Elsevier

Kidney International

Volume 81, Issue 11, 1 June 2012, Pages 1116-1122
Kidney International

Original Article
Calcium balance in normal individuals and in patients with chronic kidney disease on low- and high-calcium diets

https://doi.org/10.1038/ki.2011.490Get rights and content
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Calcium balance in chronic kidney disease is poorly understood as calcium deficiency is a stimulus for secondary hyperparathyroidism and consequent bone loss while calcium excess promotes extraosseous calcifications. To help resolve this, we evaluated calcium balance in normal individuals and in patients with chronic kidney disease (CKD) on daily diets containing 800 and 2000 mg elemental calcium. Both normal individuals and patients with late stage 3 and stage 4 CKD were in slightly negative to neutral calcium balance on the 800-mg calcium diet. Normal individuals were in modest positive calcium balance on the 2000-mg diet, while patients with CKD on the same diet were in marked positive calcium balance at least over the 9 days of study; and significantly greater than the normal individuals. Increased calcium intake significantly decreased 1,25-dihydroxy-vitamin D and intact parathyroid hormone levels but did not alter the serum calcium concentration. Thus, our findings have important implications for both preventing calcium deficiency and loading in individuals with late stage 3 and stage 4 CKD.

Keywords

calcium
chronic kidney disease
mineral metabolism
parathyroid hormone
phosphate

Cited by (0)

DMS has received research funding from Amgen and Keryx Biopharmaceuticals, and has served on advisory boards and speakers' bureau for Amgen. Contents are the authors' sole responsibility and do not necessarily represent official National Institutes of Health views.