Abstract
BIOLOGICALLY active polypeptides, such as bradykinin and angiotensin, have considerable importance in a variety of physiological, pharmacological and pathological reactions. We have recently reported on the extraction from normal lung tissue of a peptide fraction capable of causing gradual and prolonged peripheral vasodilatation1,2. This finding led us to pursue the search for similar vasoactive principles in extracts of other metabolically active organs. We report here on the extraction from small intestine of a highly active, hitherto unidentified vasodepressor peptide substance. The vasodilator effect of this compound, several times as prolonged as that of bradykinin, may be important as a regulator of blood flow to the digestive organs, and as a mediator in various hypotensive states.
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SAID, S., MUTT, V. Potent Peripheral and Splanchnic Vasodilator Peptide from Normal Gut. Nature 225, 863–864 (1970). https://doi.org/10.1038/225863a0
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DOI: https://doi.org/10.1038/225863a0
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