell dose predicts survival, posttransplant morbidity, and rate of hematologic recovery after allogeneic marrow transplants for hematologic malignancies. Blood 1996; 88: 3223–3229.

    CAS  PubMed  Google Scholar 

  3. Bittencourt H, Rocha V, Chevret S, Socié G, Espérou H, Devergie A et al. Association of CD34 cell dose with hematopoietic recovery, infections, and other outcomes after HLA-identical sibling bone marrow transplantation. Blood 2002; 99: 2726–2733.

    Article  CAS  Google Scholar 

  4. Sierra J, Storer B, Hansen JA, Bjerke JW, Martin PJ, Petersdorf EW et al. Transplantation of marrow cells from unrelated donors for treatment of high-risk acute leukemia: the effect of leukemic burden, donor HLA-matching, and marrow cell dose. Blood 1997; 89: 4226–4235.

    CAS  PubMed  Google Scholar 

  5. Przepiorka D, Smith TL, Folloder J, Khouri I, Ueno NT, Mehra R et al. Risk factors for acute graft-versus-host disease after allogeneic blood stem cell transplantation. Blood 1999; 94: 1465–1470.

    CAS  PubMed  Google Scholar 

  6. Perez-Simon JA, Diez-Campelo M, Martino R, Sureda A, Caballero D, Canizo C et al. Impact of CD34+ cell dose on the outcome of patients undergoing reduced-intensity-conditioning allogeneic peripheral blood stem cell transplantation. Blood 2003; 102: 1108–1113.

    Article  CAS  Google Scholar 

  7. Zaucha R, Gooley T, Bensinger WI, Heimfeld S, Chauncey TR, Zaucha R et al. CD34 cell dose in granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cell grafts affects engraftment kinetics and development of extensive chronic graft-versus-host disease after human leukocyte antigen-identical sibling transplantation. Blood 2001; 98: 3221–3227.

    Article  CAS  Google Scholar 

  8. Mohty M, Bilger K, Jourdan E, Kuentz M, Michallet M, Bourhis JH et al. Higher doses of CD34+ peripheral blood stem cells are associated with increased mortality from chronic graft-versus-host disease after allogeneic HLA-identical sibling transplantation. Leukemia 2003; 17: 869–875.

    Article  CAS  Google Scholar 

  9. Desikan KR, Tricot G, Munshi NC, Annaissie E, Spoon D, Fassas A et al. Preceding chemotherapy, tumour load and age influence engraftment in multiple myeloma patients mobilized with granulocyte colony-stimulating factor alone. Br J Haematol 2001; 112: 242–247.

    Article  CAS  Google Scholar 

  10. Bensinger W, Appelbaum F, Rowley S, Storb R, Sanders J, Lilleby K et al. Factors that influence collection and engraftment of autologous peripheral blood-stem cells. J Clin Oncol 1995; 13: 2547–2555.

    Article  CAS  Google Scholar 

  11. Weaver CH, Hazelton B, Birch R, Palmer P, Allen C, Schwartzberg L et al. An analysis of engraftment kinetics as a function of the CD34 content of peripheral blood progenitor cell collections in 692 patients after the administration of myeloablative chemotherapy. Blood 1995; 86: 3961–3969.

    CAS  PubMed  Google Scholar 

  12. Benedetti G, Patoia L, Giglietti A, Alessio M, Pelicci P, Grignani F . Very large amounts of peripheral blood progenitor cell eliminate severe thrombocytopenia after high-dose melphalan in advanced breast cancer patients. Bone Marrow Transplant 1999; 24: 971–979.

    Article  CAS  Google Scholar 

  13. Ketterer N, Salles G, Raba M, Espinouse D, Sonet A, Tremisi P et al. High CD34+ cell counts decrease hematologic toxicity of autologous peripheral blood progenitor cell transplantation. Blood 1998; 91: 3148–3155.

    CAS  PubMed  Google Scholar 

  14. Oran B, Malek K, Sanchorawala V, Wright DG, Quillen K, Finn KT et al. Predictive factors for hematopoietic engraftment after autologous peripheral blood stem cell transplantation for AL amyloidosis. Bone Marrow Transplant 2005; 35: 567–575.

    Article  CAS  Google Scholar 

  15. Kim DH, Sohn SK, Jeon SB, Baek JH, Kim JG, Lee NY et al. Prognostic significance of platelet recovery pattern after allogeneic HLA-identical sibling transplantation and its association with severe acute GVHD. Bone Marrow Transplant 2006; 37: 101–108.

    Article  CAS  Google Scholar 

  16. Bruno B, Gooley T, Sullivan KM, Davis C, Bensinger WI, Storb R et al. Secondary failure of platelet recovery after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2001; 7: 154–162.

    Article  CAS  Google Scholar 

  17. Desikan KR, Barlogie B, Jagannath S, Vesole DH, Siegel D, Fassas A et al. Comparable engraftment kinetics following peripheral-blood stem-cell infusion mobilized with granulocyte colony-stimulating factor with or without cyclophosphamide in multiple myeloma. J Clin Oncol 1998; 16: 1547–1553.

    Article  CAS  Google Scholar 

  18. Alegre A, Tomás JF, Martínez-Chamorro C, Gil-Fernández JJ, Fernández-Villalta MJ, Arranz R et al. Comparison of peripheral blood progenitor cell mobilization in patients with multiple myeloma: high-dose cyclophosphamide plus GM-CSF vs G-CSF alone. Bone Marrow Transplant 1997; 20: 211–217.

    Article  CAS  Google Scholar 

  19. Demirer T, Ayli M, Ozcan M, Gunel N, Haznedar R, Dagli M et al. Mobilization of peripheral blood stem cells with chemotherapy and recombinant human granulocyte colony-stimulating factor (rhG-CSF): a randomized evaluation of different doses of rhG-CSF. Br J Haematol 2002; 116: 468–474.

    Article  CAS  Google Scholar 

  20. Arora M, Burns LJ, Barker JN, Miller JS, Defor TE, Olujohungbe AB et al. Randomized comparison of granulocyte colony-stimulating factor versus granulocyte-macrophage colony-stimulating factor plus intensive chemotherapy for peripheral blood stem cell mobilization and autologous transplantation in multiple myeloma. Biol Blood Marrow Transplant 2004; 10: 395–404.

    Article  CAS  Google Scholar 

  21. Gojo I, Guo C, Sarkodee-Adoo C, Meisenberg B, Fassas A, Rapoport AP et al. High-dose cyclophosphamide with or without etoposide for mobilization of peripheral blood progenitor cells in patients with multiple myeloma: efficacy and toxicity. Bone Marrow Transplant 2004; 34: 69–76.

    Article  CAS  Google Scholar 

  22. Dingli D, Nowakowski GS, Dispenzieri A, Lacy MQ, Hayman S, Litzow MR et al. Cyclophosphamide mobilization does not improve outcome in patients receiving stem cell transplantation for multiple myeloma. Clin Lymphoma Myeloma 2006; 6: 384–388.

    Article  CAS  Google Scholar 

  23. Lefrère F, Zohar S, Ghez D, Delarue R, Audat F, Suarez F et al. The VAD chemotherapy regimen plus a G-CSF dose of 10 microg/kg is as effective and less toxic than high-dose cyclophosphamide plus a G-CSF dose of 5 microg/kg for progenitor cell mobilization: results from a monocentric study of 82 patients. Bone Marrow Transplant 2006; 37: 725–729.

    Article  Google Scholar 

  24. Bruns I, Steidl U, Kronenwett R, Fenk R, Graef T, Rohr UP et al. A single dose of 6 or 12 mg of pegfilgrastim for peripheral blood progenitor cell mobilization results in similar yields of CD34+ progenitors in patients with multiple myeloma. Transfusion 2006; 46: 180–185.

    Article  CAS  Google Scholar 

  25. Barlogie B, Anaissie E, van Rhee F, Pineda-Roman M, Zangari M, Shaughnessy J et al. The Arkansas approach to therapy of patients with multiple myeloma. Best Pract Res Clin Haematol 2007; 20: 761–781.

    Article  CAS  Google Scholar 

  26. Hiwase DK, Bollard G, Hiwase S, Bailey M, Muirhead J, Schwarer AP . Intermediate-dose CY and G-CSF more efficiently mobilize adequate numbers of PBSC for tandem autologous PBSC transplantation compared with low-dose CY in patients with multiple myeloma. Cytotherapy 2007; 9: 539–547.

    Article  CAS  Google Scholar 

  27. Zappasodi P, Nosari AM, Astori C, Ciapanna D, Bonfichi M, Varettoni M et al. DCEP chemotherapy followed by a single, fixed dose of pegylated filgrastim allows adequate stem cell mobilization in multiple myeloma patients. Transfusion 2008; 48: 857–860.

    Article  CAS  Google Scholar 

  28. Pelus LM . Peripheral blood stem cell mobilization: new regimens, new cells, where do we stand. Curr Opin Hemato 2008; 15: 285–292.

    Article  Google Scholar 

  29. Perea G, Sureda A, Martino R, Altés A, Martínez C, Cabezudo E et al. Predictive factors for a successful mobilization of peripheral blood CD34+ cells in multiple myeloma. Ann Hematol 2001; 80: 592–597.

    Article  CAS  Google Scholar 

  30. de la Rubia J, Blade J, Lahuerta JJ, Ribera JM, Martínez R, Alegre A et al. Effect of chemotherapy with alkylating agents on the yield of CD34+ cells in patients with multiple myeloma. Results of the Spanish Myeloma Group (GEM) Study. Haematologica 2006; 91: 621–627.

    CAS  PubMed  Google Scholar 

  31. Kumar S, Dispenzieri A, Lacy MQ, Hayman SR, Fuadi SK, Gastineau DA et al. Impact of lenalidomide therapy on stem cell mobilization and engraftment post-peripheral blood stem cell transplantation in patients with newly diagnosed myeloma. Leukemia 2007; 21: 2035–2042.

    Article  CAS  Google Scholar 

  32. Mazumder A, Kaufman J, Niesvizky R, Lonial S, Vesole D, Jagannath S . Effect of lenalidomide therapy on mobilization of peripheral blood stem cells in previously untreated multiple myeloma patients. Leukemia 2007; 22: 1280–1281.

    Article  Google Scholar 

  33. Paripati H, Stewart AK, Cabou S, Dueck A, Zepeda VJ, Pirooz N et al. Compromised stem cell mobilization following induction therapy with lenalidomide in myeloma. Leukemia 2008; 22: 1282–1284.

    Article  CAS  Google Scholar 

  34. Mark T, Stern J, Furst J, Jayabalan D, Zafar F, LaRow A et al. Stem cell mobilization with cyclophosphamide overcomes the suppressive effect of lenalidomide therapy on stem cell collection in multiple myeloma. Biol Blood Marrow Transplant 2008; 14: 795–798.

    Article  CAS  Google Scholar 

  35. Tricot G, Jagannath S, Vesole D, Nelson J, Tindle S, Miller L et al. Peripheral blood stem cell transplants for multiple myeloma: identification of favorable variables for rapid engraftment in 225 patients. Blood 1995; 85: 588–596.

    CAS  PubMed  Google Scholar 

  36. Palumbo A, Bringhen S, Liberati AM, Caravita T, Falcone A, Callera V et al. Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized, controlled trial. Blood 2008; 112: 3107–3114.

    Article  CAS  Google Scholar 

  37. Mateos MV, Hernández JM, Hernández MT, Gutiérrez NC, Palomera L, Fuertes M et al. Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: updated time-to-events results and prognostic factors for time to progression. Haematologica 2008; 93: 560–565.

    Article  CAS  Google Scholar 

  38. Grignani G, Perissinotto E, Cavalloni G, Carnevale Schianca F, Aglietta M . Clinical use of AMD3100 to mobilize CD34+ cells in patients affected by non-Hodgkin's lymphoma or multiple myeloma. J Clin Oncol 2005; 23: 3871–3872.

    Article  Google Scholar 

  39. Flomenberg N, Devine SM, Dipersio JF, Liesveld JL, McCarty JM, Rowley SD et al. The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone. Blood 2005; 106: 1867–1874.

    Article  CAS  Google Scholar 

  40. Dipersio JF, Stadtmauer EA, Nademanee AP, Stiff P, Micallef I, Angell J et al. A phase III, multicenter, randomized, double-blind, placebo-controlled, comparative trial of AMD3100 (Perixafor) + G-CSF vs G-CSF + placebo for mobilization in multiple myeloma (MM) patients for autologous hematopoietic stem cell (aHSC) transplantation. Blood 2007; 110 abstract 445, 137a.

  41. Koreth J, Cutler CS, Djulbegovic B, Behl R, Schlossman RL, Munshi NC, Richardson PG et al. High-dose therapy with single autologous transplantation versus chemotherapy for newly diagnosed multiple myeloma: a systematic review and meta-analysis of randomized controlled trials. Biol Blood Marrow Transplant 2007; 3: 183–196.

    Article  Google Scholar 

  42. Attal M, Harousseau JL, Facon T, Guilhot F, Doyen C, Fuzibet JG et al. Single versus double autologous stem-cell transplantation for multiple myeloma. N Engl J Med 2003; 349: 2495–2502.

    Article  CAS  Google Scholar 

  43. Cavo M, Tosi P, Zamagni E, Cellini C, Tacchetti P, Patriarca F et al. Prospective, randomized study of single compared with double autologous stem-cell transplantation for multiple myeloma: Bologna 96 clinical study. J Clin Oncol 2007; 25: 2434–2441.

    Article  Google Scholar 

  44. Barlogie B, Tricot GJ, van Rhee F, Angtuaco E, Walker R, Epstein J et al. Long-term outcome results of the first tandem autotransplant trial for multiple myeloma. Br J Haematol 2006; 135: 158–164.

    Article  Google Scholar 

  45. Abdelkafi A, Ladeb S, Torjman L, Othman TB, Lakhal A, Romdhane NB et al. Single autologous stem-cell transplantation followed by maintenance therapy with thalidomide is superior to double autologous transplantation in multiple myeloma: results of a multicenter randomized clinical trial. Blood 2008; 111: 1805–1810.

    Article  Google Scholar 

  46. Mehta J, Tricot G, Jagannath S, Ayers D, Singhal S, Siegel D et al. Salvage autologous or allogeneic transplantation for multiple myeloma refractory to or relapsing after a first-line autograft. Bone Marrow Transplant 1998; 21: 887–892.

    Article  CAS  Google Scholar 

  47. Kumar A, Kharfan-Dabaja MA, Glasmacher A, Djulbegovic B . Tandem versus single autologous hematopoietic cell transplantation for the treatment of multiple myeloma: a systematic review and meta-analysis. J Natl Cancer Inst 2009; 21: 100–106.

    Article  Google Scholar 

  48. Mehta J, Singhal S . Current status of autologous hematopoietic stem cell transplantation in myeloma. Bone Marrow Transplant 2008; 42 (Suppl 1): S28–S34.

    Article  Google Scholar 

  49. Garban F, Attal M, Michallet M, Hulin C, Bourhis JH, Yakoub-Agha I et al. Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma. Blood 2006; 107: 3474–3480.

    Article  CAS  Google Scholar 

  50. Bruno B, Rotta M, Patriarca F, Mordini N, Allione B, Carnevale-Schianca F et al. A comparison of allografting with autografting for newly diagnosed myeloma. N Engl J Med 2007; 356: 1110–1120.

    Article  CAS  Google Scholar 

  51. Rosiñol L, Pérez-Simón JA, Sureda A, de la Rubia J, de Arriba F, Lahuerta JJ et al. A prospective PETHEMA study of tandem autologous transplantation versus autograft followed by reduced-intensity conditioning allogeneic transplantation in newly diagnosed multiple myeloma. Blood 2008; 112: 3591–3593.

    Article  Google Scholar 

  52. Schilling G, Hansen T, Shimoni A, Zabelina T, Pérez-Simón JA, Gutierrez NC et al. Impact of genetic abnormalities on survival after allogeneic hematopoietic stem cell transplantation in multiple myeloma. Leukemia 2008; 22: 1250–1255.

    Article  CAS  Google Scholar 

  53. Durie BGM, Harousseau JL, Miguel JS, Bladé J, Barlogie B, Anderson K et al. International uniform response criteria for multiple myeloma. Leukemia 2008; 20: 1467–1473.

    Article  Google Scholar 

Download references

Author information

Author notes

  1. S Giralt, E A Stadtmauer, J L Harousseau, A Palumbo, W Bensinger, R L Comenzo, S Kumar, N C Munshi, A Dispenzieri, R Kyle, G Merlini, J San Miguel, H Ludwig, R Hajek, S Jagannath, J Blade, S Lonial, M A Dimopoulos, H Einsele, B Barlogie, K C Anderson, M Gertz, M Attal, P Tosi, P Sonneveld, M Boccadoro, G Morgan, O Sezer, M V Mateos, M Cavo, D Joshua, I Turesson, W Chen, K Shimizu, R Powles, P G Richardson, R Niesvizky, S V Rajkumar and B G M Durie: See Appendix.

Authors and Affiliations

  1. Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    S Giralt

  2. Bone Marrow and Stem Cell Transplant Program, University of Pennsylvania Abramson Cancer Center, Philadelphia, PA, USA

    E A Stadtmauer

  3. Department of Hematology, Institute de Biologie, Nantes, France

    J L Harousseau

  4. Divisione di Ematologia dell Universita di Torino, Azienda Ospedaliera S. Giovanni Battista, Ospedale Molinette, Torino, Italy,

    A Palumbo & M Boccadoro

  5. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    W Bensinger

  6. Department of Clinical Laboratories, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    R L Comenzo

  7. Division of Hematology, Mayo Clinic, Rochester, MN, USA

    S Kumar, A Dispenzieri, R Kyle, M Gertz & S V Rajkumar

  8. Department of Medical Oncology, Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA, USA

    N C Munshi, K C Anderson & P G Richardson

  9. Department of Biochemistry, University Hospital San Matteo, Italy

    G Merlini

  10. Department of Hematology, Servicio de Hepatología, Hospital Universitario de Salamanca. CIC, IBMCC (USAL-CSIC), Spain

    J San Miguel & M V Mateos

  11. 1st Medical Department and Oncology, Wilhelminenspital Der Stat Wien, Vienna, Austria

    H Ludwig

  12. Czech Myeloma Group and Department of Internal Medicine Fn Brno and LF MM Brno, Czech Republic

    R Hajek

  13. Department of Medicine, Multiple Myeloma and Bone Marrow Stem Cell Transplant Program at St Vincent's Catholic Medical Center, New York, NY, USA

    S Jagannath

  14. Department of Hematology, Hospital Clinic, IDIBAPS, Barcelona, Spain

    J Blade

  15. Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA

    S Lonial

  16. Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece

    M A Dimopoulos

  17. Department of Internal Medicine, University of Wurzburg, Wurzburg, Germany

    H Einsele

  18. Departments of Hematology and Pathology, MIRT UAMS, Little Rock, AR, USA

    B Barlogie

  19. Departments of Hematology and Biostatistics, Purpan Hospital, Toulouse, France

    M Attal

  20. Institute of Hematology and Medical Oncology, University of Bologna, Bologna, Italy

    P Tosi

  21. Department of Hematology, Erasmus MC, Rotterdam, The Netherlands

    P Sonneveld

  22. Department of Hematology/Oncology, The Leukemia and Myeloma Program, Wimbledon, UK

    G Morgan

  23. Department of Hematology/Oncology, University of Berlin, Germany

    O Sezer

  24. Institute of Hematology and Medical Oncology Seragnoli, Bologna, Italy

    M Cavo

  25. Bosch Institute, University of Sydney, Royal Prince Alfred Hospital, New South Wales, Australia

    D Joshua

  26. Department of Hematology/Medicine Malmö University Hospital, Malm, ö, Sweden

    I Turesson

  27. Department of Hematology/ Oncology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

    W Chen

  28. Department of Internal Medicine, Nagoya City Midori General Hospital, Nagoya, Japan

    K Shimizu

  29. Department of Hematology/Oncology, Parkside Cancer Centre, London, UK

    R Powles

  30. Center for Lymphoma and Myeloma, Weill Medical College of Cornell University, New York, NY, USA

    R Niesvizky

  31. Aptium Oncology, Inc., Cedars-Sinai Outpatient Cancer Center at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA

    B G M Durie

Authors
  1. S Giralt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E A Stadtmauer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J L Harousseau
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A Palumbo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. W Bensinger
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R L Comenzo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. N C Munshi
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A Dispenzieri
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. R Kyle
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. G Merlini
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. J San Miguel
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. H Ludwig
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. R Hajek
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. S Jagannath
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. J Blade
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. S Lonial
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. M A Dimopoulos
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. H Einsele
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. B Barlogie
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. K C Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. M Gertz
    View author publications

    You can also search for this author in PubMed Google Scholar

  23. M Attal
    View author publications

    You can also search for this author in PubMed Google Scholar

  24. P Tosi
    View author publications

    You can also search for this author in PubMed Google Scholar

  25. P Sonneveld
    View author publications

    You can also search for this author in PubMed Google Scholar

  26. M Boccadoro
    View author publications

    You can also search for this author in PubMed Google Scholar

  27. G Morgan
    View author publications

    You can also search for this author in PubMed Google Scholar

  28. O Sezer
    View author publications

    You can also search for this author in PubMed Google Scholar

  29. M V Mateos
    View author publications

    You can also search for this author in PubMed Google Scholar

  30. M Cavo
    View author publications

    You can also search for this author in PubMed Google Scholar

  31. D Joshua
    View author publications

    You can also search for this author in PubMed Google Scholar

  32. I Turesson
    View author publications

    You can also search for this author in PubMed Google Scholar

  33. W Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  34. K Shimizu
    View author publications

    You can also search for this author in PubMed Google Scholar

  35. R Powles
    View author publications

    You can also search for this author in PubMed Google Scholar

  36. P G Richardson
    View author publications

    You can also search for this author in PubMed Google Scholar

  37. R Niesvizky
    View author publications

    You can also search for this author in PubMed Google Scholar

  38. S V Rajkumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  39. B G M Durie
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

on behalf of the IMWG

Corresponding author

Correspondence to S Giralt.

Appendix

Appendix

International Myeloma Working Group

Rafat Abonour, Indiana University School of Medicine, Indianapolis, IN, USA

Ray Alexanian, MD Anderson, Houston, TX, USA

Kenneth Anderson, DFCI, Boston, MA, USA

Michael Attal, Purpan Hospital, Toulouse, France

Herve Avet-Loiseau, Institute de Biologie, Nantes, France

Ashraf Badros, University of Maryland, Baltimore, MD, USA

Leif Bergsagel, Mayo Clinic Scottsdale, Scottsdale, AZ, USA

Joan Bladé, Hospital Clinica, Barcelona, Spain

Bart Barlogie, M.I.R.T. UAMS Little Rock, AR, USA

Regis Batille, Institute de Biologie, Nantes, France

Meral Beksac, Ankara University, Ankara, Turkey

Andrew Belch, Cross Cancer Institute, Alberta, Canada

Bill Bensinger, Fred Hutchinson Cancer Center, Seattle, WA, USA

Mario Boccadoro, University of Torino, Torino, Italy

Michele Cavo, Universita di Bologna, Bologna, Italy

Wen Ming Chen, MM Research Center of Beijing, Beijing, China

Tony Child, Leeds General Hospital, Leeds, United Kingdom

James Chim, Department of Medicine, Queen Mary Hospital, Hong Kong

Ray Comenzo, Memorial Sloane-Kettering, New York City, NY, USA

John Crowley, Cancer Research and Biostatistics, Seattle, WA, USA

William Dalton, H. Lee Moffitt, Tampa, FL, USA

Faith Davies, Royal Marsden Hospital, London, England

Cármino de Souza, Univeridade de Campinas, Caminas, Brazil

Michel Delforge, University Hospital Gasthuisberg, Leuven, Belgium

Meletios Dimopoulos, Alexandra Hospital, Athens, Greece

Angela Dispenzieri, Mayo Clinic, Rochester, MN, USA

Brian GM Durie, Cedars-Sinai Outpatient Cancer Center, Los Angeles, CA, USA

Hermann Einsele, Universitätsklinik Würzburg, Würzburg, Germany

Thierry Facon, Centre Hospitalier Regional Universitaire de Lille, Lille, France

Dorotea Fantl, Socieded Argentinade Hematolgia, Buenos Aires, Argentina

Jean-Paul Fermand, Hopitaux de Paris, Paris, France

Rafael Fonseca, Mayo Clinic Scottsdale, Scottsdale, AZ, USA

Gosta Gahrton, Karolinska Institute for Medicine, Huddinge, Sweden

Morie Gertz, Mayo Clinic, Rochester, MN, USA

John Gibson, Royal Prince Alfred Hospital, Sydney, Australia

Hartmut Goldschmidt, University Hospital Heidelberg, Heidelberg, Germany

Philip Greipp, Mayo Clinic, Rochester, MN, USA

Roman Hajek, Brno University, Brno, Czech Republic

Izhar Hardan, Tel Aviv University, Tel Aviv, Israel

Jean-Luc Harousseau, Institute de Biologie, Nantes, France

Hiroyuki Hata, Kumamoto University Hospital, Kumamoto, Japan

Yutaka Hattori, Keio University School of Medicine, Tokyo, Japan

Joy Ho, Royal Prince Alfred Hospital, Sydney, Australia

Vania Hungria, Clinica San Germano, Sao Paolo, Brazil

Shinsuke Ida, Nagoya City University Medical School, Nagoya, Japan

Peter Jacobs, Constantiaberg Medi-Clinic, Plumstead, South Africa

Sundar Jagannath, St Vincent's Comprehensive Cancer Center, New York, NY, USA

Hou Jian, Shanghai Chang Zheng Hospital, Shanghai, China

Douglas Joshua, Royal Prince Alfred Hospital, Sydney, Australia

Michio Kawano, Yamaguchi University, Ube, Japan

Nicolaus Kröger, University Hospital Hamburg, Hamburg, Germany

Shaji Kumar, Department of Hematology, Mayo Clinic, MN, USA

Robert Kyle, Department of Laboratory Med. and Pathology, Mayo Clinic, MN, USA

Juan Lahuerta, Grupo Espanol di Mieloma, Hospital Universitario, Madrid, Spain

Jae Hoon Lee, Gachon University Gil Hospital, Incheon, Korea

Xavier LeLeu, Hospital Huriez, CHRU Lille, France

Suzanne Lentzsch, UPMC Cancer Pavillion, Pittsburgh, PA, USA

Henk Lokhorst, University Medical Center Utrecht, Utrecht, The Netherlands

Sagar Lonial, Emory University School of Medicine, Atlanta, GA, USA

Heinz Ludwig, Wilhelminenspital Der Stat Wien, Vienna, Austria

Angelo Maiolino, Rua fonte da Saudade, Rio de Janeiro, Brazil

María-Victoria Mateos, University Hospital of Salamanca, Spain

Jayesh Mehta, Northwestern University, Chicago, IL, USA

GianPaolo Merlini, University of Pavia, Pavia, Italy

Joseph Mikhael, Mayo Clinic, Scottsdale, AZ, USA

Philippe Moreau, University Hospital, Nantes, France

Gareth Morgan, Royal Marsden Hospital, London, England

Nikhil Munshi, Diane Farber Cancer Institute, Boston, MA, USA

Yana Novis, Hospital SírioLibanês, Bela Vista, Brazil

Amara Nouel, Hospital Rutz y Paez, Bolivar, Venezuela

Robert Orlowski, MD Anderson, Houston, TX, USA

Antonio Palumbo, Cathedra Ematologia, Torino, Italy

Santiago Pavlovsky, Fundaleu, Buenos Aires, Argentina

Linda Pilarski, University of Alberta, Alberta, Canada

Raymond Powles, Leukaemia and Myeloma, Wimbledon, England

Ruben Niesvizky, Weill Medical College of Cornell University, New York, NY, USA

S Vincent Rajkumar, Mayo Clinic, Rochester, MN, USA

Donna Reece, Princess Margaret, Toronto, Canada

Tony Reiman, Cross Cancer Institute, Alberta, Canada

Paul Richardson, Dana Farber Cancer Institute, Boston, MA, USA

Angelina Rodriquez Morales, Bonco Metro Politano de Sangre, Caracas, Venezuela

Orhan Sezer, Department of Hem/Onc, Universitatsklinikum Charite, Berlin, Germany

John Shaughnessy, M.I.R.T. UAMS, Little Rock, AR, USA

Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan

David Siegel, Hackensack, Cancer Center, Hackensack, NJ, USA

Jesus San Miguel, University of Salamanca, Salamanca, Spain

Chaim Shustik, McGill, Toronto, Canada

Seema Singhal, Northwestern University, Chicago, IL, USA

Pieter Sonneveld, Erasmus MC, Rotterdam, The Netherlands

Andrew Spencer, The Alfred Hospital, Melbourne, Australia

Edward Stadtmauer, University of Pennsylvania, Philadelphia, PA, USA

Keith Stewart, Mayo Clinic Scottsdale, Scottsdale, AZ, USA

Patrizia Tosi, Italian Cooperative Group, Istituto di Ematologia Seragnoli, Bologna, Italy

Guido Tricot, Huntsman Cancer Institute, Salt Lake City, UT, USA

Ingemar Turesson, Department of Hematology, Malmo University, Malmo, Sweden

Brian Van Ness, University of Minnesota, Minneapolis, MN, USA

Ivan Van Riet, Brussels Vrija University, Brussels, Belgium

Robert Vescio, Cedars-Sinai Outpatient Cancer Center, Los Angeles, CA, USA

David Vesole, Loyola University Chicago, IL, USA

Anders Waage, University Hospital, Trondheim, Norway NSMG

Michael Wang, M.D. Anderson, Houston, TX, USA

Donna Weber, MD Anderson, Houston, TX, USA

Jan Westin, Sahlgrenska University Hospital, Gothenburg, Sweden

Keith Wheatley, University of Birmingham, Birmingham, United Kingdom

Dina B Yehuda, Department of Hematology, Hadassah University Hospital, Hadassah, Israel

Jeffrey Zonder, SWOG, Department of Hem/Onc, Karmanos Cancer Institute, MI, USA

Rights and permissions

Reprints and permissions

About this article

Cite this article

Giralt, S., Stadtmauer, E., Harousseau, J. et al. International myeloma working group (IMWG) consensus statement and guidelines regarding the current status of stem cell collection and high-dose therapy for multiple myeloma and the role of plerixafor (AMD 3100). Leukemia 23, 1904–1912 (2009). https://doi.org/10.1038/leu.2009.127

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2009.127

Keywords

This article is cited by

Search

Advanced search

Quick links