Abstract
ALTHOUGH triphenylethylene1,2 and many substituted triphenylethylenes3 are known to be oestrogenic, more complex endocrine activity has been encountered in some of its basic derivatives. A notable example is clomiphene, 1-(p-diethylaminoethoxyphenyl)-1,2-diphenyl-2-chloro-ethylene (citrate)4, which has the unexpected property of stimulating ovulation in women with ovulatory failure of certain types5,6.
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HARPER, M., WALPOLE, A. Contrasting Endocrine Activities of cis and trans Isomers in a Series of Substituted Triphenylethylenes. Nature 212, 87 (1966). https://doi.org/10.1038/212087a0
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DOI: https://doi.org/10.1038/212087a0
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