Abstract
In Borrelia hermsii, a spirochaete that causes relapsing fever, the switch between expression of two frequent variable major protein (VMP) types (7 and 21) is associated with a DNA rearrangement. Both cell types 7 and 21 contain untranscribed 7 and 21 VMP genes on linear plasmids. The serotype 7 cells contain an additional copy of the 7 VMP gene fused to an expression sequence on another linear plasmid. Switching to the 21 serotype involves removal of the transcribed 7 VMP gene and fusion of a copy of the 21 VMP gene to this same expression sequence. Thus recombination between linear plasmids can activate different VMP genes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Borst, P. Mobile Genetic Elements (ed. Shapiro, J.) 621–659 (Academic, New York, 1983).
Hagblom, P., Segal, E., Billgard, E. & So, M. Nature 315, 156–158 (1985).
Felsenfeld, O. Borrelia: Strains, Vectors, Human and Animal Borreliosis (Green, St Louis, Missouri, 1971).
Stoenner, H.G., Dodd, T. & Larsen, C. J. exp. Med. 156, 1297–1309 (1982).
Barbour, A.G. & Stoenner, H.G. in Genome Rearrangements (eds Herskowitz, I. & Simon, M.) (Liss, New York, 1985).
Kelly, R. Science 173, 443–444 (1971).
Barbour, A.G., Tessier, S.L. & Stoenner, H.G. J. exp. Med. 156, 1312–1316 (1982).
Barbour, A.G., & Judd, R.C. J. exp. Med. 158, 2127–2140 (1983).
Barstad, P.A., Coligan, J.E., Raum, M.G. & Barbour, A.G. J. exp. Med. 161, 1302–1314 (1985).
Meier, J.T., Simon, M.I. & Barbour, A.G. Cell 41, 403–409 (1985).
Frischauf, A.M., Lehrach, H., Poustka, A. & Murray, N. J. molec. Biol. 170, 827–842 (1983).
Schwartz, D.C. & Cantor, C.R. Cell 37, 67–75 (1984).
Zieg, J. & Simon, M.I. Proc. natn. Acad. Sci U.S.A. 77, 4196–4200 (1980).
Van de Putte, P., Cramer, S. & Giphart-Gassler, M. Nature 286, 218–222 (1980).
Golden, J.W., Robinson, S.J. & Haselkorn, R. Nature 314, 419–423 (1985).
Nasmyth, K.A. A. Rev. Genet. 16, 439–500 (1982).
Watabe, K., Shih, M.-R., Sugino, A. & Ito, J. Proc. natn. Acad. Sci. U.S.A. 79, 5245–5248 (1982).
Hiroshika, H. & Sakaguchi, K. Plasmid 7, 59–65 (1982).
Goldbach, R.W., Bollan-de Boer, J.E., Van Bruggen, E.F.J. & Borst, P. Biochim. biophys. Acta 562, 400–417 (1979).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Plasterk, R., Simon, M. & Barbour, A. Transposition of structural genes to an expression sequence on a linear plasmid causes antigenic variation in the bacterium Borrelia hermsii. Nature 318, 257–263 (1985). https://doi.org/10.1038/318257a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/318257a0
This article is cited by
-
Microbiological features distinguishing Lyme disease and relapsing fever spirochetes
Wiener klinische Wochenschrift (2018)
-
Transcriptional Expression of Six Genes Located on pBSSB1 of Salmonella enterica Serovar Typhi in Different Growth Phases and Environmental Stresses
Current Microbiology (2014)
-
Phase and antigenic variation mediated by genome modifications
Antonie van Leeuwenhoek (2008)
-
Characterisation of silent and active genes for a variable large protein of Borrelia recurrentis
BMC Infectious Diseases (2002)
-
Variable major lipoprotein is a principal TNF-inducing factor of louse-borne relapsing fever
Nature Medicine (1998)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.