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C-Reactive Protein as a Prognostic Variable That Reflects Uncontrolled Up-Regulation of the IL-1-IL-6 Network System in Colorectal Carcinoma

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Abstract

Up-regulation of the IL-1-IL-6 network stimulates systemic expression of C-reactive protein (CRP).This cytokine network system plays a pivotal role in inducing angiogenic growth factors in in-testinalmucosa. Serum CRP level and tissue concentrations of cytokines in colorectal cancerpatients were determined and an in vitro model was employed to determine the time course ofinduction of IL-6 in Caco-2 cells. Increased serum CRP was associated with recurrent diseaseand shorter survival time. Intense surgical stress and the presence of an acute phase reactantwere independently associated with overexpression of IL-6 in the tumor. Enhanced IL-6 pro-teinexpression in Caco-2 cells induced by the initial treatment with IL-1β or lipopolysaccha-ridecould be abrogated by additional presupplementation of IL-1ra. The presence of an acutephase reactant reflects uncontrolled up-regulation of the local IL-1-IL-6 network system in thetumor, which may enhance the survival and proliferation of remnant cancer cells after tumorresection.

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Authors
  1. Chikao Miki
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  2. Naomi Konishi
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  3. Eiki Ojima
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  4. Tsuyoshi Hatada
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  5. Yasuhiro Inoue
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  6. Masato Kusunoki
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Miki, C., Konishi, N., Ojima, E. et al. C-Reactive Protein as a Prognostic Variable That Reflects Uncontrolled Up-Regulation of the IL-1-IL-6 Network System in Colorectal Carcinoma. Dig Dis Sci 49, 970–976 (2004). https://doi.org/10.1023/B:DDAS.0000034556.48527.6e

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  • DOI: https://doi.org/10.1023/B:DDAS.0000034556.48527.6e

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