Abstract
Duodenogastric reflux (DGR) in rats causesgrowth stimulation of the foregut mucosa that ispotentiated by gastric acid blockade. It was the aim ofthis study to investigate if DGR with gastric acidblockade has a higher incidence of carcinomas of theforegut than DGR alone. DGR was induced in 40Sprague-Dawley rats using a split gastroenterostomy. Acardiomyotomy was performed across the gastroesophagealjunction, inducing reflux into the esophagus. Twenty ofthese rats received omeprazole postoperatively. Afterone year 18 rats (90%) with DGR + omeprazole treatmentand 7 rats (35%) with DGR alone developed adenocarcinoma of the stomach (P < 0.05). None of the ratsdeveloped esophageal cancer, but esophageal mucosalhyperplasia was more pronounced in rats receivingomeprazole. Control rats, treated with omeprazole, did not develop carcinomas of the foregut. Inconclusion, gastric acid blockade enhanced DGR-inducedcarcinogenesis of the stomach and promotes growthstimulation of the esophageal mucosa.
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Wetscher, G.J., Hinder, R.A., Smyrk, T. et al. Gastric Acid Blockade with Omeprazole Promotes Gastric Carcinogenesis Induced by Duodenogastric Reflux. Dig Dis Sci 44, 1132–1135 (1999). https://doi.org/10.1023/A:1026615905170
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DOI: https://doi.org/10.1023/A:1026615905170