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The pathophysiology of extrapyramidal side-effects of neuroleptic drugs

Published online by Cambridge University Press:  09 July 2009

C. D. Marsden*
Affiliation:
University Department of Neurology, Institute of Psychiatry, and King's College Hospital Medical School, London
P. Jenner
Affiliation:
University Department of Neurology, Institute of Psychiatry, and King's College Hospital Medical School, London
*
1Address for correspondence: Professor C. D. Marsden, University Department of Neurology, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF.

Synopsis

The mechanisms responsible for the production of major extrapyramidal side-effects (parkinsonism, akathisia, acute dystonic reactions, chronic tardive dyskinesias) are reviewed in the light of the complex effects of these drugs on cerebral dopamine systems.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1980

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