Abstract
The association between physical activity and prostate cancer was evaluated in the trial-based cohort of the Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study (n = 29,133). During up to nine years of follow-up, 317 men developed incident prostate cancer. The relationship between occupational, leisure, and combined activity and prostate cancer was assessed in multivariate Cox regression models that adjusted for intervention group, benign prostatic hyperplasia, age, smoking, and urban residence. Compared with sedentary workers, relative risks (RR) and 95 percent confidence intervals (CI) for occupational walkers, walker/lifters, and heavy laborers were 0.6 (CI = 0.4-1.0), 0.8 (CI = 0.5-1.3), and 1.2 (CI = 0.7-2.0), respectively. Among working men, leisure activity (active cf sedentary) was associated inversely with risk (RR = 0.7, CI = 0.5-0.9). This inverse association for leisure activity was observed, with the exception of heavy laborers, for all occupational acti vity levels, and was strongest among walkers compared with men sedentary at work and leisure, and to a lesser degree among walker/lifters. These results are consistent with a protective effect of physical activity on prostate cancer.
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Merrill RM, Potosky AL, Feuer EJ. Changing trends in U.S. prostate cancer incidence rates. J Natl Cancer Inst1996; 88: 1683–5.
Cancer statistics, 1996. CA Cancer J Clin1996; 65: 5–27.
Committee on Diet and Health, Food and Nutrition Board, National Research Council. Diet and Health. Washington, DC: US National Academy Press, 1989.
Sternfeld B. Cancer and the protective effect of physical activity: the epidemiologic evidence. Med Sci Sports Exerc1992; 24: 1195–209.
Wilding G. Endocrine control of prostate cancer. Cancer Surv1995; 23:434–62.
Gittes RF. Carcinoma of the prostate. N Engl J Med1991; 324: 236–45.
Giovannucci E. Epidemiologic characteristics of prostate cancer. Cancer1995; 75: 1766–77.
The ATBC Cancer Prevention Study Group. The Alphatocopherol, Beta-carotene Lung Cancer Prevention Study: design, methods, participant characteristics, and compliance. Ann Epidemiol1994; 4: 1–10.
World Health Organization. International Classification of Diseases, Ninth Revision. Geneva, Switzerland: WHO, 1977.
SAS Institute Inc. SAS/STAT Software Changes and Enhancements through Release The PHREG Procedure. Cary, NC (USA): SAS Institute Inc., 1991.
SAS Institute Inc. SAS/STAT User's Guide, Version 6, Fourth Edition. Cary, NC (USA): SAS Institute Inc., 1994.
Cox DR. Regression models and life-tables. J R Stat Soc B1972; 34: 187–220.
The ATBC Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med1994; 1029–35.
Thune I, Lund E. Physical activity and the risk of prostate and testicular cancer: a cohort study of 53,000 Norwegian men. Cancer Causes Control1994; 5: 549–56.
Hsing AW, McLaughlin JK, Zheng W, Gao Y, Blot W. Occupation, physical activity, and risk of prostate cancer in Shanghai, People's Republica of China. Cancer Causes Control1994; 5; 136–40.
Brownson RC, Chang JC, Davis JR, Smith CA. Physical activity on the job and cancer in Missouri. Am J Public Health1991; 81: 639–42.
Vena JE, Graham S, Zielezny M, Brasure J, Swanson MK. Occupational exercise and risk of cancer. Am J Clin Nutr1987; 45: 318–27.
Paffenbarger RS Jr, Hyde RT, Wing AL. Physical activity and incidence of cancer in diverse populations: a preliminary report. Am J Clin Nutr1987; 45: 312.
Dosemici M, Hayes RB, Better R, et al. Occupational physical activity, socioeconomic status, and risks of 15 cancer sites in Turkey. Cancer Causes Control1993; 4: 313–21.
Gann PH, Daviglus ML, Dyer AR, Stamler J. Heart rate and prostate cancer mortality: Results of a prospective analysis. Cancer Epidemiol Biomark Prev 4: 611–6.
Oliveria SA, Kohl HW, Trichopoulos D, Blair SN. The association between cardiorespiratory fitness and prostate cancer. Med Sci Sports Exerc1996; 28: 97–104.
Albanes D, Blair A, Taylor PR. Physical activity and risk of cancer in the NHANES I population. Am J Public Health1989; 79: 744–50.
Lee I, Paffenbarger RS Jr, Hsieh C-c. Physical activity and risk of prostate cancer among college alumni. Am J Epidemiol1992; 135: 169–79.
Yu H, Harris RE, Wynder EL. Case-control study of prostate cancer and socioeconomic factors. Prostate1988; 13: 317–25.
Whittemore AS, Kolonel LN, Wu AH, et al. Prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and Asians in the United States and Canada. J Natl Cancer Inst1995; 87: 652–61.
Le Marchand L, Kolonel L, Yoshizawa CN. Lifetime occupational physical activity an prostate cancer risk. Am J Epidemiol1991; 133: 103–11.
West DW, Slattery ML, Robison LM, French TK, Mahoney AW. Adult dietary intake and prostate cancer risk in Utah: a case-control study with special emphasis on aggressive tumors. Cancer Causes Control1991; 2: 35–94.
Paffenbarger RS Jr, Lee IM, Wing AL. The influence of physical activity on the incidence of site specific cancers in college alumni. In: Jacobs MM, ed. Exercise, Calories, Fat and Cancer. New York, NY (USA): Plenum Press, 1992.
Severson RK, Nomura AMY, Grove JS, Stemmermann GN. A prospective analysis of physical activity and cancer. Am J Epidemiol1989; 130: 522–9.
Dishman RD, Sallis KF, Orenstein DR. The determinants of physical activity and exercise. Public Health Rep1985; 100: 158–71.
Pedersen BK, Ullum H. NK cell response to physical activity: possible mechanisms of action. Med Sci Sports Exerc1994; 26: 140–6.
Woods JA, Davis JM. Exercise, monocyte/macrophage function, and cancer. Med Sci Sports Exerc1994; 26: 147–57.
Gittes RF. Carcinoma of the prostate. N Engl J Med1991; 324: 326–45.
Gann PH, Hennekens CH, Ma J, Longcope C, Stampfer MJ. Prospective study of sex hormone levels and risk of prostate cancer. J Natl Cancer Inst1996; 88: 1118–26.
Henderson BE, Ross RK, Pike MC, Casagrande JT. Endogenous hormones as a major factor in human cancer. Cancer Res1982; 42: 3232–9.
Carruba G, Pfeffer U, Fecarotta E, Coviello DA. Estradiol inhibits growth of hormone-nonresponsive PC3 human prostate cancer cells. Cancer Res1994; 54: 1190–3.
Wheeler GD, Wall SR, Belcastro AN, Cumming DC. The reduced serum testosterone and prolactin levels observed in male distance runners. JAMA1984; 252: 515–7.
Urhausen A, Kullmer T, Kindermann W. A 7-week followup study of the behavior of testosterone and cortisol during the competition period in rowers. Eur J Appl Physiol 56: 528–33.
Mantzoros CS, Georgiadis EI. Body mass and physical activity are important predictors of serum androgen concentrations in young healthy men. Epidemiology1995; 6: 432–5.
Dai WS, Kuller LH, LaPorte RE, Gutai J, Falvo-Gerard L, Caggiula A. The epidemiology of plasma testosterone levels in middle-aged men. Am J Epidemiol1981; 114: 804–16.
Shephard RJ. Physical activity and cancer. Int J Sports Med1990; 11: 413–20.
Bosland MC. The etiopathogenesis of prostatic cancer with special reference to environmental factors. Adv Cancer Res1988; 51: 1–106.
Pederson BK, Tvede N, Hansen FR, Andersen V. Modulation of natural killer cell activity in peripheral blood by physical exercise. Scand J Immunol1988, 6: 673–8.
Galbo H. The hormonal response to exercise. Proc Nutr Soc1985; 44: 257–66.
Watson RDS, Page AJF, Littler WA, Jones DH, Reid JL. Plasma noradrenaline concentrations at different rest and isometric and dynamic exercise. Clin Sci1979; 57: 545–7.
Galbo H. Hormonal and Metabolic Adaption to Exercise. New York, NY (USA): Stuttgart, 1983.
Kuoppasalmi K, Naveri H, Rehunen S, Harkonen H, Adlercreutz H. Effect of strenuous anaerobic exercise on plasma growth hormone, cortisol, luteinizing hormone, testosterone, androstenedione, estrone and estradiol. J Steroid Biochem1976; 7: 823–9.
Hetrick GA, Wilmore JH. Androgen levels and muscle hypertrophy during an eight-week weight training program for men/women. Med Science Sports1979; 11: 102.
Young RJ, Ismail AH, Bradley A, Corrigan DL. Effect of prolonged exercise on serum testosterone levels in adult men. Br J Sports Med1976; 10: 230–5.
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Hartman, T.J., Albanes, D., Rautalahti, M. et al. Physical activity and prostate cancer in the Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study (Finland). Cancer Causes Control 9, 11–18 (1998). https://doi.org/10.1023/A:1008889001519
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DOI: https://doi.org/10.1023/A:1008889001519